Circulation. 2002;106:804-808
Published online before print July 22, 2002, doi: 10.1161/01.CIR.0000025609.13806.31
Published online before print July 22, 2002, doi: 10.1161/01.CIR.0000025609.13806.31
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2002;106:804.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Multiple Atherosclerotic Plaque Rupture in Acute Coronary Syndrome
A Three-Vessel Intravascular Ultrasound Study
From the Department of Hemodynamics, Cardiovascular Hospital and Claude Bernard University, Lyon (G.R., G.F., I.G., X.A.-F., R.R., A.T.); Department of Cardiology, Centre Hospitalier d’Annecy, Annecy (E.V., E.D.); Department of Cardiology, Centre Hospitalier de Roanne, Roanne (G.C.); and Department of Cardiology, Centre Hospitalier de Valence, Valence (J.F.H.), France.
Correspondence to Gilles Rioufol, MD, PhD, Department of Hemodynamics, Cardiovascular Hospital, B.P Lyon-Monchat, 69394 Lyon Cedex 03, France. E-mail gilles.rioufol{at}univ-lyon1.fr
Background— To test the hypothesis of general atherosclerotic plaque destabilization during acute coronary syndrome (ACS), the present study sought to analyze the 3 coronary arteries by systematic intravascular ultrasound scan (IVUS).
Methods and Results— Seventy-two arteries were explored in 24 patients referred for percutaneous coronary intervention after a first ACS with troponin I elevation. Fifty plaque ruptures (mean, 2.08 per patient; range, 0 to 6) were diagnosed by the association of a ruptured capsule with intraplaque cavity. Plaque rupture on the culprit lesion was found in 9 patients (37.5%). At least 1 plaque rupture was found somewhere other than on the culprit lesion in 19 patients (79%). These lesions were in a different artery than the culprit artery in 70.8% and were in both other arteries in 12.5% of these 24 patients. Complete IVUS examination of all 3 coronary axes in patients who had experienced a first ACS revealed that multiple atherosclerotic plaque ruptures were detected by IVUS; these multiple ruptures were present simultaneously with the culprit lesion; they were frequent and located (in three quarters of cases) on the 3 principal coronary trunks; and the multiple plaque ruptures in locations other than on the culprit lesion were less severe, nonstenosing, and less calcified.
Conclusion— Although one single lesion is clinically active at the time of ACS, the syndrome seems nevertheless associated with overall coronary instability.
Key Words: ultrasonics • atherosclerosis • plaque • coronary disease
This article has been cited by other articles:
 |
|
 |
|
  A. Maehara, G. S. Mintz, and N. J. Weissman Advances in Intravascular Imaging Circ Cardiovasc Interv, October 1, 2009; 2(5): 482 - 490. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kumar and C. P. Cannon Acute Coronary Syndromes: Diagnosis and Management, Part I Mayo Clin. Proc., October 1, 2009; 84(10): 917 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Bayturan, E. M. Tuzcu, S. J. Nicholls, C. Balog, A. Lavoie, K. Uno, T. D. Crowe, W. A. Magyar, K. Wolski, S. Kapadia, et al. Attenuated Plaque at Nonculprit Lesions in Patients Enrolled in Intravascular Ultrasound Atherosclerosis Progression Trials J. Am. Coll. Cardiol. Intv., July 1, 2009; 2(7): 672 - 678. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. H.F. Rudd, F. Hyafil, and Z. A. Fayad Inflammation Imaging in Atherosclerosis Arterioscler Thromb Vasc Biol, July 1, 2009; 29(7): 1009 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Sparrow, N. Merchant, Y. L. Provost, D. J. Doyle, E. T. Nguyen, and N. S. Paul CT and MR Imaging Findings in Patients with Acquired Heart Disease at Risk for Sudden Cardiac Death1 RadioGraphics, May 1, 2009; 29(3): 805 - 823. