Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation
Search: search_blue_button Advanced Search
« Previous Article | Table of Contents | Next Article »
Circulation. 2002;105:85-92
doi: 10.1161/hc0102.101365
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Esposito, G.
Right arrow Articles by Rockman, H. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Esposito, G.
Right arrow Articles by Rockman, H. A.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH
Related Collections
Right arrow Cell signalling/signal transduction
Right arrow Genetically altered mice
Right arrow Hypertrophy

(Circulation. 2002;105:85.)
© 2002 American Heart Association, Inc.

Basic Science Reports

Genetic Alterations That Inhibit In Vivo Pressure-Overload Hypertrophy Prevent Cardiac Dysfunction Despite Increased Wall Stress

Giovanni Esposito, MD; Antonio Rapacciuolo, MD; Sathyamangla V. Naga Prasad, PhD; Hideyuki Takaoka, MD, PhD; Steven A. Thomas, MD, PhD; Walter J. Koch, PhD; Howard A. Rockman, MD

From the Departments of Medicine (G.E., A.R., S.V.N.P., H.T., H.A.R.) and Surgery (W.J.K.), Duke University Medical Center, Durham, NC, and the Department of Pharmacology, University of Pennsylvania, Philadelphia (S.A.T.).

Correspondence to Howard A. Rockman, MD, Department of Medicine, Duke University Medical Center, DUMC 3104, Durham, NC, 27710. E-mail h.rockman{at}duke.edu

Background— A long-standing hypothesis has been that hypertrophy is compensatory and by normalizing wall stress acts to maintain normal cardiac function. Epidemiological data, however, have shown that cardiac hypertrophy is associated with increased mortality, thus casting doubt on the validity of this hypothesis.

Methods and Results— To determine whether cardiac hypertrophy is necessary to preserve cardiac function, we used 2 genetically altered mouse models that have an attenuated hypertrophic response to 8 weeks of pressure overload. End-systolic wall stress ({varsigma}es) obtained by sonomicrometry after 1 week of pressure overload showed complete normalization of {varsigma}es in pressure-overloaded wild-type mice (287±39 versus sham, 254±34 g/cm2), whereas the blunted hypertrophic response in the transgenic mice was inadequate to normalize {varsigma}es (415±81 g/cm2, P<0.05). Remarkably, despite inadequate normalization of {varsigma}es, cardiac function as measured by serial echocardiography showed little deterioration in either of the pressure-overloaded genetic models with blunted hypertrophy. In contrast, wild-type mice with similar pressure overload showed a significant increase in chamber dimensions and progressive deterioration in cardiac function. Analysis of downstream signaling pathways in the late stages of pressure overload suggests that phosphoinositide 3-kinase may play a pivotal role in the transition from hypertrophy to heart failure.

Conclusions— These data suggest that under conditions of pressure overload, the development of cardiac hypertrophy and normalization of wall stress may not be necessary to preserve cardiac function, as previously hypothesized.


Key Words: contractility • hypertrophy • heart failure • receptors, adrenergic, beta • signal transduction




This article has been cited by other articles:


Home page
 Cardiovasc ResHome page
L. Zelarayan, A. Renger, C. Noack, M.-P. Zafiriou, C. Gehrke, R. van der Nagel, R. Dietz, L. de Windt, and M. W. Bergmann
NF-{kappa}B activation is required for adaptive cardiac hypertrophy
Cardiovasc Res, December 1, 2009; 84(3): 416 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
N. S. Chahal, T. K. Lim, P. Jain, J. C. Chambers, J. S. Kooner, and R. Senior
New insights into the relationship of left ventricular geometry and left ventricular mass with cardiac function: a population study of hypertensive subjects
Eur. Heart J., November 19, 2009; (2009) ehp490v1.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. Yoo, A. Lemaire, S. Mangmool, M. J. Wolf, A. Curcio, L. Mao, and H. A. Rockman
{beta}1-Adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction
Am J Physiol Heart Circ Physiol, October 1, 2009; 297(4): H1377 - H1386.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
D. Oceandy, A. Pickard, S. Prehar, M. Zi, T. M.A. Mohamed, P. J. Stanley, F. Baudoin-Stanley, R. Nadif, S. Tommasi, G. P. Pfeifer, et al.
Tumor Suppressor Ras-Association Domain Family 1 Isoform A Is a Novel Regulator of Cardiac Hypertrophy
Circulation, August 18, 2009; 120(7): 607 - 616.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
N. Hedhli and C. Depre
Proteasome inhibitors and cardiac cell growth
Cardiovasc Res, August 7, 2009; (2009) cvp226v2.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
R J Hassink, H Nakajima, H O Nakajima, P A Doevendans, and L J Field
Expression of a transgene encoding mutant p193/CUL7 preserves cardiac function and limits infarct expansion after myocardial infarction
Heart, July 15, 2009; 95(14): 1159 - 1164.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
Y.-H. Choi, D. B. Cowan, A. M. Moran, S. D. Colan, C. Stamm, K. Takeuchi, I. Friehs, P. J. del Nido, and F. X. McGowan Jr.
Myocyte apoptosis occurs early during the development of pressure-overload hypertrophy in infant myocardium.
J. Thorac. Cardiovasc. Surg., June 1, 2009; 137(6): 1356 - 1362.e3.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
F. Jaffre, P. Bonnin, J. Callebert, H. Debbabi, V. Setola, S. Doly, L. Monassier, B. Mettauer, B. C. Blaxall, J.-M. Launay, et al.
Serotonin and Angiotensin Receptors in Cardiac Fibroblasts Coregulate Adrenergic-Dependent Cardiac Hypertrophy
Circ. Res., January 2, 2009; 104(1): 113 - 123.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
K. Athirakul, J. A. Bradbury, J. P. Graves, L. M. DeGraff, J. Ma, Y. Zhao, J. F. Couse, R. Quigley, D. R. Harder, X. Zhao, et al.
Increased blood pressure in mice lacking cytochrome P450 2J5
FASEB J, December 1, 2008; 22(12): 4096 - 4108.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
P. Gallo, M. V.G. Latronico, P. Gallo, S. Grimaldi, F. Borgia, M. Todaro, P. Jones, P. Gallinari, R. De Francesco, G. Ciliberto, et al.
Inhibition of class I histone deacetylase with an apicidin derivative prevents cardiac hypertrophy and failure
Cardiovasc Res, December 1, 2008; 80(3): 416 - 424.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
S. S. Kushwaha, E. Raichlin, Y. Sheinin, W. K. Kremers, K. Chandrasekaran, G. J. Brunn, and J. L. Platt
Sirolimus affects cardiomyocytes to reduce left ventricular mass in heart transplant recipients
Eur. Heart J., November 2, 2008; 29(22): 2742 - 2750.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
N. Hedhli, P. Lizano, C. Hong, L. F. Fritzky, S. K. Dhar, H. Liu, Y. Tian, S. Gao, K. Madura, S. F. Vatner, et al.
Proteasome inhibition decreases cardiac remodeling after initiation of pressure overload
Am J Physiol Heart Circ Physiol, October 1, 2008; 295(4): H1385 - H1393.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Bourajjaj, A.-S. Armand, P. A. da Costa Martins, B. Weijts, R. van der Nagel, S. Heeneman, X. H. Wehrens, and L. J. De Windt
NFATc2 Is a Necessary Mediator of Calcineurin-dependent Cardiac Hypertrophy and Heart Failure
J. Biol. Chem., August 8, 2008; 283(32): 22295 - 22303.
[Abstract] [Full Text] [PDF]

Home page
 Eur J Heart FailHome page
C. Jacobshagen, M. Gruber, N. Teucher, A. G. Schmidt, B. W. Unsold, K. Toischer, P. Nguyen Van, L. S. Maier, H. Kogler, and G. Hasenfuss
Celecoxib modulates hypertrophic signalling and prevents load-induced cardiac dysfunction
Eur J Heart Fail, April 1, 2008; 10(4): 334 - 342.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
J. A. Hill and E. N. Olson
Cardiac Plasticity
N. Engl. J. Med., March 27, 2008; 358(13): 1370 - 1380.
[Full Text] [PDF]

