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(Circulation. 2003;108:1852.)
© 2003 American Heart Association, Inc.

Clinical Investigation and Reports

Constrictive Pericarditis in 26 Patients With Histologically Normal Pericardial Thickness

Deepak R. Talreja, MD; William D. Edwards, MD; Gordon K. Danielson, MD; Hartzell V. Schaff, MD; A. Jamil Tajik, MD; Henry D. Tazelaar, MD; Jerome F. Breen, MD; Jae K. Oh, MD

From the Division of Cardiovascular Diseases and Internal Medicine (D.R.T., A.J.T., J.K.O.), the Division of Anatomic Pathology (W.D.E., H.D.T.), the Division of Cardiovascular Surgery (G.K.D., H.V.S.), and the Department of Radiology (J.F.B.), Mayo Clinic, Rochester, Minn.

Reprint requests to Jae K. Oh, MD, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

Received April 15, 2003; revision received July 7, 2003; accepted July 8, 2003.

Background— Traditionally, increased pericardial thickness has been considered an essential diagnostic feature of constrictive pericarditis. Although constriction with a normal-thickness pericardium has been demonstrated clinically by noninvasive imaging, the details of clinicopathological correlates have not been described.

Methods and Results— A total of 143 patients with proven constriction underwent pericardiectomy at Mayo Clinic between 1993 and 1999. Their baseline characteristics, operative data, and pathological specimens were reviewed retrospectively. The pericardium was of normal thickness (2 mm) in 26 patients (18%; group 1) and was thickened (>2 mm) in 117 (82%; group 2). The most common causes of constriction in group 1 included previous cardiac surgery, chest irradiation, previous infarction, and idiopathic disease. There was little difference in symptoms and findings on physical examination between the 2 groups. Microscopically, no patient had an entirely normal pericardium. Histopathological abnormalities in group 1 were mild and focal, including fibrosis, inflammation, calcification, fibrin deposition, and focal noncaseating granulomas. Pericardiectomy was equally effective in relieving symptoms regardless of the presence or absence of increased thickness.

Conclusions— Pericardial thickness was not increased in 18% of patients with surgically proven constrictive pericarditis, although the histopathological appearance was focally abnormal in all cases. When clinical, echocardiographic, or invasive hemodynamic features indicate constriction in patients with heart failure, pericardiectomy should not be denied on the basis of normal thickness as demonstrated by noninvasive imaging.

Key Words: pathology • pericarditis • pericardium

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