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. J. Hong, M. H. Jeong, Y. H. Choi, J. S. Ko, M. G. Lee, W. Y. Kang, S. E. Lee, S. H. Kim, K. H. Park, D. S. Sim, et al. Plaque characteristics in culprit lesions and inflammatory status in diabetic acute coronary syndrome patients. J. Am. Coll. Cardiol. Img., March 1, 2009; 2(3): 339 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kitagawa, H. Yamamoto, J. Horiguchi, N. Ohhashi, F. Tadehara, T. Shokawa, Y. Dohi, E. Kunita, H. Utsunomiya, N. Kohno, et al. Characterization of noncalcified coronary plaques and identification of culprit lesions in patients with acute coronary syndrome by 64-slice computed tomography. J. Am. Coll. Cardiol. Img., February 1, 2009; 2(2): 153 - 160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Loponen, K. Korpilahti, M. Luther, H. Huhtala, and M. R. Tarkka Repeat intervention after invasive treatment of coronary arteries Eur. J. Cardiothorac. Surg., January 1, 2009; 35(1): 43 - 47. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Y. Lee, G. S. Mintz, S.-Y. Kim, Y. J. Hong, S. W. Kim, T. Okabe, A. D. Pichard, L. F. Satler, K. M. Kent, W. O. Suddath, et al. Attenuated Plaque Detected by Intravascular Ultrasound: Clinical, Angiographic, and Morphologic Features and Post-Percutaneous Coronary Intervention Complications in Patients With Acute Coronary Syndromes J. Am. Coll. Cardiol. Intv., January 1, 2009; 2(1): 65 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Pundziute, J. D. Schuijf, J. W. Jukema, I. Decramer, G. Sarno, P. K. Vanhoenacker, E. Boersma, J. H.C. Reiber, M. J. Schalij, W. Wijns, et al. Evaluation of plaque characteristics in acute coronary syndromes: non-invasive assessment with multi-slice computed tomography and invasive evaluation with intravascular ultrasound radiofrequency data analysis Eur. Heart J., October 1, 2008; 29(19): 2373 - 2381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Waksman, P. E. McEwan, T. I. Moore, R. Pakala, F. D. Kolodgie, D. G. Hellinga, R. C. Seabron, S. J. Rychnovsky, J. Vasek, R. W. Scott, et al. PhotoPoint Photodynamic Therapy Promotes Stabilization of Atherosclerotic Plaques and Inhibits Plaque Progression J. Am. Coll. Cardiol., September 16, 2008; 52(12): 1024 - 1032. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Gardner, H. Tan, E. L. Hull, J. B. Lisauskas, S. T. Sum, T. M. Meese, C. Jiang, S. P. Madden, J. D. Caplan, A. P. Burke, et al. Detection of lipid core coronary plaques in autopsy specimens with a novel catheter-based near-infrared spectroscopy system. J. Am. Coll. Cardiol. Img., September 1, 2008; 1(5): 638 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ohayon, G. Finet, A. M. Gharib, D. A. Herzka, P. Tracqui, J. Heroux, G. Rioufol, M. S. Kotys, A. Elagha, and R. I. Pettigrew Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H717 - H727. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Biasucci, M. Leo, and G. L. De Maria Local and Systemic Mechanisms of Plaque Rupture Angiology, August 1, 2008; 59(2_suppl): 73S - 76S. [Abstract] [PDF]
|
|
|
|
|
|
Y. J. Hong, M. H. Jeong, Y. Ahn, D. S. Sim, J. W. Chung, J. S. Cho, N. S. Yoon, H. J. Yoon, J. Y. Moon, K. H. Kim, et al. Plaque prolapse after stent implantation in patients with acute myocardial infarction an intravascular ultrasound analysis. J. Am. Coll. Cardiol. Img., July 1, 2008; 1(4): 489 - 497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Foglieni, F. Maisano, L. Dreas, A. Giazzon, G. Ruotolo, E. Ferrero, L. Li Volsi, S. Coli, G. Sinagra, B. Zingone, et al. Mild inflammatory activation of mammary arteries in patients with acute coronary syndromes Am J Physiol Heart Circ Physiol, June 1, 2008; 294(6): H2831 - H2837. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. O. Caymaz and G. Yuksel Fate of Incidental, Asymptomatic Lesions Discovered During Percutaneous Coronary Intervention Angiology, May 1, 2008; 59(2): 193 - 197. [Abstract] [PDF]
