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(Circulation. 2002;106:1043.)
© 2002 American Heart Association, Inc.

Special Reports

Recommendations of the National Heart, Lung, and Blood Institute Heart and Lung Xenotransplantation Working Group

Jeffrey Platt, MD; Verdi DiSesa, MD; Dorothy Gail, PhD; Judith Massicot-Fisher, PhD

From the Departments of Surgery, Immunology, and Pediatrics, Mayo Clinic, Rochester, Minn (J.P.); the Section of Cardiac Surgery, Department of Surgery, The Chester County Hospital, West Chester, Pa (V.D.); and Division of Lung Diseases (D.G.), Division of Heart and Vascular Diseases (J.M.-F.), National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md (D.G., J.M.-F.).

Correspondence to Judith Massicot-Fisher, PhD, National Heart, Lung, and Blood Institute, 6701 Rockledge Dr, MSC 7940, Bethesda, MD 20892-7940. E-mail JM294Z{at}NIH.gov

Abstract

The National Heart, Lung, and Blood Institute (NHLBI) recently convened the Heart and Lung Xenotransplantation Working Group to identify hurdles to the clinical application of xenotransplantation, defined as the use of animal organs or tissue for transplantation, and to recommend possible solutions to these problems. The group consisted of experts in xenotransplantation from academia, industry, and federal agencies, and the discussions focused on those areas within the mission of the NHLBI. The areas covered included immunologic and physiological barriers to xenotransplantation, the limitations of the current animal models, the need for collaboration among groups, the high costs of studies using nonhuman primates and genetic engineering of pigs, and the unique problems of lung xenotransplantation. This report is a summary of those discussions.

Key Words: heart failure • National Institutes of Health • pulmonary disease • transplantation • transplantation, heterologous

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