Circulation. 2003;107:671-674
Published online before print January 27, 2003, doi: 10.1161/01.CIR.0000055188.83694.B3
Published online before print January 27, 2003, doi: 10.1161/01.CIR.0000055188.83694.B3
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2003;107:671.)
© 2003 American Heart Association, Inc.
Brief Rapid Communications |
Reciprocal Association of C-Reactive Protein With Adiponectin in Blood Stream and Adipose Tissue
From the Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Correspondence to Noriyuki Ouchi, MD, PhD, Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, 2-2, Yamada-oka, Suita, Osaka, 565-0871, Japan. E-mail ouchi{at}imed2.med.osaka-u.ac.jp
Background— High-sensitive C-reactive protein (hs-CRP) is a well-known risk factor for coronary artery disease (CAD). Recently, we have demonstrated that adiponectin served as an antiatherogenic plasma protein which was secreted specifically from adipocytes. The present study investigated the association between adiponectin and CRP in the blood stream and adipose tissue.
Methods and Results— We studied a total of 101 male patients, 71 of whom had angiographically documented coronary atherosclerosis. As a control group, 30 patients with normal coronary angiogram were included. The plasma hs-CRP levels were negatively correlated with the plasma adiponectin levels (r=-0.29, P<0.01). The plasma adiponectin concentrations were significantly lower and the hs-CRP levels were significantly higher in the CAD patients compared with control subjects. The mRNA levels of CRP and adiponectin were analyzed by quantitative real-time polymerase chain reaction method. We found that the CRP mRNA was expressed in human adipose tissue. A significant inverse correlation was observed between the CRP and adiponectin mRNA levels in human adipose tissue (r=-0.89, P<0.01). In addition, the CRP mRNA level of white adipose tissue in adiponectin deficient mice was higher than that of wild-type mice.
Conclusions— The reciprocal association of adiponectin and CRP levels in both human plasma and adipose tissue might participate in the development of atherosclerosis.
Key Words: coronary disease • risk factors • inflammation • proteins
This article has been cited by other articles:
 |
|
 |
|
  R. C.M. van Kruijsdijk, E. van der Wall, and F. L.J. Visseren Obesity and Cancer: The Role of Dysfunctional Adipose Tissue Cancer Epidemiol. Biomarkers Prev., October 1, 2009; 18(10): 2569 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Broch, M. T. Auguet, R. Ramirez, M. Olona, C. Aguilar, A. Megia, M. J. Alcaide, R. Pastor, S. Martinez, E. Caubet, et al. Parallel downregulation of retinol-binding protein-4 and adiponectin expression in subcutaneous adipose tissue of non-morbidly obese subjects Eur. J. Endocrinol., July 1, 2009; 161(1): 87 - 94. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bumrungpert, R. W. Kalpravidh, C. Chitchumroonchokchai, C.-C. Chuang, T. West, A. Kennedy, and M. McIntosh Xanthones from Mangosteen Prevent Lipopolysaccharide-Mediated Inflammation and Insulin Resistance in Primary Cultures of Human Adipocytes J. Nutr., June 1, 2009; 139(6): 1185 - 1191. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Mahabadi, J. M. Massaro, G. A. Rosito, D. Levy, J. M. Murabito, P. A. Wolf, C. J. O'Donnell, C. S. Fox, and U. Hoffmann Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: the Framingham Heart Study Eur. Heart J., April 1, 2009; 30(7): 850 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Frankel, R. S. Vasan, R. B. D'Agostino Sr, E. J. Benjamin, D. Levy, T. J. Wang, and J. B. Meigs Resistin, Adiponectin, and Risk of Heart Failure: The Framingham Offspring Study J. Am. Coll. Cardiol., March 3, 2009; 53(9): 754 - 762. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Devaraj, U. Singh, and I. Jialal The Evolving Role of C-Reactive Protein in Atherothrombosis Clin. Chem., February 1, 2009; 55(2): 229 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Aprahamian, R. G. Bonegio, C. Richez, K. Yasuda, L.