|
|
|
|
|
|
T. J. Bunch, C. S. Rihal, R. J. Gumina, L. Cooper, and N. M. Caplice Progression of Nonculprit Plaque Stenosis Following Successful Percutaneous Intervention Angiology, May 1, 2008; 59(2): 236 - 239. [Abstract] [PDF]
|
|
|
|
|
|
J. A. Ambrose In Search of the "vulnerable plaque": can it be localized and will focal regional therapy ever be an option for cardiac prevention? J. Am. Coll. Cardiol., April 22, 2008; 51(16): 1539 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tanaka, K. Shimada, M. Namba, T. Sakamoto, Y. Nakamura, Y. Nishida, J. Yoshikawa, and T. Akasaka Relationship between longitudinal morphology of ruptured plaques and TIMI flow grade in acute coronary syndrome: a three-dimensional intravascular ultrasound imaging study Eur. Heart J., January 1, 2008; 29(1): 38 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Takumi, S. Lee, S. Hamasaki, K. Toyonaga, D. Kanda, K. Kusumoto, H. Toda, T. Takenaka, M. Miyata, R. Anan, et al. Limitation of Angiography to Identify the Culprit Plaque in Acute Myocardial Infarction With Coronary Total Occlusion: Utility of Coronary Plaque Temperature Measurement to Identify the Culprit Plaque J. Am. Coll. Cardiol., December 4, 2007; 50(23): 2197 - 2203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Okura, H. Taguchi, T. Kubo, I. Toda, M. Yoshiyama, J. Yoshikawa, and K. Yoshida Impact of arterial remodelling and plaque rupture on target and non-target lesion revascularisation after stent implantation in patients with acute coronary syndrome: an intravascular ultrasound study Heart, October 1, 2007; 93(10): 1219 - 1225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kubo, T. Imanishi, S. Takarada, A. Kuroi, S. Ueno, T. Yamano, T. Tanimoto, Y. Matsuo, T. Masho, H. Kitabata, et al. Assessment of Culprit Lesion Morphology in Acute Myocardial Infarction: Ability of Optical Coherence Tomography Compared With Intravascular Ultrasound and Coronary Angioscopy J. Am. Coll. Cardiol., September 4, 2007; 50(10): 933 - 939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. W. Serruys, H. M. Garcia-Garcia, and E. Regar From Postmortem Characterization to the In Vivo Detection of Thin-Capped Fibroatheromas: The Missing Link Toward Percutaneous Treatment: What If Diogenes Would Have Found What He Was Looking For? J. Am. Coll. Cardiol., September 4, 2007; 50(10): 950 - 952. [Full Text] [PDF]
|
|
|
|
|
|
P. K. Cheruvu, A. V. Finn, C. Gardner, J. Caplan, J. Goldstein, G. W. Stone, R. Virmani, and J. E. Muller Frequency and Distribution of Thin-Cap Fibroatheroma and Ruptured Plaques in Human Coronary Arteries: A Pathologic Study J. Am. Coll. Cardiol., September 4, 2007; 50(10): 940 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ohayon, O. Dubreuil, P. Tracqui, S. Le Floc'h, G. Rioufol, L. Chalabreysse, F. Thivolet, R. I. Pettigrew, and G. Finet Influence of residual stress/strain on the biomechanical stability of vulnerable coronary plaques: potential impact for evaluating the risk of plaque rupture Am J Physiol Heart Circ Physiol, September 1, 2007; 293(3): H1987 - H1996. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Konig and V. Klauss Virtual histology Heart, August 1, 2007; 93(8): 977 - 982. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Authors/Task Force Members, J.-P. Bassand, C. W. Hamm, D. Ardissino, E. Boersma, A. Budaj, F. Fernandez-Aviles, K. A.A. Fox, D. Hasdai, E. M. Ohman, et al. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes: The Task Force for the Diagnosis and Treatment of Non-ST-Segment Elevation Acute Coronary Syndromes of the European Society of Cardiology Eur. Heart J., July 1, 2007; 28(13): 1598 - 1660. [Full Text] [PDF]
|
|
|
|
|
|
