doi: 10.1161/hc2901.093115
(Circulation. 2001;104:393.)
© 2001 American Heart Association, Inc.
Clinical Investigation and Reports |
Maternal and Paternal History of Myocardial Infarction and Risk of Cardiovascular Disease in Men and Women
From the Division of Preventive Medicine (H.D.S., I.-M.L., J.M.G., K.M.R., R.J.G., J.E.B.), Brigham and Women’s Hospital, Boston, Mass; Department of Epidemiology (H.D.S., I.-M.L., J.M.G., J.E.B.) and Department of Biostatistics (R.J.G.), Harvard School of Public Health, Boston, Mass; Massachusetts Veterans Epidemiology Research and Information Center (H.D.S., J.M.G.), Veterans Affairs Medical Center, Boston, Mass; and Department of Ambulatory Care and Prevention (J.E.B.), Harvard Medical School, Boston, Mass.
Correspondence to Howard D. Sesso, Brigham and Women’s Hospital, 900 Commonwealth Ave E, Boston, MA 02215-1204. E-mail hsesso{at}hsph.harvard.edu
Background— Few studies have examined the effects of paternal and maternal history of myocardial infarction (MI), including age at MI, on cardiovascular disease (CVD) risk, particularly among women.
Methods and Results— We prospectively studied 22 071 men from the Physicians’ Health Study and 39 876 women from the Women’s Health Study with data on parental history and age at MI. Among men, 2654 CVD cases developed over 13.0 years; among women, 563 CVD cases occurred over 6.2 years. Compared with men with no parental history, only maternal, only paternal, and both maternal and paternal history of MI conferred relative risks (RRs) of CVD of 1.71, 1.40, and 1.85; among women, the respective RRs were 1.46, 1.15, and 2.05. For men, maternal age at MI of <50, 50 to 59, 60 to 69, 70 to 79, and 
80 years had RRs of 1.00, 1.88, 1.88, 1.67, and 1.17; for women, the RRs for maternal age at MI of <50, 50 to 59, and 60 years were 2.57, 1.33, and 1.52. Paternal age at MI of <50, 50 to 59, 60 to 69, 70 to 79, and 80 years in men had RRs of 2.19, 1.64, 1.42, 1.16, and 0.92; in women, for paternal age at MI of <50, 50 to 59, and 60 years, the RRs were 1.63, 1.33, and 1.13.
Conclusions— An early history of parental MI (<60 years) conferred a greater risk of CVD than did MI at older ages. However, an increased risk of CVD remained for maternal age at MI of 70 to 79 years in men and 60 years in women, which suggests that any maternal history of MI may be important.
Key Words: myocardial infarction • risk factors • cardiovascular diseases • epidemiology • prevention
This article has been cited by other articles:
 |
|
 |
|
  M. Fischer, B. Mayer, A. Baessler, G. Riegger, J. Erdmann, C. Hengstenberg, and H. Schunkert Familial aggregation of left main coronary artery disease and future risk of coronary events in asymptomatic siblings of affected patients Eur. Heart J., October 3, 2007; (2007) ehm377v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. I. Parikh, S.-J. Hwang, M. G. Larson, L. A. Cupples, C. S. Fox, E. S. Manders, J. M. Murabito, J. M. Massaro, U. Hoffmann, and C. J. O'Donnell Parental Occurrence of Premature Cardiovascular Disease Predicts Increased Coronary Artery and Abdominal Aortic Calcification in the Framingham Offspring and Third Generation Cohorts Circulation, September 25, 2007; 116(13): 1473 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. K. Arnett, A. E. Baird, R. A. Barkley, C. T. Basson, E. Boerwinkle, S. K. Ganesh, D. M. Herrington, Y. Hong, C. Jaquish, D. A. McDermott, et al. Relevance of Genetics and Genomics for Prevention and Treatment of Cardiovascular Disease: A Scientific Statement From the American Heart Association Council on Epidemiology and Prevention, the Stroke Council, and the Functional Genomics and Translational Biology Interdisciplinary Working Group Circulation, June 5, 2007; 115(22): 2878 - 2901. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. M Ridker, J. E. Buring, N. Rifai, and N. R. Cook Development and Validation of Improved Algorithms for the Assessment of Global Cardiovascular Risk in Women: The Reynolds Risk Score JAMA, February 14, 2007; 297(6): 611 - 619. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Jones and C. P. Carney Mental Disorders and Revascularization Procedures in a Commercially Insured Sample Psychosom Med, July 1, 2005; 67(4): 568 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mora, L. R. Yanek, T. F. Moy, M. D. Fallin, L. C. Becker, and D. M. Becker Interaction of Body Mass Index and Framingham Risk Score in Predicting Incident Coronary Disease in Families Circulation, April 19, 2005; 111(15): 1871 - 1876. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. O'Donnell Family History, Subclinical Atherosclerosis, and Coronary Heart Disease Risk: Barriers and Opportunities for the Use of Family History Information in Risk Prediction and Prevention Circulation, October 12, 2004; 110(15): 2074 - 2076. [Full Text] [PDF]
|
|
|
|
|
|
K. Nasir, E. D. Michos, J. A. Rumberger, J. B. Braunstein, W. S. Post, M. J. Budoff, and R. S. Blumenthal Coronary Artery Calcification and Family History of Premature Coronary Heart Disease: Sibling History Is More Strongly Associated Than Parental History Circulation, October 12, 2004; 110(15): 2150 - 2156. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Lloyd-Jones, B.-H. Nam, R. B. D'Agostino Sr, D. Levy, J. M. Murabito, T. J. Wang, P. W. F. Wilson, and C. J. O'Donnell Parental Cardiovascular Disease as a Risk Factor for Cardiovascular Disease in Middle-aged Adults: A Prospective Study of Parents and Offspring JAMA, May 12, 2004; 291(18): 2204 - 2211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Murabito, B.-H. Nam, R. B. D'Agostino Sr., D. M. Lloyd-Jones, C. J. O'Donnell, and P. W.F. Wilson Accuracy of Offspring Reports of Parental Cardiovascular Disease History: The Framingham Offspring Study Ann Intern Med, March 16, 2004; 140(6): 434 - 440. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Flossmann, U. G.R. Schulz, and P. M. Rothwell Systematic Review of Methods and Results of Studies of the Genetic Epidemiology of Ischemic Stroke Stroke, January 1, 2004; 35(1): 212 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S Parmar Family history of coronary artery disease -- need to focus on proper definition! Eur. Heart J., November 2, 2003; 24(22): 2073 - 2073. [Full Text] [PDF]
|
|
|
|
|
|
T. J. Wang, B.-H. Nam, R. B. D'Agostino, P. A. Wolf, D. M. Lloyd-Jones, C. A. MacRae, P. W. Wilson, J. F. Polak, and C. J. O'Donnell Carotid Intima-Media Thickness Is Associated With Premature Parental Coronary Heart Disease: The Framingham Heart Study Circulation, August 5, 2003; 108(5): 572 - 576. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R F Redberg Are there sex differences in risk factors for coronary heart disease? Maternal versus paternal transmission Heart, August 1, 2003; 89(8): 817 - 818. [Full Text] [PDF]
|
|
|
|
|
|
S Kinra, G Davey Smith, M Okasha, P McCarron, and J McEwen Is maternal transmission of coronary heart disease risk stronger than paternal transmission? Heart, August 1, 2003; 89(8): 834 - 838. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J De Sutter, D De Bacquer, K Kotseva, S Sans, K Pyorala, D Wood, G De Backer, and on behalf of the EUROASPIRE II study group Screening of family members of patients with premature coronary heart disease: Results from the EUROASPIRE II family survey Eur. Heart J., February 1, 2003; 24(3): 249 - 257. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Stangl, G. Baumann, and K. Stangl Coronary atherogenic risk factors in women Eur. Heart J., November 2, 2002; 23(22): 1738 - 1752. [Full Text] [PDF]
|
|
|
|
|
|
J. Simon and H. Rosolova Family history--and independent risk factors for coronary heart disease, it is time to be practical Eur. Heart J., November 1, 2002; 23(21): 1637 - 1638. [Full Text] [PDF]
|
|
|
|
 |
|
 Increased Cardiovascular Risk with Parental History of MI Journal Watch Women's Health, September 18, 2001; 2001(918): 2 - 2. [Full Text]
|
|