-K. Chiang, K. Sato, K. Walsh, and I. R. Rifkin The Peroxisome Proliferator-Activated Receptor {gamma} Agonist Rosiglitazone Ameliorates Murine Lupus by Induction of Adiponectin J. Immunol., January 1, 2009; 182(1): 340 - 346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F M E Franssen, D E O'Donnell, G H Goossens, E E Blaak, and A M W J Schols Obesity and the lung: 5 {middle dot} Obesity and COPD Thorax, December 1, 2008; 63(12): 1110 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Puglisi and M. L. Fernandez Modulation of C-Reactive Protein, Tumor Necrosis Factor-{alpha}, and Adiponectin by Diet, Exercise, and Weight Loss J. Nutr., December 1, 2008; 138(12): 2293 - 2296. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bakhai Adipokines--targeting a root cause of cardiometabolic risk QJM, October 1, 2008; 101(10): 767 - 776. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Teoh, A. Quan, K. W. A. Bang, G. Wang, F. Lovren, V. Vu, J. J. Haitsma, P. E. Szmitko, M. Al-Omran, C.-H. Wang, et al. Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality Am J Physiol Endocrinol Metab, September 1, 2008; 295(3): E658 - E664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. K.-T. Li, B. C.-H. Kwan, C. C. Szeto, and G. T.-C. Ko Metabolic syndrome in peritoneal dialysis patients NDT Plus, August 1, 2008; 1(4): 206 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Karmazyn, D. M. Purdham, V. Rajapurohitam, and A. Zeidan Signalling mechanisms underlying the metabolic and other effects of adipokines on the heart Cardiovasc Res, July 15, 2008; 79(2): 279 - 286. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Ouchi and K. Walsh A Novel Role for Adiponectin in the Regulation of Inflammation Arterioscler Thromb Vasc Biol, July 1, 2008; 28(7): 1219 - 1221. [Full Text] [PDF]
|
|
|
|
|
|
S. Devaraj, N. Torok, M. R. Dasu, D. Samols, and I. Jialal Adiponectin Decreases C-Reactive Protein Synthesis and Secretion From Endothelial Cells: Evidence for an Adipose Tissue-Vascular Loop Arterioscler Thromb Vasc Biol, July 1, 2008; 28(7): 1368 - 1374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Tabara, H. Osawa, R. Kawamoto, R. Tachibana-Iimori, M. Yamamoto, J. Nakura, T. Miki, H. Makino, and K. Kohara Reduced High-Molecular-Weight Adiponectin and Elevated High-Sensitivity C-Reactive Protein Are Synergistic Risk Factors for Metabolic Syndrome in a Large-Scale Middle-Aged to Elderly Population: the Shimanami Health Promoting Program Study J. Clin. Endocrinol. Metab., March 1, 2008; 93(3): 715 - 722. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Matsumoto, S. Ishikawa, and E. Kajii Association of Adiponectin With Cerebrovascular Disease: A Nested Case-Control Study Stroke, February 1, 2008; 39(2): 323 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Okamoto, E. J. Folco, M. Minami, A.K. Wara, M. W. Feinberg, G. K. Sukhova, R. A. Colvin, S. Kihara, T. Funahashi, A. D. Luster, et al. Adiponectin Inhibits the Production of CXC Receptor 3 Chemokine Ligands in Macrophages and Reduces T-Lymphocyte Recruitment in Atherogenesis Circ. Res., February 1, 2008; 102(2): 218 - 225. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. H Rokling-Andersen, J. E Reseland, M. B Veierod, S. A Anderssen, D. R Jacobs Jr, P. Urdal, J.-O. Jansson, and C. A Drevon Effects of long-term exercise and diet intervention on plasma adipokine concentrations Am. J. Clinical Nutrition, November 1, 2007; 86(5): 1293 - 1301. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Gustafson, A. Hammarstedt, C. X. Andersson, and U. Smith Inflamed Adipose Tissue: A Culprit Underlying the Metabolic Syndrome and Atherosclerosis Arterioscler Thromb Vasc Biol, November 1, 2007; 27(11): 2276 - 2283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Velasquez-Mieyer, C. P. Neira, R. Nieto, and P. A. Cowan Review: Obesity and cardiometabolic syndrome in children Therapeutic Advances in Cardiovascular Disease, October 1, 2007; 1(1): 61 - 81. [Abstract] [PDF]
