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(Circulation. 2003;108:1295.)
© 2003 American Heart Association, Inc.

Brief Rapid Communications

Impact of Preinterventional Arterial Remodeling on Neointimal Hyperplasia After Implantation of (Non–Polymer-Encapsulated) Paclitaxel-Coated Stents

A Serial Volumetric Intravascular Ultrasound Analysis From the ASian Paclitaxel-Eluting Stent Clinical Trial (ASPECT)

Gary S. Mintz, MD; Adrienne Tinana, BS; Myeong-Ki Hong, MD; Cheol Whan Lee, MD; Jae-Joong Kim, MD; Neal E. Fearnot, PhD; Seong-Wook Park, MD; Seung-Jung Park, MD; Neil J. Weissman, MD

From the Department of Medicine (M.-K.H., C.W.L., J.-J.K., S.-W.P., S.-J.P.), University of Ulsan College of Medicine, Seoul, Korea; Cardiovascular Research Foundation (G.S.M.), New York, NY; Washington Hospital Center (A.T., N.J.W.), Washington, DC; and MED Institute, Inc (N.E.F.), West Lafayette, Ind.

Correspondence to Neil J. Weissman, MD, Washington Hospital Center, 110 Irving St, Suite 4B-1, Washington, DC 20010. E-mail Neil.J.Weissman{at}medstar.net

Received March 20, 2003; de novo received July 10, 2003; accepted July 28, 2003.

Background— This study used serial volumetric intravascular ultrasound (IVUS) to evaluate the effect of preinterventional arterial remodeling on in-stent intimal hyperplasia (IH) after implantation of non–polymer-encapsulated paclitaxel-coated stents.

Methods and Results— Patients were randomized to placebo or one of two doses of paclitaxel (low dose, 1.28 µg/mm²; high dose, 3.10 µg/mm²). Complete preinterventional, post–stent implantation, and follow-up IVUS were available in 18 low-dose and 21 high-dose patients. IH volumes were similar in low-dose and high-dose patients: 17.6±15.1 mm³ in low-dose patients and 13.1±13.3 mm³ in high-dose patients (P=0.3). Therefore, IVUS findings in low- and high-dose patients were combined. Preinterventional remodeling was assessed by comparing lesion site to proximal and distal reference arterial area: positive remodeling (lesion>proximal reference, n=13), intermediate remodeling (distal reference<lesion<proximal reference, n=13), and negative remodeling (lesion<distal reference, n=13). During follow-up, there was a decrease in lumen volume in positive remodeling lesions (from 106±30 to 90±27 mm³; P=0.0067) and in intermediate remodeling lesions (from 97±28 to 76±31 mm³; P=0.0004), but not in negative remodeling lesions (99±27 versus 92±32 mm³; P=0.15). The follow-up IH volume was lower in negative remodeling lesions (5±7 mm³) compared with positive remodeling (20±14 mm³; P=0.0051) and intermediate remodeling lesions (20±15 mm³; P=0.0043); however, IH volume was virtually identical in positive and intermediate remodeling lesions. Multivariate linear regression analysis determined that remodeling and inflation pressure were independent predictors of IH volume; variables tested in the model included diabetes, acute coronary syndromes, dose, remodeling, and preinterventional plaque burden.

Conclusions— Preinterventional arterial remodeling, especially negative remodeling, influences neointimal hyperplasia suppression after implantation of non–polymer-encapsulated paclitaxel-coated stents.

Key Words: stents • remodeling • ultrasonics • hyperplasia • paclitaxel

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