Circulation. 2002;106:2322-2327
Published online before print October 7, 2002, doi: 10.1161/01.CIR.0000036368.63317.1C
Published online before print October 7, 2002, doi: 10.1161/01.CIR.0000036368.63317.1C
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
(Circulation. 2002;106:2322.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Reproducibility of Chronic Infarct Size Measurement by Contrast-Enhanced Magnetic Resonance Imaging
From the Northwestern University Medical School Feinberg Cardiovascular Research Institute, Chicago, Ill.
Correspondence to Robert M. Judd, PhD, Duke Cardiovascular Magnetic Resonance Center, Duke University Health System, PO Box 3934, Durham, NC 27710. E-mail Robert.Judd{at}dcmrc.mc.duke.edu
Background— The reproducibility of contrast-enhanced MRI has not been established. We compared MRI reproducibility for infarct size determination with that of 99mTc-sestamibi (MIBI) single photon emission computed tomography (SPECT).
Methods and Results— Patients with chronic myocardial infarction defined by enzymes (peak creatine kinase-MB 173±119 U/L) were scanned twice by MRI (MRI I and MRI II, n=20) and twice by SPECT (SPECT I and SPECT II, n=15) on the same day. The MRI contrast agent was injected during MRI I but not MRI II to test the effect of imaging time after contrast. Resting Tc-MIBI SPECT images were acquired and infarct size was determined with commercial software. Infarct size in patients scanned by MRI and SPECT was 14±6% of left ventricular mass (%LV) by MRI (range 4%LV to 27%LV) and 14±7%LV by SPECT (range 4%LV to 26%LV). MRI I and II scans were performed 10±2 and 27±3 minutes after contrast, respectively. For MRI, the difference in infarct size between scans I and II (bias) was -0.1%LV, and the coefficient of repeatability was ±2.4%LV. For SPECT, bias was -1.3%LV, and the coefficient of repeatability was ±4.0%LV. Within individual patients, no systematic differences in infarct size were detected when the 2 MRI scans were compared, the 2 SPECT scans were compared, or MRI was compared to SPECT.
Conclusion— The size of healed infarcts measured by contrast-enhanced MRI does not change between 10 and 30 minutes after contrast. The clinical reproducibility of contrast-enhanced MRI for infarct size determination compares favorably with that of routine clinical SPECT.
Key Words: reproducibility • contrast media • magnetic resonance imaging • scintigraphy
This article has been cited by other articles:
 |
|
 |
|
  H. Vogelsberg, H. Mahrholdt, C. C. Deluigi, A. Yilmaz, E. M. Kispert, S. Greulich, K. Klingel, R. Kandolf, and U. Sechtem Cardiovascular magnetic resonance in clinically suspected cardiac amyloidosis: noninvasive imaging compared to endomyocardial biopsy. J. Am. Coll. Cardiol., March 11, 2008; 51(10): 1022 - 1030. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. S.H. Cheng, J. B. Selvanayagam, M. Jerosch-Herold, W. J. van Gaal, T. D. Karamitsos, S. Neubauer, and A. P. Banning Percutaneous Treatment of Chronic Total Coronary Occlusions Improves Regional Hyperemic Myocardial Blood Flow and Contractility: Insights From Quantitative Cardiovascular Magnetic Resonance Imaging J. Am. Coll. Cardiol. Intv., February 1, 2008; 1(1): 44 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. B. Selvanayagam, A. S.H. Cheng, M. Jerosch-Herold, K. Rahimi, I. Porto, W. van Gaal, K. M. Channon, S. Neubauer, and A. P. Banning Effect of Distal Embolization on Myocardial Perfusion Reserve After Percutaneous Coronary Intervention: A Quantitative Magnetic Resonance Perfusion Study Circulation, September 25, 2007; 116(13): 1458 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. N. Martin, B. A. Groenning, H. M. Murray, T. Steedman, J. E. Foster, A. T. Elliot, H. J. Dargie, R. H. Selvester, O. Pahlm, and G. S. Wagner ST-Segment Deviation Analysis of the Admission 12-Lead Electrocardiogram as an Aid to Early Diagnosis of Acute Myocardial Infarction With a Cardiac Magnetic Resonance