Home page
 CirculationHome page
B. R. DeGeorge Jr, E. Gao, M. Boucher, L. E. Vinge, J. S. Martini, P. W. Raake, J. K. Chuprun, D. M. Harris, G. W. Kim, S. Soltys, et al.
Targeted Inhibition of Cardiomyocyte Gi Signaling Enhances Susceptibility to Apoptotic Cell Death in Response to Ischemic Stress
Circulation, March 18, 2008; 117(11): 1378 - 1387.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
E. A. Woodcock, X.-J. Du, M. E. Reichelt, and R. M. Graham
Cardiac {alpha}1-adrenergic drive in pathological remodelling
Cardiovasc Res, February 1, 2008; 77(3): 452 - 462.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
A. Diwan, J. Wansapura, F. M. Syed, S. J. Matkovich, J. N. Lorenz, and G. W. Dorn II
Nix-Mediated Apoptosis Links Myocardial Fibrosis, Cardiac Remodeling, and Hypertrophy Decompensation
Circulation, January 22, 2008; 117(3): 396 - 404.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart J SupplHome page
P. Pokreisz, G. Marsboom, and S. Janssens
Pressure overload-induced right ventricular dysfunction and remodelling in experimental pulmonary hypertension: the right heart revisited
Eur. Heart J. Suppl., December 1, 2007; 9(suppl_H): H75 - H84.
[Abstract] [Full Text] [PDF]

Home page
 Hum Mol GenetHome page
S. B. Liggett, R. J. Kelly, R. R. Parekh, S. J. Matkovich, B. J. Benner, H. S. Hahn, F. M. Syed, A. S. Galvez, K. L. Case, N. McGuire, et al.
A functional polymorphism of the G{alpha}q (GNAQ) gene is associated with accelerated mortality in African-American heart failure
Hum. Mol. Genet., November 15, 2007; 16(22): 2740 - 2750.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Zhai, S. Gao, E. Holle, X. Yu, A. Yatani, T. Wagner, and J. Sadoshima
Glycogen Synthase Kinase-3{alpha} Reduces Cardiac Growth and Pressure Overload-induced Cardiac Hypertrophy by Inhibition of Extracellular Signal-regulated Kinases
J. Biol. Chem., November 9, 2007; 282(45): 33181 - 33191.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
D. M. Harris, H. I. Cohn, S. Pesant, R.-H. Zhou, and A. D. Eckhart
Vascular smooth muscle Gq signaling is involved in high blood pressure in both induced renal and genetic vascular smooth muscle-derived models of hypertension
Am J Physiol Heart Circ Physiol, November 1, 2007; 293(5): H3072 - H3079.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
B.-G. Kerfant, D. Zhao, I. Lorenzen-Schmidt, L. S. Wilson, S. Cai, S. R. W. Chen, D. H. Maurice, and P. H. Backx
PI3K{gamma} Is Required for PDE4, not PDE3, Activity in Subcellular Microdomains Containing the Sarcoplasmic Reticular Calcium ATPase in Cardiomyocytes
Circ. Res., August 17, 2007; 101(4): 400 - 408.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Cingolani, G. A. Ramirez Correa, E. Kizana, M. Murata, H. C. Cho, and E. Marban
Gene Therapy to Inhibit the Calcium Channel {beta} Subunit: Physiological Consequences and Pathophysiological Effects in Models of Cardiac Hypertrophy
Circ. Res., July 20, 2007; 101(2): 166 - 175.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
A. Diwan and G. W. Dorn II
Decompensation of Cardiac Hypertrophy: Cellular Mechanisms and Novel Therapeutic Targets
Physiology, February 1, 2007; 22(1): 56 - 64.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
N. Sharma, I. C. Okere, M. K. Duda, D. J. Chess, K. M. O'Shea, and W. C. Stanley
Potential impact of carbohydrate and fat intake on pathological left ventricular hypertrophy
Cardiovasc Res, January 15, 2007; 73(2): 257 - 268.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
I. C. Okere, M. E. Young, T. A. McElfresh, D. J. Chess, V. G. Sharov, H. N. Sabbah, B. D. Hoit, P. Ernsberger, M. P. Chandler, and W. C. Stanley
Low Carbohydrate/High-Fat Diet Attenuates Cardiac Hypertrophy, Remodeling, and Altered Gene Expression in Hypertension
Hypertension, December 1, 2006; 48(6): 1116 - 1123.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Rajagopal, E. J. Whalen, J. D. Violin, J. A. Stiber, P. B. Rosenberg, R. T. Premont, T. M. Coffman, H. A. Rockman, and R. J. Lefkowitz
beta-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
PNAS, October 31, 2006; 103(44): 16284 - 16289.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Curcio, T. Noma, S. V. Naga Prasad, M. J. Wolf, A. Lemaire, C. Perrino, L. Mao, and H. A. Rockman
Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling
Am J Physiol Heart Circ Physiol, October 1, 2006; 291(4): H1754 - H1760.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Most, H. Seifert, E. Gao, H. Funakoshi, M. Volkers, J. Heierhorst, A. Remppis, S. T. Pleger, B. R. DeGeorge Jr, A. D. Eckhart, et al.
Cardiac S100A1 Protein Levels Determine Contractile Performance and Propensity Toward Heart Failure After Myocardial Infarction
Circulation, September 19, 2006; 114(12): 1258 - 1268.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
P. Zhai, J. Galeotti, J. Liu, E. Holle, X. Yu, T. Wagner, and J. Sadoshima
An Angiotensin II Type 1 Receptor Mutant Lacking Epidermal Growth Factor Receptor Transactivation Does Not Induce Angiotensin II-Mediated Cardiac Hypertrophy
Circ. Res., September 1, 2006; 99(5): 528 - 536.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. M. Seubert, C. J. Sinal, J. Graves, L. M. DeGraff, J. A. Bradbury, C. R. Lee, K. Goralski, M. A. Carey, A. Luria, J. W. Newman, et al.
Role of Soluble Epoxide Hydrolase in Postischemic Recovery of Heart Contractile Function
Circ. Res., August 18, 2006; 99(4): 442 - 450.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. W. Dorn II
Containing Hypertrophy With a PICOT Fence
Circ. Res., August 4, 2006; 99(3): 228 - 230.
[Full Text] [PDF]

