This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rosen, M. R. Articles by Marom, S. Search for Related Content PubMed PubMed Citation Articles by Rosen, M. R. Articles by Marom, S. Related Collections Health policy and outcome research Cardiac development Arrythmias-basic studies

(Circulation. 2003;108:1784.)
© 2003 American Heart Association, Inc.

Review: Current Perspective

Cardiac Memory and Cortical Memory

Do Learning Patterns in Neural Networks Impact on Cardiac Arrhythmias?

Michael R. Rosen, MD; Ofer Binah, PhD; Shimon Marom, PhD

From the Departments of Pharmacology and Pediatrics, Center for Molecular Therapeutics, New York, NY (M.R.R.), and Technion-Israel Institute of Technology, Haifa, Israel (O.B., S.M.).

Correspondence to Michael R. Rosen, MD, Gustavus A. Pfeiffer Professor of Pharmacology, Professor of Pediatrics, College of Physicians and Surgeons of Columbia University, Department of Pharmacology, 630 W 168 St, PH 7West-321, New York, NY 10032. E-mail mrr1{at}columbia.edu

Received May 5, 2003; revision received June 17, 2003; accepted June 17, 2003.

Memory is a property of diverse biological systems, including brain and heart. Studies in cortical neuronal networks have identified an increased sensitivity to infrequent (rare) stimulation patterns that can result in their achieving dominance over network firing. This adaptive behavior is applied to the heart in an attempt to explain the ability of pulmonary venous and other ectopic foci to achieve dominance over cardiac rhythm. Developmental changes in determinants of cardiac rhythm are explored as possible determinants of the range of rhythms expressed by the heart. By understanding the mechanisms for these behavior patterns, we may obtain new means for manipulating memory to return dysrhythmic hearts to normal sinus rhythm.

Key Words: tachyarrhythmia • nervous system • atrium • heart rate

This article has been cited by other articles:

				N. Ozgen, W. Dun, E. A. Sosunov, E. P. Anyukhovsky, M. Hirose, H. S. Duffy, P. A. Boyden, and M. R. Rosen Early electrical remodeling in rabbit pulmonary vein results from trafficking of intracellular SK2 channels to membrane sites Cardiovasc Res, September 1, 2007; 75(4): 758 - 769. [Abstract] [Full Text] [PDF]

				A. M. Yue, T. R. Betts, P. R. Roberts, and J. M. Morgan Global Dynamic Coupling of Activation and Repolarization in the Human Ventricle Circulation, October 25, 2005; 112(17): 2592 - 2601. [Abstract] [Full Text] [PDF]

				E. A. Sosunov, E. P. Anyukhovsky, D. Hefer, T. S. Rosen, P. Danilo Jr., M. J. Janse, and M. R. Rosen Region-specific, pacing-induced changes in repolarization in rabbit atrium: An example of sensitivity to the rare Cardiovasc Res, August 1, 2005; 67(2): 274 - 282. [Abstract] [Full Text] [PDF]

				F. W. Prinzen, K. Vernooy, and R. N. Cornelussen Cardiac Memory and Cortical Memory Circulation, May 25, 2004; 109(20): e226 - e226. [Full Text] [PDF]