Circulation. 2002;105:1135-1143
doi: 10.1161/hc0902.104353
doi: 10.1161/hc0902.104353
(Circulation. 2002;105:1135.)
© 2002 American Heart Association, Inc.
Clinical Cardiology: New Frontiers |
Inflammation and Atherosclerosis
From the Leducq Center for Cardiovascular Research (P.L., P.M.R.) and Center for Cardiovascular Disease Prevention (P.M.R.), Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass, and Department of Cardiovascular Disease (A.M.), University Vita-Salute San Raffaele, Milan, Italy.
Correspondence to Peter Libby, MD, Brigham and Women’s Hospital, 221 Longwood Ave, LMRC 307, Boston, MA 02115. E-mail plibby{at}rics.bwh.harvard.edu
Atherosclerosis, formerly considered a bland lipid storage disease, actually involves an ongoing inflammatory response. Recent advances in basic science have established a fundamental role for inflammation in mediating all stages of this disease from initiation through progression and, ultimately, the thrombotic complications of atherosclerosis. These new findings provide important links between risk factors and the mechanisms of atherogenesis. Clinical studies have shown that this emerging biology of inflammation in atherosclerosis applies directly to human patients. Elevation in markers of inflammation predicts outcomes of patients with acute coronary syndromes, independently of myocardial damage. In addition, low-grade chronic inflammation, as indicated by levels of the inflammatory marker C-reactive protein, prospectively defines risk of atherosclerotic complications, thus adding to prognostic information provided by traditional risk factors. Moreover, certain treatments that reduce coronary risk also limit inflammation. In the case of lipid lowering with statins, this anti-inflammatory effect does not appear to correlate with reduction in low-density lipoprotein levels. These new insights into inflammation in atherosclerosis not only increase our understanding of this disease, but also have practical clinical applications in risk stratification and targeting of therapy for this scourge of growing worldwide importance.
Key Words: endothelium • inflammation • atherosclerosis • proteins
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B. Guldiken, S. Guldiken, B. Turgut, N. Turgut, M. Demir, Y. Celik, E. Arikan, and A. Tugrul The Roles of Oxidized Low-Density Lipoprotein and Interleukin-6 Levels in Acute Atherothrombotic and Lacunar Ischemic Stroke Angiology, May 1, 2008; 59(2): 224 - 229. [Abstract] [PDF]
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J. F. Arenillas, J. Alvarez-Sabin, C. A. Molina, P. Chacon, I. Fernandez-Cadenas, M. Ribo, P. Delgado, M. Rubiera, A. Penalba, A. Rovira, et al. Progression of Symptomatic Intracranial Large Artery Atherosclerosis Is Associated With a Proinflammatory State and Impaired Fibrinolysis Stroke, May 1, 2008; 39(5): 1456 - 1463. [Abstract] [Full Text] [PDF]
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D. A. Nation, J. A. Gonzales, A. J. Mendez, J. Zaias, A. Szeto, L. G. Brooks, J. Paredes, A. D'Angola, N. Schneiderman, and P. M. McCabe The Effect of Social Environment on Markers of Vascular Oxidative Stress and Inflammation in the Watanabe Heritable Hyperlipidemic Rabbit Psychosom Med, April 1, 2008; 70(3): 269 - 275. [Abstract] [Full Text] [PDF]
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G. D. Barish, A. R. Atkins, M. Downes, P. Olson, L.-W. Chong, M. Nelson, Y. Zou, H. Hwang, H. Kang, L. Curtiss, et al. PPAR{delta} regulates multiple proinflammatory pathways to suppress atherosclerosis PNAS, March 18, 2008; 105(11): 4271 - 4276. [Abstract] [Full Text] [PDF]
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U. J. F. Tietge, N. Nijstad, R. Havinga, J. F. W. Baller, F. H. van der Sluijs, V. W. Bloks, T. Gautier, and F. Kuipers Secretory phospholipase A2 increases SR-BI-mediated selective uptake from HDL but not biliary cholesterol secretion J. Lipid Res., March 1, 2008; 49(3): 563 - 571. [Abstract] [Full Text] [PDF]
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A. E. Caballero, K. Bousquet-Santos, L. Robles-Osorio, V. Montagnani, G. Soodini, S. Porramatikul, O. Hamdy, A. C.L. Nobrega, and E. S. Horton Overweight Latino Children and Adolescents Have Marked Endothelial Dysfunction and Subclinical Vascular Inflammation in Association With Excess Body Fat and Insulin Resistance Diabetes Care, March 1, 2008; 31(3): 576 - 582. [Abstract] [Full Text] [PDF]
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T. Omland, T. Ueland, A. M. Jansson, A. Persson, T. Karlsson, C. Smith, J. Herlitz, P. Aukrust, M. Hartford, and K. Caidahl Circulating osteoprotegerin levels and long-term prognosis in patients with acute coronary syndromes. J. Am. Coll. Cardiol., February 12, 2008; 51(6): 627 - 633. [Abstract] [Full Text] [PDF]
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E. N. Glaros, W. S. Kim, C. M. Quinn, W. Jessup, K.-A. Rye, and B. Garner Myriocin slows the progression of established atherosclerotic lesions in apolipoprotein E gene knockout mice J. Lipid Res., February 1, 2008; 49(2): 324 - 331. [Abstract] [Full Text] [PDF]
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