P. Schoenhagen Plaque Temperature, Arterial Remodeling, and Inflammation: Understanding "Hot-Spots" in the Coronary Arteries J. Am. Coll. Cardiol., June 12, 2007; 49(23): 2272 - 2273. [Full Text] [PDF]
|
|
|
|
|
|
K. Toutouzas, A. Synetos, E. Stefanadi, S. Vaina, V. Markou, M. Vavuranakis, E. Tsiamis, D. Tousoulis, and C. Stefanadis Correlation Between Morphologic Characteristics and Local Temperature Differences in Culprit Lesions of Patients With Symptomatic Coronary Artery Disease J. Am. Coll. Cardiol., June 12, 2007; 49(23): 2264 - 2271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. K. Mehta, J. R. McCrary, A. D. Frutkin, W. J.S. Dolla, and S. P. Marso Intravascular ultrasound radiofrequency analysis of coronary atherosclerosis: an emerging technology for the assessment of vulnerable plaque Eur. Heart J., June 1, 2007; 28(11): 1283 - 1288. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Steinhubl, J. J. Badimon, D. L. Bhatt, J.-M. Herbert, and T. F. Luscher Clinical evidence for anti-inflammatory effects of antiplatelet therapy in patients with atherothrombotic disease Vascular Medicine, May 1, 2007; 12(2): 113 - 122. [Abstract] [PDF]
|
|
|
|
|
|
A. Lerman, D. R. Holmes, J. Herrmann, and B. J. Gersh Microcirculatory dysfunction in ST-elevation myocardial infarction: cause, consequence, or both? Eur. Heart J., April 1, 2007; 28(7): 788 - 797. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Mazzadi, X. Andre-Fouet, N. Costes, P. Croisille, D. Revel, and M. F. Janier Mechanisms leading to reversible mechanical dysfunction in severe CAD: alternatives to myocardial stunning Am J Physiol Heart Circ Physiol, December 1, 2006; 291(6): H2570 - H2582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Waxman, F. Ishibashi, and J. E. Muller Detection and Treatment of Vulnerable Plaques and Vulnerable Patients: Novel Approaches to Prevention of Coronary Events Circulation, November 28, 2006; 114(22): 2390 - 2411. [Full Text] [PDF]
|
|
|
|
 |
|
 E. Van De Graaff, M. Dutta, P. Das, E. A. Shry, P. D. Frederick, M. Blaney, D. J. Pasta, and S. R. Steinhubl Early Coronary Revascularization Diminishes the Risk of Ischemic Stroke With Acute Myocardial Infarction Stroke, October 1, 2006; 37(10): 2546 - 2551. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Ohtani, K. Egashira, Y. Ihara, K. Nakano, K. Funakoshi, G. Zhao, M. Sata, and K. Sunagawa Angiotensin II Type 1 Receptor Blockade Attenuates In-Stent Restenosis by Inhibiting Inflammation and Progenitor Cells Hypertension, October 1, 2006; 48(4): 664 - 670. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Rodriguez-Granillo, H. M. Garcia-Garcia, M. Valgimigli, S. Vaina, C. van Mieghem, R. J. van Geuns, M. van der Ent, E. Regar, P. de Jaegere, W. van der Giessen, et al. Global characterization of coronary plaque rupture phenotype using three-vessel intravascular ultrasound radiofrequency data analysis Eur. Heart J., August 2, 2006; 27(16): 1921 - 1927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Nicholls, E. M. Tuzcu, I. Sipahi, P. Schoenhagen, and S. E. Nissen Intravascular Ultrasound in Cardiovascular Medicine Circulation, July 25, 2006; 114(4): e55 - e59. [Full Text] [PDF]
|
|
|
|
|
|
J. S. Forrester, M. S. Lee, N. Kapoor, and R. R. Makkar The Janus Face of Drug-Eluting Stents J. Am. Coll. Cardiol., July 18, 2006; 48(2): 375 - 376. [Full Text] [PDF]
|
|
|
|
|
|