Imaging Gold Standard J. Am. Coll. Cardiol., September 11, 2007; 50(11): 1021 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. Petersen, M. Jerosch-Herold, L. E. Hudsmith, M. D. Robson, J. M. Francis, H. A. Doll, J. B. Selvanayagam, S. Neubauer, and H. Watkins Evidence for Microvascular Dysfunction in Hypertrophic Cardiomyopathy: New Insights From Multiparametric Magnetic Resonance Imaging Circulation, May 8, 2007; 115(18): 2418 - 2425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Sievers, M. D. Elliott, L. M. Hurwitz, T. S.E. Albert, I. Klem, W. G. Rehwald, M. A. Parker, R. M. Judd, and R. J. Kim Rapid Detection of Myocardial Infarction by Subsecond, Free-Breathing Delayed Contrast-Enhancement Cardiovascular Magnetic Resonance Circulation, January 16, 2007; 115(2): 236 - 244. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mahrholdt, A. Wagner, C. C. Deluigi, E. Kispert, S. Hager, G. Meinhardt, H. Vogelsberg, P. Fritz, J. Dippon, C. -T. Bock, et al. Presentation, Patterns of Myocardial Damage, and Clinical Course of Viral Myocarditis Circulation, October 10, 2006; 114(15): 1581 - 1590. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. T. Yan, A. J. Shayne, K. A. Brown, S. N. Gupta, C. W. Chan, T. M. Luu, M. F. Di Carli, H. G. Reynolds, W. G. Stevenson, and R. Y. Kwong Characterization of the Peri-Infarct Zone by Contrast-Enhanced Cardiac Magnetic Resonance Imaging Is a Powerful Predictor of Post-Myocardial Infarction Mortality Circulation, July 4, 2006; 114(1): 32 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Setser, J. K. Kim, Y. C. Chung, K. Chen, A. E. Stillman, R. Loeffler, O. P. Simonetti, J. A. Weaver, M. L. Lieber, and R. D. White Cine Delayed-Enhancement MR Imaging of the Heart: Initial Experience Radiology, June 1, 2006; 239(3): 856 - 862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Wagner, H. Mahrholdt, L. Thomson, S. Hager, G. Meinhardt, W. Rehwald, M. Parker, D. Shah, U. Sechtem, R. J. Kim, et al. Effects of Time, Dose, and Inversion Time for Acute Myocardial Infarct Size Measurements Based on Magnetic Resonance Imaging-Delayed Contrast Enhancement J. Am. Coll. Cardiol., May 16, 2006; 47(10): 2027 - 2033. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. F. Christian Positively Magnetic North J. Am. Coll. Cardiol., April 18, 2006; 47(8): 1646 - 1648. [Full Text] [PDF]
|
|
|
|
|
|
H. Thiele, M. J.E. Kappl, S. Conradi, J. Niebauer, R. Hambrecht, and G. Schuler Reproducibility of Chronic and Acute Infarct Size Measurement by Delayed Enhancement-Magnetic Resonance Imaging J. Am. Coll. Cardiol., April 18, 2006; 47(8): 1641 - 1645. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. P. Meyer, K. C. Wollert, J. Lotz, J. Steffens, P. Lippolt, S. Fichtner, H. Hecker, A. Schaefer, L. Arseniev, B. Hertenstein, et al. Intracoronary Bone Marrow Cell Transfer After Myocardial Infarction: Eighteen Months' Follow-Up Data From the Randomized, Controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) Trial Circulation, March 14, 2006; 113(10): 1287 - 1294. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Baks, R.-J. van Geuns, E. Biagini, P. Wielopolski, N. R. Mollet, F. Cademartiri, W. J. van der Giessen, G. P. Krestin, P. W. Serruys, D. J. Duncker, et al. Effects of Primary Angioplasty for Acute Myocardial Infarction on Early and Late Infarct Size and Left Ventricular Wall Characteristics J. Am. Coll. Cardiol., January 3, 2006; 47(1): 40 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Baks, R.-J. van Geuns, E. Biagini, P. Wielopolski, N. R. Mollet, F. Cademartiri, W. J. van der Giessen, G. P. Krestin, P. W. Serruys, D. J. Duncker, et al. Effects of Primary Angioplasty for Acute Myocardial Infarction on Early and Late Infarct Size and Left Ventricular Wall Characteristics J. Am. Coll. Cardiol., December 13, 2005; (2005) j.jacc.2005.09.008v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Khorsand, S. Graf, H. Eidherr, W. Wadsak, K. Kletter, H. Sochor, E. Schuster, and G. Porenta Gated Cardiac 13N-NH3 PET for Assessment of Left Ventricular Volumes, Mass, and Ejection Fraction: Comparison with Electrocardiography-Gated 18F-FDG PET J. Nucl. Med., December 1, 2005; 46(12): 2009 - 2013. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ishida, H. Sakuma, N. Kato, N. Ishida, K. Kitagawa, T. Shimono, I. Yada, and K. Takeda Contrast-enhanced MR Imaging for Evaluation of Coronary Artery Disease before Elective Repair of Aortic Aneurysm Radiology, November 1, 2005; 237(2): 458 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Thiele, L. Engelmann, K. Elsner, M. J. Kappl, W.-H. Storch, K. Rahimi, A. Hartmann, D. Pfeiffer, G. D. Kneissl, D. Schneider, et al. Comparison of pre-hospital combination-fibrinolysis plus conventional care with pre-hospital combination-fibrinolysis plus facilitated percutaneous coronary intervention in acute myocardial infarction Eur. Heart J., October 1, 2005; 26(19): 1956 - 1963. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Zhang, A. K.Y. Chan, C.-M. Yu, G. W.K. Yip, J. W.H. Fung, W. W.M. Lam, N. M.C. So, M. Wang, E. B. Wu, J. T. Wong, et al. Strain Rate Imaging Differentiates Transmural From Non-Transmural Myocardial Infarction: A Validation Study Using Delayed-Enhancement Magnetic Resonance Imaging J. Am. Coll. Cardiol., September 6, 2005; 46(5): 864 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Bulow, C Klein, I Kuehn, R Hollweck, S G Nekolla, K Schreiber, F Haas, J Bohm, B Schnackenburg, R Lange, et al. Cardiac magnetic resonance imaging: long term reproducibility of the late enhancement signal in patients with chronic coronary artery disease Heart, September 1, 2005; 91(9): 1158 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Schlosser, P. Hunold, C. U. Herborn, H. Lehmkuhl, A. Lind, S. Massing, and J. Barkhausen Myocardial Infarct: Depiction with Contrast-enhanced MR Imaging--Comparison of Gadopentetate and Gadobenate Radiology, September 1, 2005; 236(3): 1041 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Ashikaga, S. R. Mickelsen, D. B. Ennis, I. Rodriguez, P. Kellman, H. Wen, and E. R. McVeigh Electromechanical analysis of infarct border zone in chronic myocardial infarction Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1099 - H1105. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J. Slomka, D. Fieno, L. Thomson, J. D. Friedman, S. W. Hayes, G. Germano, and D. S. Berman Automatic Detection and Size Quantification of Infarcts by Myocardial Perfusion SPECT: Clinical Validation by Delayed-Enhancement MRI J. Nucl. Med., May 1, 2005; 46(5): 728 - 735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Amado, B. L. Gerber, S. N. Gupta, D. W. Rettmann, G. Szarf, R. Schock, K. Nasir, D. L. Kraitchman, and J. A.C. Lima Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model J. Am. Coll. Cardiol., December 21, 2004; 44(12): 2383 - 2389. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Pennell, U. P. Sechtem, C. B. Higgins, W. J. Manning, G. M. Pohost, F. E. Rademakers, A. C. van Rossum, L. J. Shaw, and E. K. Yucel Clinical indications for cardiovascular magnetic resonance (CMR): Consensus Panel report Eur. Heart J., November 1, 2004; 25(21): 1940 - 1965. [Full Text] [PDF]
|
|
|
|
|
|
R. J. Gibbons, U. S. Valeti, P. A. Araoz, and A. S. Jaffe The quantification of infarct size J. Am. Coll. Cardiol., October 19, 2004; 44(8): 1533 - 1542. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Selvanayagam, A. Kardos, J. M. Francis, F. Wiesmann, S. E. Petersen, D. P. Taggart, and S. Neubauer Value of Delayed-Enhancement Cardiovascular Magnetic Resonance Imaging in Predicting Myocardial Viability After Surgical Revascularization Circulation, September 21, 2004; 110(12): 1535 - 1541. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Writing Committee Members, E. M. Antman, D. T. Anbe, P. W. Armstrong, E. R. Bates, L. A. Green, M. Hand, J. S. Hochman, H. M. Krumholz, F. G. Kushner, et al. ACC/AHA guidelines for the management of patients with ST-Elevation myocardial infarction--executive summary: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (writing committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction) J. Am. Coll. Cardiol., August 4, 2004; 44(3): 671 - 719. [Full Text] [PDF]