Home page
 HypertensionHome page
N. J. Smith and L. M. Luttrell
Signal Switching, Crosstalk, and Arrestin Scaffolds: Novel G Protein-Coupled Receptor Signaling in Cardiovascular Disease
Hypertension, August 1, 2006; 48(2): 173 - 179.
[Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
B. Swynghedauw
Phenotypic plasticity of adult myocardium: molecular mechanisms
J. Exp. Biol., June 15, 2006; 209(12): 2320 - 2327.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. Matsui, T. Nagoshi, E.-G. Hong, I. Luptak, K. Hartil, L. Li, N. Gorovits, M. J. Charron, J. K. Kim, R. Tian, et al.
Effects of chronic Akt activation on glucose uptake in the heart
Am J Physiol Endocrinol Metab, May 1, 2006; 290(5): E789 - E797.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Perrino and H. A. Rockman
GATA4 and the Two Sides of Gene Expression Reprogramming
Circ. Res., March 31, 2006; 98(6): 715 - 716.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
T. Oka, M. Maillet, A. J. Watt, R. J. Schwartz, B. J. Aronow, S. A. Duncan, and J. D. Molkentin
Cardiac-Specific Deletion of Gata4 Reveals Its Requirement for Hypertrophy, Compensation, and Myocyte Viability
Circ. Res., March 31, 2006; 98(6): 837 - 845.
[Abstract] [Full Text] [PDF]

Home page
 HeartHome page
J. Chambers
The left ventricle in aortic stenosis: evidence for the use of ACE inhibitors.
Heart, March 1, 2006; 92(3): 420 - 423.
[Full Text] [PDF]

Home page
 Toxicol PatholHome page
Y. J. Kang
Cardiac Hypertrophy: A Risk Factor for QT-Prolongation and Cardiac Sudden Death
Toxicol Pathol, January 1, 2006; 34(1): 58 - 66.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. Munch, K. Rosport, A. Bultmann, C. Baumgartner, Z. Li, L. Laacke, and M. Ungerer
Cardiac Overexpression of the Norepinephrine Transporter Uptake-1 Results in Marked Improvement of Heart Failure
Circ. Res., October 28, 2005; 97(9): 928 - 936.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Wettschureck and S. Offermanns
Mammalian G Proteins and Their Cell Type Specific Functions
Physiol Rev, October 1, 2005; 85(4): 1159 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
M. Kupari, H. Turto, and J. Lommi
Left ventricular hypertrophy in aortic valve stenosis: preventive or promotive of systolic dysfunction and heart failure?
Eur. Heart J., September 1, 2005; 26(17): 1790 - 1796.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
H. P.J. Buermans and W. J. Paulus
Iconoclasts topple adaptive myocardial hypertrophy in aortic stenosis
Eur. Heart J., September 1, 2005; 26(17): 1697 - 1699.
[Full Text] [PDF]