|
|
|
|
|
|
B. Memoli, A. Procino, P. Calabro, P. Esposito, G. Grandaliano, G. Pertosa, M. D. Prete, M. Andreucci, S. D. Lillo, G. Ferulano, et al. Inflammation may modulate IL-6 and C-reactive protein gene expression in the adipose tissue: the role of IL-6 cell membrane receptor Am J Physiol Endocrinol Metab, October 1, 2007; 293(4): E1030 - E1035. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Maahs, L. G. Ogden, J. K. Snell-Bergeon, G. L. Kinney, R. P. Wadwa, J. E. Hokanson, D. Dabelea, A. Kretowski, R. H. Eckel, and M. Rewers Determinants of Serum Adiponectin in Persons with and without Type 1 Diabetes Am. J. Epidemiol., September 15, 2007; 166(6): 731 - 740. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C.H. Kwan, M. A. Murtaugh, and S. Beddhu Associations of Body Size with Metabolic Syndrome and Mortality in Moderate Chronic Kidney Disease Clin. J. Am. Soc. Nephrol., September 1, 2007; 2(5): 992 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Y. Han, S. Subramanian, C. K. Chan, M. Omer, T. Chiba, T. N. Wight, and A. Chait Adipocyte-Derived Serum Amyloid A3 and Hyaluronan Play a Role in Monocyte Recruitment and Adhesion Diabetes, September 1, 2007; 56(9): 2260 - 2273. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Yuan, X. Chen, Q. Ma, J. Qiao, R. Li, X. Li, S. Li, J. Tang, L. Zhou, H. Song, et al. C-reactive protein inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes J. Endocrinol., August 1, 2007; 194(2): 275 - 281. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. G. Hanley, D. Bowden, L. E. Wagenknecht, A. Balasubramanyam, C. Langfeld, M. F. Saad, J. I. Rotter, X. Guo, Y.-D. I. Chen, M. Bryer-Ash, et al. Associations of Adiponectin with Body Fat Distribution and Insulin Sensitivity in Nondiabetic Hispanics and African-Americans J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2665 - 2671. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Shibata, K. Sato, M. Kumada, Y. Izumiya, M. Sonoda, S. Kihara, N. Ouchi, and K. Walsh Adiponectin accumulates in myocardial tissue that has been damaged by ischemia-reperfusion injury via leakage from the vascular compartment Cardiovasc Res, June 1, 2007; 74(3): 471 - 479. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Norja, L. Nuutila, P. J Karhunen, and S. Goebeler C-reactive protein in vulnerable coronary plaques J. Clin. Pathol., May 1, 2007; 60(5): 545 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Szmitko, H. Teoh, D. J. Stewart, and S. Verma Adiponectin and cardiovascular disease: state of the art? Am J Physiol Heart Circ Physiol, April 1, 2007; 292(4): H1655 - H1663. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Hopkins, N. Ouchi, R. Shibata, and K. Walsh Adiponectin actions in the cardiovascular system Cardiovasc Res, April 1, 2007; 74(1): 11 - 18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Dentali, E. Romualdi, and W. Ageno The metabolic syndrome and the risk of thrombosis Haematologica, March 1, 2007; 92(3): 297 - 299. [Full Text] [PDF]
|
|
|
|
|
|
F. Blaschke, Y. Takata, E. Caglayan, A. Collins, P. Tontonoz, W. A. Hsueh, and R. K. Tangirala A Nuclear Receptor Corepressor-Dependent Pathway Mediates Suppression of Cytokine-Induced C-Reactive Protein Gene Expression by Liver X Receptor Circ. Res., December 8, 2006; 99(12): e88 - e99. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Remuzzi and G. Remuzzi Review: Potential protective effects of telmisartan on renal function deterioration Journal of Renin-Angiotensin-Aldosterone System, December 1, 2006; 7(4): 185 - 191. [Abstract] [PDF]
|
|
|
|
|
|
