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(Circulation. 2002;106:2188.)
© 2002 American Heart Association, Inc.

Brief Rapid Communications

Involvement of Endogenous Endothelin-1 in Exercise-Induced Redistribution of Tissue Blood Flow

An Endothelin Receptor Antagonist Reduces the Redistribution

Seiji Maeda, PhD; Takashi Miyauchi, MD, PhD; Motoyuki Iemitsu, MS; Takumi Tanabe, MS; Yoko Irukayama-Tomobe, PhD; Katsutoshi Goto, PhD; Iwao Yamaguchi, MD, PhD; Mitsuo Matsuda, MD, PhD

From the Department of Sports Medicine, Institute of Health and Sport Sciences (S.M., T.T., Y.I.-T., M.M.), Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine (T.M., M.I., I.Y.), and Department of Pharmacology (K.G.), University of Tsukuba, Tsukuba, Ibaraki, Japan.

Correspondence to Mitsuo Matsuda, MD, PhD, Department of Sports Medicine, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8574, Japan. E-mail m-matsuda{at}taiiku.tsukuba.ac.jp

Background— Endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor peptide. Exercise results in a significant redistribution of tissue blood flow, which greatly increases blood flow in active muscles but decreases it in the splanchnic circulation. We reported that exercise causes an increase of ET-1 production in the internal organ and then hypothesized that ET-1 participates in the exercise-induced redistribution of tissue blood flow. We investigated the effects of acute endothelin-A (ETA)-receptor blockade on regional tissue blood flow during exercise in rats.

Methods and Results— Regional blood flow in the kidney, spleen, stomach, intestine, and muscles was measured using the microsphere technique before and during treadmill running of 30 minutes duration at 30 m/min after pretreatment with either an ETA-receptor antagonist (TA-0201; 0.5 mg/kg) or vehicle in rats. Blood flow in the kidney, spleen, stomach, and intestine was decreased by exercise, but the magnitude of the decrease after pretreatment with TA-0201 was significantly smaller than that after pretreatment with vehicle. Furthermore, the increase in blood flow to active muscles induced by exercise was significantly smaller in rats pretreated with TA-0201 than those pretreated with vehicle.

Conclusions— The present study revealed that ET-1-mediated vasoconstriction participates in the decrease of blood flow in the internal organs of rats during exercise, and therefore, that these actions of endogenous ET-1 partly contribute to the increase of blood flow in active muscles during exercise. The data suggest that endogenous ET-1 participates in the exercise-induced redistribution of tissue blood flow.

Key Words: endothelin • exercise • blood flow • receptors

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