This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wardeh, A.J. Articles by Serruys, P.W. Search for Related Content PubMed PubMed Citation Articles by Wardeh, A.J. Articles by Serruys, P.W. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Coronary Artery Disease Related Collections Restenosis Catheter-based coronary interventions: stents Other Treatment

(Circulation. 2002;105:550.)
© 2002 American Heart Association, Inc.

Brief Rapid Communications

Angiographical Follow-Up After Radioactive "Cold Ends" Stent Implantation

A Multicenter Trial

A.J. Wardeh, MD, PhD; R. Albiero, MD; I.P. Kay, MBChB, PhD; A.H.M. Knook, MD; W. Wijns, MD, PhD; K. Kozuma, MD, PhD; T. Nishida, MD; V. Ferrero, MD; P.C. Levendag, MD, PhD; W.J. van der Giessen, MD, PhD; A. Colombo, MD; P.W. Serruys, MD, PhD

From Thoraxcenter Rotterdam (A.J.W., I.P.K., A.H.M.K., K.K., W.J.V.D.G., P.W.S.) and the Daniel den Hoed Cancer Center (P.C.L.), University Hospital Rotterdam, Rotterdam, The Netherlands; EMO Centro Cuore Columbus (R.A., T.N., A.C.), Milan, Italy; and Onze Lieve Vrouwe Ziekenhuis (W.W., V.F.), Aalst, Belgium.

Correspondence to Prof Patrick W. Serruys, MD, PhD, Dept of Interventional Cardiology, Thoraxcenter Bd 406, University Hospital Dijkzigt, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands. E-mail Serruys{at}card.azr.nl

Background— Radioactive stents with an activity of 0.75 to 12 µCi have shown >40% edge restenosis due to neointimal hyperplasia and negative remodeling. This trial evaluated whether radioactive Cold Ends stents might resolve edge restenosis by preventing remodeling at the injured extremities.

Methods and Results— The 25-mm long (15-mm radioactive center and 5-mm nonradioactive ends) Cold Ends stents had an activity of 3 to 12 µCi at implantation. Forty-three stents were implanted in 43 patients with de novo native coronary artery disease. Two procedural, 1 subacute, and 1 late stent thrombosis occurred. A restenosis rate of 22% was observed with a shift of the restenosis, usually occurring at the stent edges of radioactive stents, into the Cold Ends stents. The most severe restenosis occurred at the transition zone from radioactive to nonradioactive segments, a region located in dose fall-off.

Conclusion— Cold Ends stents did not resolve edge restenosis.

Key Words: radioisotopes • restenosis • stents

This article has been cited by other articles:

				P. W. Serruys, M. Degertekin, K. Tanabe, M. E. Russell, G. Guagliumi, J. Webb, J. Hamburger, W. Rutsch, C. Kaiser, R. Whitbourn, et al. Vascular Responses at Proximal and Distal Edges of Paclitaxel-Eluting Stents: Serial Intravascular Ultrasound Analysis From the TAXUS II Trial Circulation, February 10, 2004; 109(5): 627 - 633. [Abstract] [Full Text] [PDF]

				R. Seabra-Gomes Intracoronary brachytherapy for restenosis: an efficient technique in the struggle for survival? Eur. Heart J., September 1, 2002; 23(17): 1319 - 1321. [Full Text] [PDF]