Circulation. 2003;107:1278-1283
Published online before print February 24, 2003, doi: 10.1161/01.CIR.0000054164.99881.00
Published online before print February 24, 2003, doi: 10.1161/01.CIR.0000054164.99881.00
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2003;107:1278.)
© 2003 American Heart Association, Inc.
Clinical Investigation and Reports |
Changes in Brain Natriuretic Peptide and Norepinephrine Over Time and Mortality and Morbidity in the Valsartan Heart Failure Trial (Val-HeFT)
From the VA Medical Center and University of Minnesota (I.S.A.), Minneapolis, Minn; Department of Biostatistics (L.D.F.), University of Washington, Seattle, Wash; Novartis Pharmaceuticals Corporation (Y.-T.C., R.D.G.), East Hanover, NJ; Istituto "Mario Negri" (R.L., S.M., G.T.), Milan, Italy; ANMCO Research Center (A.P.M.), Florence, Italy; and University of Minnesota (J.N.C.), Minneapolis, Minn.
Correspondence to Inder S. Anand, MD, Director of Heart Failure Program, Veterans Administration Medical Center, One Veterans Drive 111-C, Minneapolis, MN 55417. E-mail anand001{at}tc.umn.edu
Background— Neurohormones are considered markers of heart failure progression. We examined whether changes in brain natriuretic peptide (BNP) and norepinephrine (NE) over time are associated with corresponding changes in mortality and morbidity in the Valsartan Heart Failure Trial.
Methods and Results— Plasma BNP and NE were measured before randomization and during follow-up in 
4300 patients in the Valsartan Heart Failure Trial. The relation between baseline BNP and NE and all-cause mortality and first morbid event (M&M) was analyzed in subgroups, with values above and below the median, and by quartiles. The change and percent change from baseline to 4 and 12 months in BNP and NE were also analyzed by quartiles for subsequent M&M. Risk ratios for M&M were calculated using a Cox proportional hazard model. Risk ratio of M&M for patients with baseline BNP or NE above the median was significantly higher than that for patients with values below the median. Baseline BNP and NE in quartiles also showed a quartile-dependent increase in M&M. BNP had a stronger association with M&M than NE. Patients with the greatest percent decrease in BNP and NE from baseline to 4 and 12 months had the lowest whereas patients with greatest percent increase in BNP and NE had the highest M&M.
Conclusions— Not only are plasma BNP and NE important predictors of heart failure M&M, but changes in these neurohormones over time are associated with corresponding changes in M&M. These data further reinforce their role as significant surrogate markers in HF and underscore the importance of including their measurement in HF trials.
Key Words: heart failure • trials, clinical • natriuretic peptides • norepinephrine
Related Article:
Circulation 2003 107: 1231-1233.
This article has been cited by other articles:
 |
|
 |
|
  E. Braunwald Biomarkers in Heart Failure N. Engl. J. Med., May 15, 2008; 358(20): 2148 - 2159. [Full Text] [PDF]
|
|
|
|
 |
|
 J T Parissis, M Nikolaou, D Farmakis, V Bistola, I A Paraskevaidis, S Adamopoulos, G Filippatos, and D T Kremastinos Clinical and prognostic implications of self-rating depression scales and plasma B-type natriuretic peptide in hospitalised patients with chronic heart failure Heart, May 1, 2008; 94(5): 585 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Pascual-Figal, M. Domingo, T. Casas, I. Gich, J. Ordonez-Llanos, P. Martinez, J. Cinca, M. Valdes, J. L. Januzzi, and A. Bayes-Genis Usefulness of clinical and NT-proBNP monitoring for prognostic guidance in destabilized heart failure outpatients Eur. Heart J., April 2, 2008; 29(8): 1011 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Moller, C. Torp-Pedersen, and L. V. Kober Is heart failure the critical warning sign for death following myocardial infarction? Eur. Heart J., April 1, 2008; 29(7): 833 - 834. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Weber, O. Bazzino, J. L. Navarro Estrada, J. J. Fuselli, F. Botto, D. Perez de Arenaza, H. Mollmann, H. N. Nef, A. Elsasser, and C. W. Hamm N-Terminal B-Type Natriuretic Peptide Assessment Provides Incremental Prognostic Information in Patients With Acute Coronary Syndromes and Normal Troponin T Values Upon Admission J. Am. Coll. Cardiol., March 25, 2008; 51(12): 1188 - 1195. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. B. Daniels and A. S. Maisel Natriuretic Peptides J. Am. Coll. Cardiol., December 18, 2007; 50(25): 2357 - 2368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. von Haehling, E. A. Jankowska, N. G. Morgenthaler, C. Vassanelli, L. Zanolla, P. Rozentryt, G. S. Filippatos, W. Doehner, F. Koehler, J. Papassotiriou, et al. Comparison of Midregional Pro-Atrial Natriuretic Peptide With N-Terminal Pro-B-Type Natriuretic Peptide in Predicting Survival in Patients With Chronic Heart Failure J. Am. Coll. Cardiol., November 13, 2007; 50(20): 1973 - 1980. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maisel Biomarkers in Heart Failure: Does Prognostic Utility Translate to Clinical Futility? J. Am. Coll. Cardiol., September 11, 2007; 50(11): 1061 - 1063. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Otte, J. McCaffery, S. Ali, and M. A. Whooley Association of a Serotonin Transporter Polymorphism (5-HTTLPR) With Depression, Perceived Stress, and Norepinephrine in Patients With Coronary Disease: The Heart and Soul Study Am J Psychiatry, September 1, 2007; 164(9): 1379 - 1384. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Karabinos, E. Karvouni, N. Chiotinis, A. Papadopoulos, P. Simeonidis, O. Tsolas, and D. Katritsis Acute changes in N-terminal pro-brain natriuretic peptide induced by dobutamine stress echocardiography Eur J Echocardiogr, August 1, 2007; 8(4): 265 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.H. Wilson Tang, G. S. Francis, D. A. Morrow, L. K. Newby, C. P. Cannon, R. L. Jesse, A. B. Storrow, R. H. Christenson, COMMITTEE MEMBERS, R. H. Christenson, et al. National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines: Clinical Utilization of Cardiac Biomarker Testing in Heart Failure Circulation, July 31, 2007; 116(5): e99 - e109. [Full Text] [PDF]
|
|
|
|
|
|
W. L. Miller, K. A. Hartman, M. F. Burritt, D. E. Grill, R. J. Rodeheffer, J. C. Burnett Jr, and A. S. Jaffe Serial Biomarker Measurements in Ambulatory Patients With Chronic Heart Failure: The Importance of Change Over Time Circulation, July 17, 2007; 116(3): 249 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. El-Khuffash and E. J Molloy Are B-type natriuretic peptide (BNP) and N-terminal-pro-BNP useful in neonates? Arch. Dis. Child. Fetal Neonatal Ed., July 1, 2007; 92(4): F320 - F324. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. C. Fonarow, W. F. Peacock, C. O. Phillips, M. M. Givertz, M. Lopatin, and for the ADHERE Scientific Advisory Committee and I Admission B-Type Natriuretic Peptide Levels and In-Hospital Mortality in Acute Decompensated Heart Failure J. Am. Coll. Cardiol., May 15, 2007; 49(19): 1943 - 1950. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Sartipy, A. Albage, P. T. Larsson, P. Insulander, and D. Lindblom Changes in B-type natriuretic peptides after surgical ventricular restoration Eur. J. Cardiothorac. Surg., May 1, 2007; 31(5): 922 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Felker, J. W. Petersen, and D. B. Mark Natriuretic peptides in the diagnosis and management of heart failure. Can. Med. Assoc. J., September 12, 2006; 175(6): 611 - 617. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Price, A. K. Thomas, M. Grenier, B. W. Eidem, E. O. Smith, S. W. Denfield, J. A. Towbin, and W. J. Dreyer B-Type Natriuretic Peptide Predicts Adverse Cardiovascular Events in Pediatric Outpatients With Chronic Left Ventricular Systolic Dysfunction Circulation, September 5, 2006; 114(10): 1063 - 1069. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. H. Chen and J. C. Burnett Jr Clinical application of the natriuretic peptides in heart failure Eur. Heart J. Suppl., September 1, 2006; 8(suppl_E): E18 - E25. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. De Luca, W. S. Colucci, M. S. Nieminen, B. M. Massie, and M. Gheorghiade Evidence-based use of levosimendan in different clinical settings Eur. Heart J., August 2, 2006; 27(16): 1908 - 1920. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Klein, C. Lissel, A.-C. Fuchs, A. Gardiwal, H. Oswald, M. deSousa, A. M. Pichlmaier, R. Lichtinghagen, H. Geerlings, P. Lippolt, et al. Predictors of VT/VF-occurrence in ICD patients: results from the PROFIT-Study. Europace, August 1, 2006; 8(8): 618 - 624. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Rienstra, I. C. Van Gelder, M. P. Van den Berg, F. Boomsma, and D. J. Van Veldhuisen Natriuretic peptides in patients with atrial fibrillation and advanced chronic heart failure: determinants and prognostic value of (NT-)ANP and (NT-pro)BNP Europace, July 1, 2006; 8(7): 482 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hammerer-Lercher, R. Geiger, J. Mair, C. Url, G. Tulzer, E. Lechner, B. Puschendorf, and R. Sommer Utility of N-Terminal Pro-B-Type Natriuretic Peptide to Differentiate Cardiac Diseases from Noncardiac Diseases in Young Pediatric Patients Clin. Chem., July 1, 2006; 52(7): 1415 - 1419. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Weber and C. Hamm Role of B-type natriuretic peptide (BNP) and NT-proBNP in clinical routine. Heart, June 1, 2006; 92(6): 843 - 849. [Full Text] [PDF]
|
|
|
|
|
|
M. von Eynatten, A. Hamann, D. Twardella, P. P. Nawroth, H. Brenner, and D. Rothenbacher Relationship of Adiponectin with Markers of Systemic Inflammation, Atherogenic Dyslipidemia, and Heart Failure in Patients with Coronary Heart Disease Clin. Chem., May 1, 2006; 52(5): 853 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. G. Tsouli, E. N. Liberopoulos, D. N. Kiortsis, D. P. Mikhailidis, and M. S. Elisaf Combined Treatment With Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers: A Review of the Current Evidence Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2006; 11(1): 1 - 15. [Abstract] [PDF]
|
|
|
|
|
|
Y. Iwanaga, I. Nishi, S. Furuichi, T. Noguchi, K. Sase, Y. Kihara, Y. Goto, and H. Nonogi B-Type Natriuretic Peptide Strongly Reflects Diastolic Wall Stress in Patients With Chronic Heart Failure: Comparison Between Systolic and Diastolic Heart Failure J. Am. Coll. Cardiol., February 21, 2006; 47(4): 742 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Davis, A. M. Richards, M. G. Nicholls, T. G. Yandle, C. M. Frampton, and R. W. Troughton Introduction of Metoprolol Increases Plasma B-Type Cardiac Natriuretic Peptides in Mild, Stable Heart Failure Circulation, February 21, 2006; 113(7): 977 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Januzzi Jr, R. Sakhuja, M. O'Donoghue, A. L. Baggish, S. Anwaruddin, C. U. Chae, R. Cameron, D. G. Krauser, R. Tung, C. A. Camargo Jr, et al. Utility of amino-terminal pro-brain natriuretic Peptide testing for prediction of 1-year mortality in patients with dyspnea treated in the emergency department. Arch Intern Med, February 13, 2006; 166(3): 315 - 320. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G A Wright and A D Struthers Natriuretic peptides as a prognostic marker and therapeutic target in heart failure Heart, February 1, 2006; 92(2): 149 - 151. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. B. Horwich, M. A. Hamilton, and G. C. Fonarow B-Type Natriuretic Peptide Levels in Obese Patients With Advanced Heart Failure J. Am. Coll. Cardiol., January 3, 2006; 47(1): 85 - 90. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Richards, M. G. Nicholls, E. A. Espiner, J. G. Lainchbury, R. W. Troughton, J. Elliott, C. M. Frampton, I. G. Crozier, T. G. Yandle, R. Doughty, et al. Comparison of B-Type Natriuretic Peptides for Assessment of Cardiac Function and Prognosis in Stable Ischemic Heart Disease J. Am. Coll. Cardiol., January 3, 2006; 47(1): 52 - 60. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Otte, T. C. Neylan, S. S. Pipkin, W. S. Browner, and M. A. Whooley Depressive Symptoms and 24-Hour Urinary Norepinephrine Excretion Levels in Patients With Coronary Disease: Findings From the Heart and Soul Study Am J Psychiatry, November 1, 2005; 162(11): 2139 - 2145. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Norozi, R. Buchhorn, C. Kaiser, G. Hess, R. W. Grunewald, L. Binder, and A. Wessel Plasma N-Terminal Pro-Brain Natriuretic Peptide as a Marker of Right Ventricular Dysfunction in Patients With Tetralogy of Fallot After Surgical Repair Chest, October 1, 2005; 128(4): 2563 - 2570. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Kistorp, J. Faber, S. Galatius, F. Gustafsson, J. Frystyk, A. Flyvbjerg, and P. Hildebrandt Plasma Adiponectin, Body Mass Index, and Mortality in Patients With Chronic Heart Failure Circulation, September 20, 2005; 112(12): 1756 - 1762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. S. Anand, R. Latini, V. G. Florea, M. A. Kuskowski, T. Rector, S. Masson, S. Signorini, P. Mocarelli, A. Hester, R. Glazer, et al. C-Reactive Protein in Heart Failure: Prognostic Value and the Effect of Valsartan Circulation, September 6, 2005; 112(10): 1428 - 1434. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O Gosling, M Martin, E Clarke, A Smith, E Coombes, and M Dawes Angiotensin II, but not aldosterone and renin, correlates positively with increased concentrations of N-terminal pro-brain natriuretic peptide in patients with chronic heart failure Heart, September 1, 2005; 91(9): 1223 - 1224. [Full Text] [PDF]
|
|
|
|
|
|
I. S. Anand, M. A. Kuskowski, T. S. Rector, V. G. Florea, R. D. Glazer, A. Hester, Y. T. Chiang, N. Aknay, A. P. Maggioni, C. Opasich, et al. Anemia and Change in Hemoglobin Over Time Related to Mortality and Morbidity in Patients With Chronic Heart Failure: Results From Val-HeFT Circulation, August 23, 2005; 112(8): 1121 - 1127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. W. Gold, M.-L. Wong, D. S. Goldstein, H. K. Gold, D. S. Ronsaville, M. Esler, S. Alesci, A. Masood, J. Licinio, T. D. Geracioti Jr., et al. Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia PNAS, June 7, 2005; 102(23): 8303 - 8308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Petersson, P. Friberg, G. Eisenhofer, G. Lambert, and B. Rundqvist Long-term outcome in relation to renal sympathetic activity in patients with chronic heart failure Eur. Heart J., May 1, 2005; 26(9): 906 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.M. Makikallio, T.H. Makikallio, J.T. Korpelainen, O. Vuolteenaho, J.M. Tapanainen, K. Ylitalo, K.A. Sotaniemi, H.V. Huikuri, and V.V. Myllyla Natriuretic Peptides and Mortality After Stroke Stroke, May 1, 2005; 36(5): 1016 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A Doust, E. Pietrzak, A. Dobson, and P. Glasziou How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: systematic review BMJ, March 19, 2005; 330(7492): 625. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. L. Miller, K. A. Hartman, M. F. Burritt, D. D. Borgeson, J. C. Burnett Jr, and A. S. Jaffe Biomarker Responses during and after Treatment with Nesiritide Infusion in Patients with Decompensated Chronic Heart Failure Clin. Chem., March 1, 2005; 51(3): 569 - 577. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Bassan, A. Potsch, A. Maisel, B. Tura, H. Villacorta, M. V. Nogueira, A. Campos, R. Gamarski, A. C. Masetto, and M. A. Moutinho B-type natriuretic peptide: a novel early blood marker of acute myocardial infarction in patients with chest pain and no ST-segment elevation Eur. Heart J., February 1, 2005; 26(3): 234 - 240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. M. Conraads, P. Beckers, J. Vaes, M. Martin, V. Van Hoof, C. De Maeyer, N. Possemiers, F. L. Wuyts, and C. J. Vrints Combined endurance/resistance training reduces NT-proBNP levels in patients with chronic heart failure Eur. Heart J., October 2, 2004; 25(20): 1797 - 1805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.R. Bristow, H. Krause-Steinrauf, R. Nuzzo, C.-S. Liang, J. Lindenfeld, B.D. Lowes, B. Hattler, W.T. Abraham, L. Olson, S. Krueger, et al. Effect of Baseline or Changes in Adrenergic Activity on Clinical Outcomes in the {beta}-Blocker Evaluation of Survival Trial Circulation, September 14, 2004; 110(11): 1437 - 1442. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Suzuki, M. Yoshimura, M. Nakayama, Y. Mizuno, E. Harada, T. Ito, S. Nakamura, K. Abe, M. Yamamuro, T. Sakamoto, et al. Plasma Level of B-Type Natriuretic Peptide as a Prognostic Marker After Acute Myocardial Infarction: A Long-Term Follow-Up Analysis Circulation, September 14, 2004; 110(11): 1387 - 1391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Harrison, V. Bhalla, N. Gardetto, and A. S. Maisel Evolving Use of B-Type Natriuretic Peptide in Clinical Practice Clin. Chem., September 1, 2004; 50(9): 1714 - 1715. [Full Text] [PDF]
|
|
|
|
 |
|
 S. Schenk, P. M. McCarthy, R. C. Starling, K. J. Hoercher, M. D. Hail, Y. Ootaki, G. S. Francis, K. Doi, J. B. Young, and K. Fukamachi Neurohormonal response to left ventricular reconstruction surgery in ischemic cardiomyopathy J. Thorac. Cardiovasc. Surg., July 1, 2004; 128(1): 38 - 43. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N. Cohn Clinical Research: Whose Agenda Is It? Circulation, May 18, 2004; 109(19): 2256 - 2262. [Full Text] [PDF]
|
|
|
|
|
|
A. Yndestad, T. Ueland, E. Oie, G. Florholmen, B. Halvorsen, H. Attramadal, S. Simonsen, S. S. Froland, L. Gullestad, G. Christensen, et al. Elevated Levels of Activin A in Heart Failure: Potential Role in Myocardial Remodeling Circulation, March 23, 2004; 109(11): 1379 - 1385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Maron, V. N. Tholakanahalli, A. G. Zenovich, S. A. Casey, D. Duprez, D. M. Aeppli, and J. N. Cohn Usefulness of B-Type Natriuretic Peptide Assay in the Assessment of Symptomatic State in Hypertrophic Cardiomyopathy Circulation, March 2, 2004; 109(8): 984 - 989. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Troughton, D. L. Prior, J. J. Pereira, M. Martin, A. Fogarty, A. Morehead, T. G. Yandle, A. M. Richards, R. C. Starling, J. B. Young, et al. Plasma B-type natriuretic peptide levels in systolic heart failure: importance of left ventricular diastolic function and right ventricular systolic function J. Am. Coll. Cardiol., February 4, 2004; 43(3): 416 - 422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Givertz and E. Braunwald Neurohormones in heart failure: predicting outcomes, optimizing care Eur. Heart J., February 2, 2004; 25(4): 281 - 282. [Full Text] [PDF]
|
|
|
|
|
|
S. de Denus, C. Pharand, and D. R. Williamson Brain Natriuretic Peptide in the Management of Heart Failure: The Versatile Neurohormone Chest, February 1, 2004; 125(2): 652 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|