A. A. Elesber, C. A. Conover, A. E. Denktas, R. J. Lennon, D. R. Holmes Jr, M. T. Overgaard, M. Christiansen, C. Oxvig, L. O. Lerman, and A. Lerman Prognostic value of circulating pregnancy-associated plasma protein levels in patients with chronic stable angina Eur. Heart J., July 2, 2006; 27(14): 1678 - 1684. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ohtani, Y. Ueda, I. Mizote, J. Oyabu, K. Okada, A. Hirayama, and K. Kodama Number of Yellow Plaques Detected in a Coronary Artery Is Associated With Future Risk of Acute Coronary Syndrome: Detection of Vulnerable Patients by Angioscopy J. Am. Coll. Cardiol., June 6, 2006; 47(11): 2194 - 2200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Domanski, K. A. Jablonski, M. M. Rice, S. E. Fowler, E. Braunwald, and for the PEACE Investigators Obesity and cardiovascular events in patients with established coronary disease Eur. Heart J., June 2, 2006; 27(12): 1416 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. J. Gomes and E. Buffolo Coronary stenting and inflammation: implications for further surgical and medical treatment. Ann. Thorac. Surg., May 1, 2006; 81(5): 1918 - 1925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. W. Stone and H. D. Aronow Long-term Care After Percutaneous Coronary Intervention: Focus on the Role of Antiplatelet Therapy Mayo Clin. Proc., May 1, 2006; 81(5): 641 - 652. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. DeMaria, J. Narula, E. Mahmud, and S. Tsimikas Imaging vulnerable plaque by ultrasound. J. Am. Coll. Cardiol., April 18, 2006; 47(8 Suppl): C32 - C39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Braunwald Epilogue: What Do Clinicians Expect From Imagers? J. Am. Coll. Cardiol., April 18, 2006; 47(8S): C101 - C103. [Full Text] [PDF]
|
|
|
|
|
|
C. von Birgelen, M. Hartmann, G. S. Mintz, D. Bose, H. Eggebrecht, T. Neumann, M. Gossl, H. Wieneke, A. Schmermund, M. G. Stoel, et al. Remodeling Index Compared to Actual Vascular Remodeling in Atherosclerotic Left Main Coronary Arteries as Assessed With Long-Term (>=12 Months) Serial Intravascular Ultrasound J. Am. Coll. Cardiol., April 4, 2006; 47(7): 1363 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Sakakura, T. Yasu, Y. Kobayashi, T. Katayama, Y. Sugawara, H. Funayama, Y. Takagi, N. Ikeda, T. Ishida, Y. Tsuruya, et al. Noninvasive Tissue Characterization of Coronary Arterial Plaque by 16-Slice Computed Tomography in Acute Coronary Syndrome Angiology, March 1, 2006; 57(2): 155 - 160. [Abstract] [PDF]
|
|
|
|
|
|
K. Sano, M. Kawasaki, Y. Ishihara, M. Okubo, K. Tsuchiya, K. Nishigaki, X. Zhou, S. Minatoguchi, H. Fujita, and H. Fujiwara Assessment of Vulnerable Plaques Causing Acute Coronary Syndrome Using Integrated Backscatter Intravascular Ultrasound J. Am. Coll. Cardiol., February 21, 2006; 47(4): 734 - 741. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Toutouzas, M. Drakopoulou, J. Mitropoulos, E. Tsiamis, S. Vaina, M. Vavuranakis, V. Markou, E. Bosinakou, and C. Stefanadis Elevated Plaque Temperature in Non-Culprit De Novo Atheromatous Lesions of Patients With Acute Coronary Syndromes J. Am. Coll. Cardiol., January 17, 2006; 47(2): 301 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A. Rodriguez-Granillo, H. M. Garcia-Garcia, E. P. Mc Fadden, M. Valgimigli, J. Aoki, P. de Feyter, and P. W. Serruys In Vivo Intravascular Ultrasound-Derived Thin-Cap Fibroatheroma Detection Using Ultrasound Radiofrequency Data Analysis J. Am. Coll. Cardiol., December 6, 2005; 46(11): 2038 - 2042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Ince, M. Petzsch, H. D. Kleine, H. Schmidt, T. Rehders, T. Korber, C. Schumichen, M. Freund, and C. A. Nienaber Preservation From Left Ventricular Remodeling by Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Use of Granulocyte-Colony-Stimulating Factor (FIRSTLINE-AMI) Circulation, November 15, 2005; 112(20): 3097 - 3106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Ray and C. P. Cannon The Potential Relevance of the Multiple Lipid-Independent (Pleiotropic) Effects of Statins in the Management of Acute Coronary Syndromes J. Am. Coll. Cardiol., October 18, 2005; 46(8): 1425 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Bartnik, K. Malmberg, and L. Ryden Management of patients with type 2 diabetes after acute coronary syndromes Diabetes and Vascular Disease Research, October 1, 2005; 2(3): 144 - 154. [Abstract] [PDF]