Home page
 HypertensionHome page
C. F. Deschepper
The Many Possible Benefits of Natriuretic Peptides After Myocardial Infarction
Hypertension, August 1, 2005; 46(2): 271 - 272.
[Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
C. Perrino, S. V. Naga Prasad, M. Patel, M. J. Wolf, and H. A. Rockman
Targeted Inhibition of {beta}-Adrenergic Receptor Kinase-1-Associated Phosphoinositide-3 Kinase Activity Preserves {beta}-Adrenergic Receptor Signaling and Prolongs Survival in Heart Failure Induced by Calsequestrin Overexpression
J. Am. Coll. Cardiol., June 7, 2005; 45(11): 1862 - 1870.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
B.-G. Kerfant, D. Gidrewicz, H. Sun, G. Y. Oudit, J. M. Penninger, and P. H. Backx
Cardiac Sarcoplasmic Reticulum Calcium Release and Load Are Enhanced by Subcellular cAMP Elevations in PI3K{gamma}-Deficient Mice
Circ. Res., May 27, 2005; 96(10): 1079 - 1086.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. De Acetis, A. Notte, F. Accornero, G. Selvetella, M. Brancaccio, C. Vecchione, M. Sbroggio, F. Collino, B. Pacchioni, G. Lanfranchi, et al.
Cardiac Overexpression of Melusin Protects From Dilated Cardiomyopathy Due to Long-Standing Pressure Overload
Circ. Res., May 27, 2005; 96(10): 1087 - 1094.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. Perrino, S. V. Naga Prasad, J. N. Schroder, J. A. Hata, C. Milano, and H. A. Rockman
Restoration of {beta}-Adrenergic Receptor Signaling and Contractile Function in Heart Failure by Disruption of the {beta}ARK1/Phosphoinositide 3-Kinase Complex
Circulation, May 24, 2005; 111(20): 2579 - 2587.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. Kozakova, A. G. Fraser, S. Buralli, A. Magagna, A. Salvetti, E. Ferrannini, and C. Palombo
Reduced Left Ventricular Functional Reserve in Hypertensive Patients With Preserved Function at Rest
Hypertension, April 1, 2005; 45(4): 619 - 624.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. W. Booz
Putting the Brakes on Cardiac Hypertrophy: Exploiting the NO-cGMP Counter-Regulatory System
Hypertension, March 1, 2005; 45(3): 341 - 346.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
H. Tachibana, S. V. Naga Prasad, R. J. Lefkowitz, W. J. Koch, and H. A. Rockman
Level of {beta}-Adrenergic Receptor Kinase 1 Inhibition Determines Degree of Cardiac Dysfunction After Chronic Pressure Overload-Induced Heart Failure
Circulation, February 8, 2005; 111(5): 591 - 597.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
R. Arya, V. Kedar, J. R. Hwang, H. McDonough, H.-H. Li, J. Taylor, and C. Patterson
Muscle ring finger protein-1 inhibits PKC{epsilon} activation and prevents cardiomyocyte hypertrophy
J. Cell Biol., December 20, 2004; 167(6): 1147 - 1159.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. W. Holmes
Candidate mechanical stimuli for hypertrophy during volume overload
J Appl Physiol, October 1, 2004; 97(4): 1453 - 1460.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J. Seubert, B. Yang, J. A. Bradbury, J. Graves, L. M. Degraff, S. Gabel, R. Gooch, J. Foley, J. Newman, L. Mao, et al.
Enhanced Postischemic Functional Recovery in CYP2J2 Transgenic Hearts Involves Mitochondrial ATP-Sensitive K+ Channels and p42/p44 MAPK Pathway
Circ. Res., September 3, 2004; 95(5): 506 - 514.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
G. Selvetella, E. Hirsch, A. Notte, G. Tarone, and G. Lembo
Adaptive and maladaptive hypertrophic pathways: points of convergence and divergence
Cardiovasc Res, August 15, 2004; 63(3): 373 - 380.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
L. Barki-Harrington, C. Perrino, and H. A Rockman
Network integration of the adrenergic system in cardiac hypertrophy
Cardiovasc Res, August 15, 2004; 63(3): 391 - 402.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
B. Fiedler and K. C Wollert
Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes
Cardiovasc Res, August 15, 2004; 63(3): 450 - 457.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
V. P.M van Empel and L. J De Windt
Myocyte hypertrophy and apoptosis: a balancing act
Cardiovasc Res, August 15, 2004; 63(3): 487 - 499.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
N. Frey, H. A. Katus, E. N. Olson, and J. A. Hill
Hypertrophy of the Heart: A New Therapeutic Target?
Circulation, April 6, 2004; 109(13): 1580 - 1589.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
G. de Simone
Concentric or Eccentric Hypertrophy: How Clinically Relevant Is the Difference?
Hypertension, April 1, 2004; 43(4): 714 - 715.
[Full Text] [PDF]