J. C. Winer, T. L. Zern, S. E. Taksali, J. Dziura, A. M. G. Cali, M. Wollschlager, A. A. Seyal, R. Weiss, T. S. Burgert, and S. Caprio Adiponectin in Childhood and Adolescent Obesity and Its Association with Inflammatory Markers and Components of the Metabolic Syndrome J. Clin. Endocrinol. Metab., November 1, 2006; 91(11): 4415 - 4423. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J F Colombel, C A Solem, W J Sandborn, F Booya, E V Loftus Jr, W S Harmsen, A R Zinsmeister, K D Bodily, and J G Fletcher Quantitative measurement and visual assessment of ileal Crohn's disease activity by computed tomography enterography: correlation with endoscopic severity and C reactive protein Gut, November 1, 2006; 55(11): 1561 - 1567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Koenig, N. Khuseyinova, J. Baumert, C. Meisinger, and H. Lowel Serum Concentrations of Adiponectin and Risk of Type 2 Diabetes Mellitus and Coronary Heart Disease in Apparently Healthy Middle-Aged Men: Results From the 18-Year Follow-Up of a Large Cohort From Southern Germany J. Am. Coll. Cardiol., October 3, 2006; 48(7): 1369 - 1377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J George, S Patal, D Wexler, Y Sharabi, E Peleg, Y Kamari, E Grossman, D Sheps, G Keren, and A Roth Circulating adiponectin concentrations in patients with congestive heart failure Heart, October 1, 2006; 92(10): 1420 - 1424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Bajaj and O. Ben-Yehuda A Big Fat Wedding: Association of Adiponectin With Coronary Vascular Lesions J. Am. Coll. Cardiol., September 19, 2006; 48(6): 1163 - 1165. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Herder, H. Hauner, B. Haastert, K. Rohrig, W. Koenig, H. Kolb, S. Muller-Scholze, B. Thorand, R. Holle, and W. Rathmann Hypoadiponectinemia and Proinflammatory State: Two Sides of the Same Coin?: Results From the Cooperative Health Research in the Region of Augsburg Survey 4 (KORA S4) Diabetes Care, July 1, 2006; 29(7): 1626 - 1631. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Wernstedt, B. Olsson, M. Jernas, S. Paglialunga, L. M. S. Carlsson, U. Smith, K. Cianflone, K. Wallenius, and V. Wallenius Increased Levels of Acylation-Stimulating Protein in Interleukin-6-Deficient (IL-6-/-) Mice Endocrinology, June 1, 2006; 147(6): 2690 - 2695. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ghazalpour, X. Wang, A. J. Lusis, and M. Mehrabian Complex Inheritance of the 5-Lipoxygenase Locus Influencing Atherosclerosis in Mice Genetics, June 1, 2006; 173(2): 943 - 951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. von Eynatten, A. Hamann, D. Twardella, P. P. Nawroth, H. Brenner, and D. Rothenbacher Relationship of Adiponectin with Markers of Systemic Inflammation, Atherogenic Dyslipidemia, and Heart Failure in Patients with Coronary Heart Disease Clin. Chem., May 1, 2006; 52(5): 853 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ekmekci and O. B. Ekmekci The Role of Adiponectin in Atherosclerosis and Thrombosis Clinical and Applied Thrombosis/Hemostasis, April 1, 2006; 12(2): 163 - 168. [Abstract] [PDF]
|
|
|
|
|
|
S.-R. Ji, Y. Wu, L. A. Potempa, Y.-H. Liang, and J. Zhao Effect of Modified C-Reactive Protein on Complement Activation: A Possible Complement Regulatory Role of Modified or Monomeric C-Reactive Protein in Atherosclerotic Lesions Arterioscler Thromb Vasc Biol, April 1, 2006; 26(4): 935 - 941. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Jialal, S. Devaraj, U. Singh, J. Fan, and Y. E. Chen Sources of CRP in Atherosclerotic Lesions Am. J. Pathol., March 1, 2006; 168(3): 1054 - 1056. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Furuya, M. Odamaki, H. Kumagai, and A. Hishida Beneficial effects of icodextrin on plasma level of adipocytokines in peritoneal dialysis patients Nephrol. Dial. Transplant., February 1, 2006; 21(2): 494 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Schalkwijk, N. Chaturvedi, M. T. Schram, J. H. Fuller, C. D. A. Stehouwer, and the EURODIAB Prospective Complications Study Group Adiponectin Is Inversely Associated with Renal Function in Type 1 Diabetic Patients J. Clin. Endocrinol. Metab., January 1, 2006; 91(1): 129 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kato, H. Kashiwagi, M. Shiraga, S. Tadokoro, T. Kamae, H. Ujiie, S. Honda, S. Miyata, Y. Ijiri, J. Yamamoto, et al. Adiponectin Acts as an Endogenous Antithrombotic Factor Arterioscler Thromb Vasc Biol, January 1, 2006; 26(1): 224 - 230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Takemura, Y. Osuga, M. Harada, T. Hirata, K. Koga, C. Morimoto, Y. Hirota, O. Yoshino, T. Yano, and Y. Taketani Serum adiponectin concentrations are decreased in women with endometriosis Hum. Reprod., December 1, 2005; 20(12): 3510 - 3513. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. M. van Ree, A. P. J. de Vries, L. H. Oterdoom, T. H. The, R. T. Gansevoort, J. J. Homan van der Heide, W. J. van Son, R. J. Ploeg, P. E. de Jong, R. O. B. Gans, et al. Abdominal obesity and smoking are important determinants of C-reactive protein in renal transplant recipients Nephrol. Dial. Transplant., November 1, 2005; 20(11): 2524 - 2531. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. R. Manigrasso, P. Ferroni, F. Santilli, T. Taraborelli, M. T. Guagnano, N. Michetti, and G. Davi Association between Circulating Adiponectin and Interleukin-10 Levels in Android Obesity: Effects of Weight Loss J. Clin. Endocrinol. Metab., October 1, 2005; 90(10): 5876 - 5879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Calabro, D. W. Chang, J. T. Willerson, and E. T.H. Yeh Release of C-Reactive Protein in Response to Inflammatory Cytokines by Human Adipocytes: Linking Obesity to Vascular Inflammation J. Am. Coll. Cardiol., September 20, 2005; 46(6): 1112 - 1113. [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Schwedler, K. Amann, K. Wernicke, A. Krebs, M. Nauck, C. Wanner, L. A. Potempa, and J. Galle Native C-Reactive Protein Increases Whereas Modified C-Reactive Protein Reduces Atherosclerosis in Apolipoprotein E-Knockout Mice Circulation, August 16, 2005; 112(7): 1016 - 1023. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Rothenbacher, H. Brenner, W. Marz, and W. Koenig Adiponectin, risk of coronary heart disease and correlations with cardiovascular risk markers Eur. Heart J., August 2, 2005; 26(16): 1640 - 1646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. Mantzoros, T. Li, J. E. Manson, J. B. Meigs, and F. B. Hu Circulating Adiponectin Levels Are Associated with Better Glycemic Control, More Favorable Lipid Profile, and Reduced Inflammation in Women with Type 2 Diabetes J. Clin. Endocrinol. Metab., August 1, 2005; 90(8): 4542 - 4548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K Yamamoto, T Kiyohara, Y Murayama, S Kihara, Y Okamoto, T Funahashi, T Ito, R Nezu, S Tsutsui, J-I Miyagawa, et al. Production of adiponectin, an anti-inflammatory protein, in mesenteric adipose tissue in Crohn's disease Gut, June 1, 2005; 54(6): 789 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Saraheimo, C. Forsblom, J. Fagerudd, A.-M. Teppo, K. Pettersson-Fernholm, J. Frystyk, A. Flyvbjerg, P.-H. Groop, and on behalf of the FinnDiane Study Group Serum Adiponectin Is Increased in Type 1 Diabetic Patients With Nephropathy Diabetes Care, June 1, 2005; 28(6): 1410 - 1414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Koh, S. H. Han, M. J. Quon, J. Yeal Ahn, and E. K. Shin Beneficial Effects of Fenofibrate to Improve Endothelial Dysfunction and Raise Adiponectin Levels in Patients With Primary Hypertriglyceridemia Diabetes Care, June 1, 2005; 28(6): 1419 - 1424. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Iwashima, T. Katsuya, K. Ishikawa, I. Kida, M. Ohishi, T. Horio, N. Ouchi, K. Ohashi, S. Kihara, T. Funahashi, et al. Association of Hypoadiponectinemia With Smoking Habit in Men Hypertension, June 1, 2005; 45(6): 1094 - 1100. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Otake, H. Takeda, Y. Suzuki, T. Fukui, S. Watanabe, K. Ishihama, T. Saito, H. Togashi, T. Nakamura, Y. Matsuzawa, et al. Association of Visceral Fat Accumulation and Plasma Adiponectin with Colorectal Adenoma: Evidence for Participation of Insulin Resistance Clin. Cancer Res., May 15, 2005; 11(10): 3642 - 3646. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Berg and P. E. Scherer Adipose Tissue, Inflammation, and Cardiovascular Disease Circ. Res., May 13, 2005; 96(9): 939 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. W. Lau, B. Dhillon, H. Yan, P. E. Szmitko, and S. Verma Adipokines: molecular links between obesity and atheroslcerosis Am J Physiol Heart Circ Physiol, May 1, 2005; 288(5): H2031 - H2041. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Ouchi, R. Shibata, and K. Walsh AMP-Activated Protein Kinase Signaling Stimulates VEGF Expression and Angiogenesis in Skeletal Muscle Circ. Res., April 29, 2005; 96(8): 838 - 846. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Nicklas, T. You, and M. Pahor Behavioural treatments for chronic systemic inflammation: effects of dietary weight loss and exercise training Can. Med. Assoc. J., April 26, 2005; 172(9): 1199 - 1209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-P. Chen, J. C.-R. Tsai, F.-M. Chung, S.-S. Yang, L.-L. Hsing, S.-J. Shin, and Y.-J. Lee Hypoadiponectinemia Is Associated With Ischemic Cerebrovascular Disease Arterioscler Thromb Vasc Biol, April 1, 2005; 25(4): 821 - 826. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Maahs, L. G. Ogden, G. L. Kinney, P. Wadwa, J. K. Snell-Bergeon, D. Dabelea, J. E. Hokanson, J. Ehrlich, R. H. Eckel, and M. Rewers Low Plasma Adiponectin Levels Predict Progression of Coronary Artery Calcification Circulation, February 15, 2005; 111(6): 747 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Greenfield, K. Samaras, C. S. Hayward, D. J. Chisholm, and L. V. Campbell Beneficial Postprandial Effect of a Small Amount of Alcohol on Diabetes and Cardiovascular Risk Factors: Modification by Insulin Resistance J. Clin. Endocrinol. Metab., February 1, 2005; 90(2): 661 - 672. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. B. Schulze, I. Shai, E. B. Rimm, T. Li, N. Rifai, and F. B. Hu Adiponectin and Future Coronary Heart Disease Events Among Men With Type 2 Diabetes Diabetes, February 1, 2005; 54(2): 534 - 539. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. von Eynatten, J. G. Schneider, P. M. Humpert, G. Rudofsky, N. Schmidt, P. Barosch, A. Hamann, M. Morcos, J. Kreuzer, A. Bierhaus, et al. Decreased Plasma Lipoprotein Lipase in Hypoadiponectinemia: An association independent of systemic inflammation and insulin resistance Diabetes Care, December 1, 2004; 27(12): 2925 - 2929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. Shetty, P. A. Economides, E. S. Horton, C. S. Mantzoros, and A. Veves Circulating Adiponectin and Resistin Levels in Relation to Metabolic Factors, Inflammatory Markers, and Vascular Reactivity in Diabetic Patients and Subjects at Risk for Diabetes Diabetes Care, October 1, 2004; 27(10): 2450 - 2457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Prasad and A. A. Quyyumi Renin-Angiotensin System and Angiotensin Receptor Blockers in the Metabolic Syndrome Circulation, September 14, 2004; 110(11): 1507 - 1512. [Full Text] [PDF]
|
|
|
|
|
|
B. B. Duncan, M. I. Schmidt, J. S. Pankow, H. Bang, D. Couper, C. M. Ballantyne, R. C. Hoogeveen, and G. Heiss Adiponectin and the Development of Type 2 Diabetes: The Atherosclerosis Risk in Communities Study Diabetes, September 1, 2004; 53(9): 2473 - 2478. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. D. Kriketos, J. R. Greenfield, P. W. Peake, S. M. Furler, G. S. Denyer, J. A. Charlesworth, and L. V. Campbell Inflammation, Insulin Resistance, and Adiposity: A study of first-degree relatives of type 2 diabetic subjects Diabetes Care, August 1, 2004; 27(8): 2033 - 2040. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Rutter, J. B. Meigs, L. M. Sullivan, R. B. D'Agostino Sr, and P. W.F. Wilson C-Reactive Protein, the Metabolic Syndrome, and Prediction of Cardiovascular Events in the Framingham Offspring Study Circulation, July 27, 2004; 110(4): 380 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Mills and D. L. Bhatt The yin and yang of arterial inflammation J. Am. Coll. Cardiol., July 7, 2004; 44(1): 50 - 52. [Full Text] [PDF]
|
|
|
|
|
|
M. B. Schulze, E. B. Rimm, I. Shai, N. Rifai, and F. B. Hu Relationship Between Adiponectin and Glycemic Control, Blood Lipids, and Inflammatory Markers in Men With Type 2 Diabetes Diabetes Care, July 1, 2004; 27(7): 1680 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Greenfield, K. Samaras, A. B. Jenkins, P. J. Kelly, T. D. Spector, J. R. Gallimore, M. B. Pepys, and L. V. Campbell Obesity Is an Important Determinant of Baseline Serum C-Reactive Protein Concentration in Monozygotic Twins, Independent of Genetic Influences Circulation, June 22, 2004; 109(24): 3022 - 3028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Sutinen, K. Kannisto, E. Korsheninnikova, R. M. Fisher, E. Ehrenborg, T. Nyman, A. Virkamaki, T. Funahashi, Y. Matsuzawa, H. Vidal, et al. Effects of rosiglitazone on gene expression in subcutaneous adipose tissue in highly active antiretroviral therapy-associated lipodystrophy Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E941 - E949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kumada, S. Kihara, N. Ouchi, H. Kobayashi, Y. Okamoto, K. Ohashi, K. Maeda, H. Nagaretani, K. Kishida, N. Maeda, et al. Adiponectin Specifically Increased Tissue Inhibitor of Metalloproteinase-1 Through Interleukin-10 Expression in Human Macrophages Circulation, May 4, 2004; 109(17): 2046 - 2049. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Pischon, C. J. Girman, G. S. Hotamisligil, N. Rifai, F. B. Hu, and E. B. Rimm Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men JAMA, April 14, 2004; 291(14): 1730 - 1737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shinohara, A. Wakatsuki, K. Watanabe, N. Ikenoue, T. Fukaya, N. Sattar, J. Ramsey, N. Jamieson, and I. A. Greer Plasma Adiponectin Concentrations in Women With Preeclampsia * Response: Adiponectin Concentrations in Preeclampsia Hypertension, April 1, 2004; 43(4): e17 - e17. [Full Text] [PDF]
|
|
|
|
|
|
K. C. B. Tan, A. Xu, W. S. Chow, M. C. W. Lam, V. H. G. Ai, S. C. F. Tam, and K. S. L. Lam Hypoadiponectinemia Is Associated with Impaired Endothelium-Dependent Vasodilation J. Clin. Endocrinol. Metab., February 1, 2004; 89(2): 765 - 769. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Mazurek, L. Zhang, A. Zalewski, J. D. Mannion, J. T. Diehl, H. Arafat, L. Sarov-Blat, S. O'Brien, E. A. Keiper, A. G. Johnson, et al. Human Epicardial Adipose Tissue Is a Source of Inflammatory Mediators Circulation, November 18, 2003; 108(20): 2460 - 2466. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Turk, J. A. Carroll, M. H. Laughlin, T. R. Thomas, J. Casati, D. K. Bowles, and M. Sturek C-reactive protein correlates with macrophage accumulation in coronary arteries of hypercholesterolemic pigs J Appl Physiol, September 1, 2003; 95(3): 1301 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Chandran, S. A. Phillips, T. Ciaraldi, and R. R. Henry Adiponectin: More Than Just Another Fat Cell Hormone? Diabetes Care, August 1, 2003; 26(8): 2442 - 2450. [Full Text] [PDF]
|
|
|
|
|
|
J. Krakoff, T. Funahashi, C. D.A. Stehouwer, C. G. Schalkwijk, S. Tanaka, Y. Matsuzawa, S. Kobes, P. A. Tataranni, R. L. Hanson, W. C. Knowler, et al. Inflammatory Markers, Adiponectin, and Risk of Type 2 Diabetes in the Pima Indian Diabetes Care, June 1, 2003; 26(6): 1745 - 1751. [Abstract] [Full Text] [PDF]
|
|