|
|
|
|
|
|
E. M. Antman, D. T. Anbe, P. W. Armstrong, E. R. Bates, L. A. Green, M. Hand, J. S. Hochman, H. M. Krumholz, F. G. Kushner, G. A. Lamas, et al. ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction) Circulation, August 3, 2004; 110(5): 588 - 636. [Full Text] [PDF]
|
|
|
|
 |
|
 R. Bolli, L. Becker, G. Gross, R. Mentzer Jr, D. Balshaw, and D. A. Lathrop Myocardial Protection at a Crossroads: The Need for Translation Into Clinical Therapy Circ. Res., July 23, 2004; 95(2): 125 - 134. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. K. Lund, A. Stork, M. Saeed, M. P. Bansmann, J. H. Gerken, V. Muller, J. Mester, C. B. Higgins, G. Adam, and T. Meinertz Acute Myocardial Infarction: Evaluation with First-Pass Enhancement and Delayed Enhancement MR Imaging Compared with 201Tl SPECT Imaging Radiology, July 1, 2004; 232(1): 49 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Abdel-Aty, A. Zagrosek, J. Schulz-Menger, A. J. Taylor, D. Messroghli, A. Kumar, M. Gross, R. Dietz, and M. G. Friedrich Delayed Enhancement and T2-Weighted Cardiovascular Magnetic Resonance Imaging Differentiate Acute From Chronic Myocardial Infarction Circulation, May 25, 2004; 109(20): 2411 - 2416. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Wellnhofer, A. Olariu, C. Klein, M. Grafe, A. Wahl, E. Fleck, and E. Nagel Magnetic Resonance Low-Dose Dobutamine Test Is Superior to Scar Quantification for the Prediction of Functional Recovery Circulation, May 11, 2004; 109(18): 2172 - 2174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.R. Underwood, J. J Bax, J. v. Dahl, M. Y Henein, A. C van Rossum, E. R Schwarz, J.-L. Vanoverschelde, E. E.v. d. Wall, and W. Wijns Imaging techniques for the assessment of myocardial hibernation: Report of a Study Group of the European Society of Cardiology Eur. Heart J., May 2, 2004; 25(10): 815 - 836. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shan, G. Constantine, M. Sivananthan, and S. D. Flamm Role of Cardiac Magnetic Resonance Imaging in the Assessment of Myocardial Viability Circulation, March 23, 2004; 109(11): 1328 - 1334. [Full Text] [PDF]
|
|
|
|
|
|
H. Mahrholdt, C. Goedecke, A. Wagner, G. Meinhardt, A. Athanasiadis, H. Vogelsberg, P. Fritz, K. Klingel, R. Kandolf, and U. Sechtem Cardiovascular Magnetic Resonance Assessment of Human Myocarditis: A Comparison to Histology and Molecular Pathology Circulation, March 16, 2004; 109(10): 1250 - 1258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. P. Kuhl, T. S. Papavasiliu, A. M. Beek, M. B. M. Hofman, N. S. Heusen, and A. C. van Rossum Myocardial Viability: Rapid Assessment with Delayed Contrast-enhanced MR Imaging with Three-dimensional Inversion-Recovery Prepared Pulse Sequence Radiology, February 1, 2004; 230(2): 576 - 582. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. B. Selvanayagam, S. E. Petersen, J. M. Francis, M. D. Robson, A. Kardos, S. Neubauer, and D. P. Taggart Effects of Off-Pump Versus On-Pump Coronary Surgery on Reversible and Irreversible Myocardial Injury: A Randomized Trial Using Cardiovascular Magnetic Resonance Imaging and Biochemical Markers Circulation, January 27, 2004; 109(3): 345 - 350. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Wu and J. A.C. Lima Noninvasive Imaging of Myocardial Viability: Current Techniques and Future Developments Circ. Res., December 12, 2003; 93(12): 1146 - 1158. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. J. Kim and R. M. Judd Gadolinium-Enhancedmagnetic resonance imagingin hypertrophic cardiomyopathy: In vivo imaging of the pathologic substrate for premature cardiac death? J. Am. Coll. Cardiol., May 7, 2003; 41(9): 1568 - 1572. [Full Text] [PDF]
|
|