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(Circulation. 2003;107:2021.)
© 2003 American Heart Association, Inc.

Clinical Investigation and Reports

ß₂-Adrenergic Receptor Polymorphisms and Risk of Incident Cardiovascular Events in the Elderly

Susan R. Heckbert, MD, PhD; Lucia A. Hindorff, MPH; Karen L. Edwards, PhD; Bruce M. Psaty, MD, PhD; Thomas Lumley, PhD; David S. Siscovick, MD, MPH; Zhonghua Tang, PhD; J. Peter Durda, BS; Richard A. Kronmal, PhD; Russell P. Tracy, PhD

From the Departments of Epidemiology (S.R.H., L.A.H., K.L.E., B.M.P., D.S.S.), Medicine (B.M.P., D.S.S.), and Biostatistics (T.L., R.A.K.), University of Washington, Seattle, Wash, and Department of Pathology (Z.T., J.P.D., R.P.T.), University of Vermont, Burlington, Vt. Z. Tang is now at the Department of Medicine, Thomas Jefferson University, Philadelphia, Pa.

Correspondence to Susan R. Heckbert, MD, PhD, 1730 Minor Ave, Suite 1360, Seattle, WA 98101-1448. E-mail heckbert{at}u.washington.edu

Background— Genetic polymorphisms at codons 16 and 27 of the ß₂-adrenergic receptor have been associated with altered response to sympathetic stimulation. We examined these polymorphisms in relation to cardiovascular event risk in the Cardiovascular Health Study.

Methods and Results— A total of 808 black and 4441 white participants (mean age, 73 years) were genotyped for the Arg16Gly and Gln27Glu polymorphisms of the ß₂-adrenergic receptor. There were 702 incident coronary events, 438 ischemic strokes, and 1136 combined cardiovascular events during 7 to 10 years of follow-up. Allele frequencies differed by race but not by age or hypertension status. Glu27 carriers had a lower risk of coronary events than Gln27 homozygotes (hazard ratio, 0.82; 95% CI, 0.70 to 0.95), and there was a suggestion of decreased risk among Gly16 carriers compared with Arg16 homozygotes (hazard ratio, 0.88; 95% CI, 0.72 to 1.07). There was no association of ß₂-adrenergic receptor genotype with ischemic stroke or combined cardiovascular events.

Conclusions— The Glu27 allele of the ß₂-adrenergic receptor was associated with a lower risk of incident coronary events in this elderly population.

Key Words: coronary disease • epidemiology • genetics • hypertension • stroke

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