Circulation. 2002;106:2781-2786
Published online before print November 4, 2002, doi: 10.1161/01.CIR.0000039526.42991.93
Published online before print November 4, 2002, doi: 10.1161/01.CIR.0000039526.42991.93
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(Circulation. 2002;106:2781.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Human Endothelial Progenitor Cells From Type II Diabetics Exhibit Impaired Proliferation, Adhesion, and Incorporation Into Vascular Structures
From the Laboratory of Microvascular Research and Vascular Tissue Engineering, Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York, NY (O.M.T., R.D.G., J.M.C., J.P.L., G.C.G.); the Department of Cardiology, Pneumology, and Vascular Medicine, Heinrich-Heine University, Duesseldorf, Germany (C.K.); and the Department of Surgery, New York University Medical Center, New York, NY (P.J.G., G.R.J.).
Correspondence to Geoffrey C. Gurtner, MD, New York University Medical Center, TH-169, 550 First Ave, New York, NY 10016. E-mail geoffrey.gurtner{at}med.nyu.edu
Background— The recent discovery of circulating endothelial progenitor cells (EPCs) has altered our understanding of new blood vessel growth such as occurs during collateral formation. Because diabetic complications occur in conditions in which EPC contributions have been demonstrated, EPC dysfunction may be important in their pathophysiology.
Methods and Results— EPCs were isolated from human type II diabetics (n=20) and age-matched control subjects (n=20). Proliferation of diabetic EPCs relative to control subjects was decreased by 48% (P<0.01) and inversely correlated with patient levels of hemoglobin A1C (P<0.05). Diabetic EPCs had normal adhesion to fibronectin, collagen, and quiescent endothelial cells but a decreased adherence to human umbilical vein endothelial cells activated by tumor necrosis factor-
(TNF-) (P<0.05). In a Matrigel assay, diabetic EPCs were 2.5 times less likely to participate in tubule formation compared with controls (P<0.05).
Conclusions— These findings suggest that type II diabetes may alter EPC biology in processes critical for new blood vessel growth and may identify a population at high risk for morbidity and mortality after vascular occlusive events.
Key Words: collateral circulation • diabetes mellitus • angiogenesis
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T.-S. Li, M. Takahashi, R. Suzuki, T. Kobayashi, H. Ito, A. Mikamo, and K. Hamano Pravastatin Improves Remodeling and Cardiac Function After Myocardial Infarction by an Antiinflammatory Mechanism Rather than by the Induction of Angiogenesis Ann. Thorac. Surg., June 1, 2006; 81(6): 2217 - 2225. [Abstract] [Full Text] [PDF]
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F. X. Ma, B. Zhou, Z. Chen, Q. Ren, S. H. Lu, T. Sawamura, and Z. C. Han Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase J. Lipid Res., June 1, 2006; 47(6): 1227 - 1237. [Abstract] [Full Text] [PDF]
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J. Chen and M. S. Goligorsky Premature senescence of endothelial cells: Methusaleh's dilemma Am J Physiol Heart Circ Physiol, May 1, 2006; 290(5): H1729 - H1739. [Abstract] [Full Text] [PDF]
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M. Sata Role of Circulating Vascular Progenitors in Angiogenesis, Vascular Healing, and Pulmonary Hypertension: Lessons From Animal Models Arterioscler. Thromb. Vasc. Biol., May 1, 2006; 26(5): 1008 - 1014. [Abstract] [Full Text] [PDF]
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H. Chon, M. C. Verhaar, H. A. Koomans, J. A. Joles, and B. Braam Role of Circulating Karyocytes in the Initiation and Progression of Atherosclerosis Hypertension, May 1, 2006; 47(5): 803 - 810. [Abstract] [Full Text] [PDF]
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O. Awad, E. I. Dedkov, C. Jiao, S. Bloomer, R. J. Tomanek, and G. C. Schatteman Differential Healing Activities of CD34+ and CD14+ Endothelial Cell Progenitors Arterioscler. Thromb. Vasc. Biol., April 1, 2006; 26(4): 758 - 764. [Abstract] [Full Text] [PDF]
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D. A. Klibansky, A. Chin, I. J. Duignan, and J. M. Edelberg Synergistic targeting with bone marrow-derived cells and PDGF improves diabetic vascular function Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1387 - H1392. [Abstract] [Full Text] [PDF]
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T.-S. Li, A. Furutani, M. Takahashi, M. Ohshima, S.-L. Qin, T. Kobayashi, H. Ito, and K. Hamano Impaired potency of bone marrow mononuclear cells for inducing therapeutic angiogenesis in obese diabetic rats Am J Physiol Heart Circ Physiol, April 1, 2006; 290(4): H1362 - H1369. [Abstract] [Full Text] [PDF]
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T. Thum, D. Fraccarollo, P. Galuppo, D. Tsikas, S. Frantz, G. Ertl, and J. Bauersachs Bone marrow molecular alterations after myocardial infarction: Impact on endothelial progenitor cells Cardiovasc Res, April 1, 2006; 70(1): 50 - 60. [Abstract] [Full Text] [PDF]
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M. Ii, H. Takenaka, J. Asai, K. Ibusuki, Y. Mizukami, K. Maruyama, Y.-s. Yoon, A. Wecker, C. Luedemann, E. Eaton, et al. Endothelial Progenitor Thrombospondin-1 Mediates Diabetes-Induced Delay in Reendothelialization Following Arterial Injury Circ. Res., March 17, 2006; 98(5): 697 - 704. [Abstract] [Full Text] [PDF]