|
|
|
|
 |
|
 M.-R. Movahed Failure of Gated Single Photon Emission Computer Tomography Scan to Detect Imminent Acute Plaque Rupture Causing Acute ST-Elevation Myocardial Infarction: Case Report Chest, August 1, 2005; 128(2): 1043 - 1047. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Thanyasiri, D. S. Celermajer, and M. R. Adams Endothelial dysfunction occurs in peripheral circulation patients with acute and stable coronary artery disease Am J Physiol Heart Circ Physiol, August 1, 2005; 289(2): H513 - H517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-K. Hong, G. S. Mintz, C. W. Lee, B.-K. Lee, T.-H. Yang, Y.-H. Kim, J.-M. Song, K.-H. Han, D.-H. Kang, S.-S. Cheong, et al. The Site of Plaque Rupture in Native Coronary Arteries: A Three-Vessel Intravascular Ultrasound Analysis J. Am. Coll. Cardiol., July 19, 2005; 46(2): 261 - 265. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J Figueras, C Pena, and J Soler-Soler Thirty day prognosis of patients with acute pulmonary oedema complicating acute coronary syndromes Heart, July 1, 2005; 91(7): 889 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Libby and P. Theroux Pathophysiology of Coronary Artery Disease Circulation, June 28, 2005; 111(25): 3481 - 3488. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Tanaka, K. Shimada, T. Sano, M. Namba, T. Sakamoto, Y. Nishida, T. Kawarabayashi, D. Fukuda, and J. Yoshikawa Multiple Plaque Rupture and C-Reactive Protein in Acute Myocardial Infarction J. Am. Coll. Cardiol., May 17, 2005; 45(10): 1594 - 1599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Libby Act Local, Act Global: Inflammation and the Multiplicity of "Vulnerable" Coronary Plaques J. Am. Coll. Cardiol., May 17, 2005; 45(10): 1600 - 1602. [Full Text] [PDF]
|
|
|
|
|
|
M. Takano, S. Inami, F. Ishibashi, K. Okamatsu, K. Seimiya, T. Ohba, S. Sakai, and K. Mizuno Angioscopic follow-up study of coronary ruptured plaques in nonculprit lesions J. Am. Coll. Cardiol., March 1, 2005; 45(5): 652 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Ambrose and D. J. D'Agate Plaque rupture and intracoronary thrombus in nonculprit vessels: An eyewitness account J. Am. Coll. Cardiol., March 1, 2005; 45(5): 659 - 660. [Full Text] [PDF]
|
|
|
|
|
|
E. Ferrari, M. Benhamou, P. Cerboni, and B. Marcel Coronary syndromes following aspirin withdrawal: A special risk for late stent thrombosis J. Am. Coll. Cardiol., February 1, 2005; 45(3): 456 - 459. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lerman and A. M. Zeiher Endothelial Function: Cardiac Events Circulation, January 25, 2005; 111(3): 363 - 368. [Full Text] [PDF]
|
|
|
|
|
|
C. Monaco, E. Rossi, D. Milazzo, F. Citterio, F. Ginnetti, G. D'Onofrio, D. Cianflone, F. Crea, L. M. Biasucci, and A. Maseri Persistent systemic inflammation in unstable angina is largely unrelated to the atherothrombotic burden J. Am. Coll. Cardiol., January 18, 2005; 45(2): 238 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Glaser, F. Selzer, D. P. Faxon, W. K. Laskey, H. A. Cohen, J. Slater, K. M. Detre, and R. L. Wilensky Clinical Progression of Incidental, Asymptomatic Lesions Discovered During Culprit Vessel Coronary Intervention Circulation, January 18, 2005; 111(2): 143 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Goto Propagation of Arterial Thrombi: Local and Remote Contributory Factors Arterioscler Thromb Vasc Biol, December 1, 2004; 24(12): 2207 - 2208. [Full Text] [PDF]
|
|
|
|
|
|
B Meier Plaque stabilisation in coronary artery disease: introduction Heart, December 1, 2004; 90(12): 1384 - 1384. [Full Text] [PDF]
|
|
|
|
|
|
J C Spratt and E Camenzind Plaque stabilisation by systemic and local drug administration Heart, December 1, 2004; 90(12): 1392 - 1394. [Full Text] [PDF]
|
|
|
|
|
|
G. Rioufol, M. Gilard, G. Finet, I. Ginon, J. Boschat, and X. Andre-Fouet Evolution of Spontaneous Atherosclerotic Plaque Rupture With Medical Therapy: Long-Term Follow-Up With Intravascular Ultrasound Circulation, November 2, 2004; 110(18): 2875 - 2880. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Schulman Antiplatelet Therapy in Non-ST-Segment Elevation Acute Coronary Syndromes JAMA, October 20, 2004; 292(15): 1875 - 1882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Madjid, A. Zarrabi, S. Litovsky, J. T. Willerson, and W. Casscells Finding Vulnerable Atherosclerotic Plaques: Is It Worth the Effort? Arterioscler Thromb Vasc Biol, October 1, 2004; 24(10): 1775 - 1782. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Zouridakis, P. Avanzas, R. Arroyo-Espliguero, S. Fredericks, and J. C. Kaski Markers of Inflammation and Rapid Coronary Artery Disease Progression in Patients With Stable Angina Pectoris Circulation, September 28, 2004; 110(13): 1747 - 1753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Okazaki, T. Yokoyama, K. Miyauchi, K. Shimada, T. Kurata, H. Sato, and H. Daida Early Statin Treatment in Patients With Acute Coronary Syndrome: Demonstration of the Beneficial Effect on Atherosclerotic Lesions by Serial Volumetric Intravascular Ultrasound Analysis During Half a Year After Coronary Event: The ESTABLISH Study Circulation, August 31, 2004; 110(9): 1061 - 1068. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.-K. Hong, G. S. Mintz, C. W. Lee, Y.-H. Kim, S.-W. Lee, J.-M. Song, K.-H. Han, D.-H. Kang, J.-K. Song, J.-J. Kim, et al. Comparison of Coronary Plaque Rupture Between Stable Angina and Acute Myocardial Infarction: A Three-Vessel Intravascular Ultrasound Study in 235 Patients Circulation, August 24, 2004; 110(8): 928 - 933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P Avanzas, R Arroyo-Espliguero, J Cosin-Sales, G Aldama, C Pizzi, J Quiles, and J C Kaski Markers of inflammation and multiple complex stenoses (pancoronary plaque vulnerability) in patients with non-ST segment elevation acute coronary syndromes Heart, August 1, 2004; 90(8): 847 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lombardo, L. M. Biasucci, G. A. Lanza, S. Coli, P. Silvestri, D. Cianflone, G. Liuzzo, F. Burzotta, F. Crea, and A. Maseri Inflammation as a Possible Link Between Coronary and Carotid Plaque Instability Circulation, June 29, 2004; 109(25): 3158 - 3163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. C. Luft Cardiac Angiotensin Is Upregulated in the Hearts of Unstable Angina Patients Circ. Res., June 25, 2004; 94(12): 1530 - 1532. [Full Text] [PDF]
|
|
|
|
|
|
G. G. Neri Serneri, M. Boddi, P. A. Modesti, M. Coppo, I. Cecioni, T. Toscano, M. L. Papa, M. Bandinelli, G. F. Lisi, and M. Chiavarelli Cardiac Angiotensin II Participates in Coronary Microvessel Inflammation of Unstable Angina and Strengthens the Immunomediated Component Circ. Res., June 25, 2004; 94(12): 1630 - 1637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Schaar, E. Regar, F. Mastik, E. P. McFadden, F. Saia, C. Disco, C. L. de Korte, P. J. de Feyter, A. F.W. van der Steen, and P. W. Serruys Incidence of High-Strain Patterns in Human Coronary Arteries: Assessment With Three-Dimensional Intravascular Palpography and Correlation With Clinical Presentation Circulation, June 8, 2004; 109(22): 2716 - 2719. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Schaar, J. E Muller, E. Falk, R. Virmani, V. Fuster, P. W Serruys, A. Colombo, C. Stefanadis, S Ward Casscells, P. R Moreno, et al. Terminology for high-risk and vulnerable coronary artery plaques Eur. Heart J., June 2, 2004; 25(12): 1077 - 1082. [Abstract] [Full Text] [PDF]
|
|