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(Circulation. 2003;107:2331.)
© 2003 American Heart Association, Inc.

Clinical Investigation and Reports

Treatment of Saphenous Vein Bypass Grafts With Ultrasound Thrombolysis

A Randomized Study (ATLAS)

Mandeep Singh, MD; Uri Rosenschein, MD; Kalon K.L. Ho, MD; Peter B. Berger, MD; Richard Kuntz, MD; David R. Holmes, Jr, MD

From the Division of Cardiovascular Diseases and Internal Medicine (M.S., P.B.B., D.R.H.), Mayo Clinic, Rochester, Minn; Tel Aviv Medical Center (U.R.), Tel Aviv, Israel; Beth Israel Deaconess Medical Center (K.K.L.H.), Boston, Mass; and Brigham and Women’s Hospital (R.K.), Boston, Mass.

Correspondence to David R. Holmes, Jr, MD, Division of Cardiovascular Diseases and Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905.

Background— Percutaneous coronary interventions (PCIs) in saphenous vein grafts (SVGs) with thrombus have a high frequency of distal embolization. Acolysis (therapeutic ultrasound) can break up thrombus in vitro in animal models and humans. Whether this is beneficial during percutaneous SVG interventions is unknown.

Methods and Results— We performed a trial of coronary ultrasound thrombolysis in which patients with an acute coronary syndrome undergoing PCI in SVGs were randomly assigned to receive acolysis or abciximab. The primary end point was a successful procedure, defined as final luminal diameter stenosis 30% or less with Thrombolysis In Myocardial Infarction grade 3 flow and freedom from major adverse cardiac events (composite of death, Q-wave, and non–Q-wave myocardial infarction [MI], emergency bypass procedure, disabling stroke, and target lesion revascularization). Of 181 enrolled, 92 received acolysis and 89 abciximab. Angiographic procedural success was achieved in 63% of acolysis patients and 82% of abciximab patients (P=0.008). Incidence of major adverse cardiac events at 30 days was 25% with acolysis and 12% with abciximab (P=0.036), attributable mainly to a greater frequency of non–Q-wave MI with acolysis (19.6% versus 7.9%, P=0.03). The incidence of Q-wave MI was also higher with acolysis (5.4% versus 2.2%, P=nonsignificant). The primary end point was achieved in 53.8% of acolysis patients and 73.1% of abciximab patients (P=0.014).

Conclusions— Use of therapeutic ultrasound in vein graft lesions in patients with acute coronary syndrome had poor angiographic outcome and increased the incidence of acute ischemic complications.

Key Words: angioplasty • thrombolysis • ultrasonics

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Percutaneous Treatment of Saphenous Vein Bypass Graft Obstructions: A Continuing Obstinate Problem

P.J. de Feyter
Circulation 2003 107: 2284-2286. [Extract] [Full Text]

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