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J. Leor, E. Guetta, M. S. Feinberg, H. Galski, I. Bar, R. Holbova, L. Miller, P. Zarin, D. Castel, I. M. Barbash, et al. Human Umbilical Cord Blood-Derived CD133+ Cells Enhance Function and Repair of the Infarcted Myocardium Stem Cells, March 1, 2006; 24(3): 772 - 780. [Abstract] [Full Text] [PDF]
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G. C. Schatteman and N. Ma Old Bone Marrow Cells Inhibit Skin Wound Vascularization Stem Cells, March 1, 2006; 24(3): 717 - 721. [Abstract] [Full Text] [PDF]
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A. A. Quyyumi Women and Ischemic Heart Disease: Pathophysiologic Implications From the Women's Ischemia Syndrome Evaluation (WISE) Study and Future Research Steps J. Am. Coll. Cardiol., February 7, 2006; 47(3_Suppl_S): S66 - S71. [Abstract] [Full Text] [PDF]
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H. Langer, A. E. May, K. Daub, U. Heinzmann, P. Lang, M. Schumm, D. Vestweber, S. Massberg, T. Schonberger, I. Pfisterer, et al. Adherent Platelets Recruit and Induce Differentiation of Murine Embryonic Endothelial Progenitor Cells to Mature Endothelial Cells In Vitro Circ. Res., February 3, 2006; 98(2): e2 - e10. [Abstract] [Full Text] [PDF]
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G. Galasso, S. Schiekofer, K. Sato, R. Shibata, D. E. Handy, N. Ouchi, J. A. Leopold, J. Loscalzo, and K. Walsh Impaired Angiogenesis in Glutathione Peroxidase-1-Deficient Mice Is Associated With Endothelial Progenitor Cell Dysfunction Circ. Res., February 3, 2006; 98(2): 254 - 261. [Abstract] [Full Text] [PDF]
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T. Raupach, K. Schafer, S. Konstantinides, and S. Andreas Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm Eur. Heart J., February 2, 2006; 27(4): 386 - 392. [Abstract] [Full Text] [PDF]
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N. Werner and G. Nickenig Influence of Cardiovascular Risk Factors on Endothelial Progenitor Cells: Limitations for Therapy? Arterioscler. Thromb. Vasc. Biol., February 1, 2006; 26(2): 257 - 266. [Abstract] [Full Text] [PDF]
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J.-S. Silvestre and B. I. Levy Molecular Basis of Angiopathy in Diabetes Mellitus Circ. Res., January 6, 2006; 98(1): 4 - 6. [Full Text] [PDF]
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D. H. Walter, J. Haendeler, J. Reinhold, U. Rochwalsky, F. Seeger, J. Honold, J. Hoffmann, C. Urbich, R. Lehmann, F. Arenzana-Seisdesdos, et al. Impaired CXCR4 Signaling Contributes to the Reduced Neovascularization Capacity of Endothelial Progenitor Cells From Patients With Coronary Artery Disease Circ. Res., November 25, 2005; 97(11): 1142 - 1151. [Abstract] [Full Text] [PDF]
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T. Thum, D. Tsikas, S. Stein, M. Schultheiss, M. Eigenthaler, S. D. Anker, P. A. Poole-Wilson, G. Ertl, and J. Bauersachs Suppression of Endothelial Progenitor Cells in Human Coronary Artery Disease by the Endogenous Nitric Oxide Synthase Inhibitor Asymmetric Dimethylarginine J. Am. Coll. Cardiol., November 1, 2005; 46(9): 1693 - 1701. [Abstract] [Full Text] [PDF]
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J. George, E. Goldstein, A. Abashidze, D. Wexler, S. Hamed, H. Shmilovich, V. Deutsch, H. Miller, G. Keren, and A. Roth Erythropoietin promotes endothelial progenitor cell proliferative and adhesive properties in a PI 3-kinase-dependent manner Cardiovasc Res, November 1, 2005; 68(2): 299 - 306. [Abstract] [Full Text] [PDF]
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M. Simons Angiogenesis, Arteriogenesis, and Diabetes: Paradigm Reassessed? J. Am. Coll. Cardiol., September 6, 2005; 46(5): 835 - 837. [Full Text] [PDF]
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P. Huang, S. Li, M. Han, Z. Xiao, R. Yang, and Z. C. Han Autologous Transplantation of Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood Mononuclear Cells Improves Critical Limb Ischemia in Diabetes Diabetes Care, September 1, 2005; 28(9): 2155 - 2160. [Abstract] [Full Text] [PDF]
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V. J. Dzau, M. Gnecchi, A. S. Pachori, F. Morello, and L. G. Melo Therapeutic Potential of Endothelial Progenitor Cells in Cardiovascular Diseases Hypertension, July 1, 2005; 46(1): 7 - 18. [Abstract] [Full Text] [PDF]
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K. Naruse, Y. Hamada, E. Nakashima, K. Kato, R. Mizubayashi, H. Kamiya, Y. Yuzawa, S. Matsuo, T. Murohara, T. Matsubara, et al. Therapeutic Neovascularization Using Cord Blood-Derived Endothelial Progenitor Cells for Diabetic Neuropathy Diabetes, June 1, 2005; 54(6): 1823 - 1828. [Abstract] [Full Text] [PDF]
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C. Heiss, S. Keymel, U. Niesler, J. Ziemann, M. Kelm, and C. Kalka Impaired Progenitor Cell Activity in Age-Related Endothelial Dysfunction J. Am. Coll. Cardiol., May 3, 2005; 45(9): 1441 - 1448. [Abstract] [Full Text] [PDF]
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