Home page
 Circ. Res.Home page
E. van Rooij, P. A. Doevendans, H. J.G.M. Crijns, S. Heeneman, D. J. Lips, M. van Bilsen, R. S. Williams, E. N. Olson, R. Bassel-Duby, B. A. Rothermel, et al.
MCIP1 Overexpression Suppresses Left Ventricular Remodeling and Sustains Cardiac Function After Myocardial Infarction
Circ. Res., February 20, 2004; 94 (3): e18 - e26.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
G. W. Dorn II and J. D. Molkentin
Manipulating Cardiac Contractility in Heart Failure: Data From Mice and Men
Circulation, January 20, 2004; 109(2): 150 - 158.
[Full Text] [PDF]

Home page
 Recent Prog Horm ResHome page
J.R. Keys and W.J. Koch
The Adrenergic Pathway and Heart Failure
Recent Prog. Horm. Res., January 1, 2004; 59(1): 13 - 30.
[Abstract] [Full Text]

Home page
 Hum Mol GenetHome page
P. Le Corvoisier, H.-Y. Park, K. M. Carlson, D. A. Marchuk, and H. A. Rockman
Multiple quantitative trait loci modify the heart failure phenotype in murine cardiomyopathy
Hum. Mol. Genet., December 1, 2003; 12(23): 3097 - 3107.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
Y. Liao, S. Takashima, Y. Asano, M. Asakura, A. Ogai, Y. Shintani, T. Minamino, H. Asanuma, S. Sanada, J. Kim, et al.
Activation of Adenosine A1 Receptor Attenuates Cardiac Hypertrophy and Prevents Heart Failure in Murine Left Ventricular Pressure-Overload Model
Circ. Res., October 17, 2003; 93(8): 759 - 766.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
J. R. McMullen, T. Shioi, L. Zhang, O. Tarnavski, M. C. Sherwood, P. M. Kang, and S. Izumo
Phosphoinositide 3-kinase(p110{alpha}) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy
PNAS, October 14, 2003; 100(21): 12355 - 12360.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
L. Barki-Harrington, L. M. Luttrell, and H. A. Rockman
Dual Inhibition of {beta}-Adrenergic and Angiotensin II Receptors by a Single Antagonist: A Functional Role for Receptor-Receptor Interaction In Vivo
Circulation, September 30, 2003; 108(13): 1611 - 1618.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
Y. Chen, S. Park, Y. Li, E. Missov, M. Hou, X. Han, J. L. Hall, L. W. Miller, and R. J. Bache
Alterations of gene expression in failing myocardium following left ventricular assist device support
Physiol Genomics, August 15, 2003; 14(3): 251 - 260.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. L. Antos, T. A. McKinsey, M. Dreitz, L. M. Hollingsworth, C.-L. Zhang, K. Schreiber, H. Rindt, R. J. Gorczynski, and E. N. Olson
Dose-dependent Blockade to Cardiomyocyte Hypertrophy by Histone Deacetylase Inhibitors
J. Biol. Chem., August 1, 2003; 278(31): 28930 - 28937.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Schoenmakers, C. Ramakers, J. M. van Opstal, J. D.M. Leunissen, C. Londono, and M. A. Vos
Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog
Cardiovasc Res, August 1, 2003; 59(2): 351 - 359.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
G. W. Dorn II, J. Robbins, and P. H. Sugden
Phenotyping Hypertrophy: Eschew Obfuscation
Circ. Res., June 13, 2003; 92(11): 1171 - 1175.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
D. J. Lips, L. J. deWindt, D. J.W. van Kraaij, and P. A. Doevendans
Molecular determinants of myocardial hypertrophy and failure: alternative pathways for beneficial and maladaptive hypertrophy
Eur. Heart J., May 2, 2003; 24(10): 883 - 896.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. S. Scopacasa, V. P. A. Teixeira, and K. G. Franchini
Colchicine attenuates left ventricular hypertrophy but preserves cardiac function of aortic-constricted rats
J Appl Physiol, April 1, 2003; 94(4): 1627 - 1633.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Morisco, J. Sadoshima, B. Trimarco, R. Arora, D. E. Vatner, and S. F. Vatner
Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus
Am J Physiol Heart Circ Physiol, April 1, 2003; 284 (4): H1043 - H1047.
[Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. M. Colomer, L. Mao, H. A. Rockman, and A. R. Means
Pressure Overload Selectively Up-Regulates Ca2+/Calmodulin-Dependent Protein Kinase II in Vivo
Mol. Endocrinol., February 1, 2003; 17(2): 183 - 192.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
I. Sjaastad, J A. Wasserstrom, and O. M Sejersted
Heart failure - a challenge to our current concepts of excitation-contraction coupling
J. Physiol., January 1, 2003; 546(1): 33 - 47.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
S. Nemoto, G. DeFreitas, D. L. Mann, and B. A. Carabello
Effects of changes in left ventricular contractility on indexes of contractility in mice
Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2504 - H2510.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
M. A. Sussman, A. McCulloch, and T. K. Borg
Dance Band on the Titanic: Biomechanical Signaling in Cardiac Hypertrophy
Circ. Res., November 15, 2002; 91(10): 888 - 898.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. R. Keys, E. A. Greene, W. J. Koch, and A. D. Eckhart
Gq-Coupled Receptor Agonists Mediate Cardiac Hypertrophy Via the Vasculature
Hypertension, November 1, 2002; 40(5): 660 - 666.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
R. Nishio, S. Sasayama, and A. Matsumori
Left ventricular pressure-volume relationship in a murine model of congestive heart failure due to acute viral myocarditis
J. Am. Coll. Cardiol., October 16, 2002; 40(8): 1506 - 1514.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
C. Indolfi, E. Di Lorenzo, C. Perrino, A. M. Stingone, A. Curcio, D. Torella, A. Cittadini, L. Cardone, C. Coppola, L. Cavuto, et al.
Hydroxymethylglutaryl Coenzyme A Reductase Inhibitor Simvastatin Prevents Cardiac Hypertrophy Induced by Pressure Overload and Inhibits p21ras Activation
Circulation, October 15, 2002; 106(16): 2118 - 2124.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. Fatkin and R. M. Graham
Molecular Mechanisms of Inherited Cardiomyopathies
Physiol Rev, October 1, 2002; 82(4): 945 - 980.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Kim, A. D. Eckhart, S. Eguchi, and W. J. Koch
beta -Adrenergic Receptor-mediated DNA Synthesis in Cardiac Fibroblasts Is Dependent on Transactivation of the Epidermal Growth Factor Receptor and Subsequent Activation of Extracellular Signal-regulated Kinases
J. Biol. Chem., August 23, 2002; 277(35): 32116 - 32123.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
B. J Wilkins and J. D Molkentin
Calcineurin and cardiac hypertrophy: Where have we been? Where are we going?
J. Physiol., May 15, 2002; 541(1): 1 - 8.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. A. Hill, B. Rothermel, K.-D. Yoo, B. Cabuay, E. Demetroulis, R. M. Weiss, W. Kutschke, R. Bassel-Duby, and R. S. Williams
Targeted Inhibition of Calcineurin in Pressure-overload Cardiac Hypertrophy. PRESERVATION OF SYSTOLIC FUNCTION
J. Biol. Chem., March 15, 2002; 277(12): 10251 - 10255.
[Abstract] [Full Text] [PDF]

Home page
 Cold Spring Harb Symp Quant BiolHome page
S.V. NAGA PRASAD, J. NIENABER, and H.A. ROCKMAN
G-Protein-coupled Receptor Function in Heart Failure
Cold Spring Harb Symp Quant Biol, January 1, 2002; 67(0): 439 - 444.
[Abstract] [PDF]

Home page
 CirculationHome page
M. Sano and M. D. Schneider
Still Stressed Out but Doing Fine: Normalization of Wall Stress Is Superfluous to Maintaining Cardiac Function in Chronic Pressure Overload
Circulation, January 1, 2002; 105(1): 8 - 10.
[Full Text] [PDF]

Home page
 CirculationHome page
M. Suzuki, K. M. Carlson, D. A. Marchuk, and H. A. Rockman
Genetic Modifier Loci Affecting Survival and Cardiac Function in Murine Dilated Cardiomyopathy
Circulation, April 16, 2002; 105(15): 1824 - 1829.
[Abstract] [Full Text] [PDF]


Circulation Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search
Copyright © 2002 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited.