Published online before print February 11, 2002, doi: 10.1161/hc0902.104676
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(Circulation. 2002;105:1044.)
© 2002 American Heart Association, Inc.
Clinical Investigation and Reports |
Patients With Glanzmann Thrombasthenia Lacking Platelet Glycoprotein 
IIbß3 (GPIIb/IIIa) and vß3 Receptors Are Not Protected From Atherosclerosis
From the Institute of Thrombosis and Hemostasis (O.S., U.S.), Laboratory of Vascular Surgery (I.R., R.V.), and the Branco and Eva Weiss Institute of Lipid and Atherosclerosis Research (D.H.), Sheba Medical Center, Tel-Hashomer, Israel; the Epidemiology Ultrasound Research Laboratory, Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pa (K.S., K.S.T.); and the Department of Medicine, Mount Sinai Hospital, New York, NY (B.C.).
Correspondence to Uri Seligsohn, MD, Institute of Thrombosis and Hemostasis, Sheba Medical Center, Tel Hashomer, Israel 52621. E-mail seligson{at}sheba.health.gov.il
Background— Platelets have been suggested to play a role in the early development of atherosclerosis. As one test of this hypothesis, we assessed whether patients with Glanzmann thrombasthenia who lack platelet glycoprotein 
IIbß3 (GPIIb/IIIa) complexes or both IIbß3 and the more ubiquitous vß3 cell membrane complexes are protected from development of atherosclerosis.
Methods and Results— Seven patients with Glanzmann thrombasthenia, 45 to 66 years of age, underwent bilateral carotid artery ultrasonography and screening for risk factors of atherosclerosis. Findings consistent with early atherosclerosis evaluated by measurement of intima-media thickness and presence of atherosclerotic plaques were observed in 6 of the 7 patients. Intima-media thickness values higher than the 75th and 90th percentiles of age- and sex-matched white control subjects of the Atherosclerosis Risk in Communities (ARIC) study were observed in 30 and 8 of 56 carotid artery measurements, respectively. Five of the 6 patients with signs consistent with early atherosclerosis lacked both IIbß3 and vß3 complexes and 1 only lacked IIbß3.
Conclusions— Glanzmann thrombasthenia does not protect affected individuals from development of atherosclerosis.
Key Words: atherosclerosis • carotid arteries • imaging • platelets
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