Circulation. 2001;104:3052-3056
doi: 10.1161/hc5001.101061
doi: 10.1161/hc5001.101061
(Circulation. 2001;104:3052.)
© 2001 American Heart Association, Inc.
Clinical Investigation and Reports |
Plasma Leptin and the Risk of Cardiovascular Disease in the West of Scotland Coronary Prevention Study (WOSCOPS)
From the Department of Pathological Biochemistry (A.M.W., C.J.P., A.K., J.S., N.S.), Clinical Trials Unit (A.G.), Glasgow Royal Infirmary, and Robertson Centre for Biostatistics (A.D.M.), University of Glasgow, Glasgow, Scotland.
Correspondence to Dr Naveed Sattar, Department of Pathological Biochemistry, 4th Floor QEB, Glasgow Royal Infirmary, Glasgow G31 2ER, UK. E-mail nsattar{at}clinmed.gla.ac.uk
Background— Leptin plays a role in fat metabolism and correlates with insulin resistance and other markers of the metabolic syndrome, independent of total adiposity. Therefore, we hypothesized that raised leptin levels may identify men at increased risk of a coronary event in the West of Scotland Coronary Prevention Study (WOSCOPS).
Methods and Results— Plasma leptin levels were measured at baseline in 377 men (cases) who subsequently experienced a coronary event and in 783 men (controls) who remained free of an event during the 5-year follow-up period of the study. Controls were matched to cases on the basis of age and smoking history and were representative of the entire WOSCOPS cohort. Leptin levels were significantly higher in cases than controls (5.87±2.04 ng/mL versus 5.04±2.09 ng/mL, P<0.001). In univariate analysis, for each 1 SD increase in leptin, the relative risk (RR) of an event increased by 1.25 (95% confidence interval [CI], 1.10 to 1.43; P<0.001). There was minimal change in this RR with correction for body mass index (RR, 1.24; 95% CI, 1.06 to 1.45; P=0.006) or with further correction for classic risk factors, including age, lipids, and systolic blood pressure (RR, 1.20; 95% CI, 1.02 to 1.42; P=0.03). Leptin correlated with C-reactive protein (r=0.24, P<0.001) and, even with this variable added to the model, leptin retained significance as a predictor of coronary events (RR, 1.18; 95% CI, 1.00 to 1.39; P=0.05) at the expense of C-reactive protein.
Conclusions— We show, for the first time, in a large prospective study that leptin is a novel, independent risk factor for coronary heart disease.
Key Words: adipocytes • insulin resistance • inflammation • cardiovascular diseases
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 A. S. M. Shamsuzzaman, B. J. Gersh, and V. K. Somers Obstructive Sleep Apnea: Implications for Cardiac and Vascular Disease JAMA, October 8, 2003; 290(14): 1906 - 1914. [Abstract] [Full Text] [PDF]
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L. Piemonti, G. Calori, A. Mercalli, G. Lattuada, P. Monti, M. P. Garancini, F. Costantino, G. Ruotolo, L. Luzi, and G. Perseghin Fasting Plasma Leptin, Tumor Necrosis Factor-{alpha} Receptor 2, and Monocyte Chemoattracting Protein 1 Concentration in a Population of Glucose-Tolerant and Glucose-Intolerant Women: Impact on cardiovascular mortality Diabetes Care, October 1, 2003; 26(10): 2883 - 2889. [Abstract] [Full Text] [PDF]
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M. P. Reilly and D. J. Rader The Metabolic Syndrome: More Than the Sum of Its Parts? Circulation, September 30, 2003; 108(13): 1546 - 1551. [Full Text] [PDF]
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M. Tomaszewski, F. J. Charchar, M. Przybycin, L. Crawford, A. M. Wallace, K. Gosek, G. D. Lowe, E. Zukowska-Szczechowska, W. Grzeszczak, N. Sattar, et al. Strikingly Low Circulating CRP Concentrations in Ultramarathon Runners Independent of Markers of Adiposity: How Low Can You Go? Arterioscler Thromb Vasc Biol, September 1, 2003; 23(9): 1640 - 1644. [Abstract] [Full Text] [PDF]
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V. Rajapurohitam, X. T. Gan, L. A. Kirshenbaum, and M. Karmazyn The Obesity-Associated Peptide Leptin Induces Hypertrophy in Neonatal Rat Ventricular Myocytes Circ. Res., August 22, 2003; 93(4): 277 - 279. [Abstract] [Full Text] [PDF]
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 D D Sin and S F P Man Impaired lung function and serum leptin in men and women with normal body weight: a population based study Thorax, August 1, 2003; 58(8): 695 - 698. [Abstract] [Full Text] [PDF]
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 T. Saaresranta and O. Polo Sleep-disordered breathing and hormones Eur. Respir. J., July 1, 2003; 22(1): 161 - 172. [Abstract] [Full Text] [PDF]
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N. Sattar, J. Ramsay, L. Crawford, H. Cheyne, and I. A. Greer Classic and Novel Risk Factor Parameters in Women With a History of Preeclampsia Hypertension, July 1, 2003; 42(1): 39 - 42. [Abstract] [Full Text] [PDF]
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R. A. Anderson, A. M. Wallace, N. Sattar, N. Kumar, and K. Sundaram Evidence for Tissue Selectivity of the Synthetic Androgen 7{alpha}-Methyl-19-Nortestosterone in Hypogonadal Men J. Clin. Endocrinol. Metab., June 1, 2003; 88(6): 2784 - 2793. [Abstract] [Full Text] [PDF]
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 N. Sattar, C. G Perry, and J. R Petrie Type 2 diabetes as an inflammatory disorder The British Journal of Diabetes & Vascular Disease, January 1, 2003; 3(1): 36 - 41. [Abstract] [PDF]
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 N. G. Patel, J. C. Holder, S. A. Smith, S. Kumar, and M. C. Eggo Differential Regulation of Lipogenesis and Leptin Production by Independent Signaling Pathways and Rosiglitazone During Human Adipocyte Differentiation Diabetes, January 1, 2003; 52(1): 43 - 50. [Abstract] [Full Text] [PDF]
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M. Kratz, A. von Eckardstein, M. Fobker, A. Buyken, N. Posny, H. Schulte, G. Assmann, and U. Wahrburg The Impact of Dietary Fat Composition on Serum Leptin Concentrations in Healthy Nonobese Men and Women J. Clin. Endocrinol. Metab., November 1, 2002; 87(11): 5008 - 5014. [Abstract] [Full Text] [PDF]
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A. Singhal, I. S. Farooqi, T. J. Cole, S. O'Rahilly, M. Fewtrell, M. Kattenhorn, A. Lucas, and J. Deanfield Influence of Leptin on Arterial Distensibility: A Novel Link Between Obesity and Cardiovascular Disease? Circulation, October 8, 2002; 106(15): 1919 - 1924. [Abstract] [Full Text] [PDF]
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A. J Krentz Type 2 diabetes and atherosclerotic cardiovascular disease: do they share common antecedents? The British Journal of Diabetes & Vascular Disease, September 1, 2002; 2(5): 370 - 378. [Abstract] [PDF]
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A. E. Pontiroli, P. Pizzocri, F. Folli, N. Sattar, P. W. Macfarlane, C. J. Packard, A. Kelly, J. Shepherd, A. Gaw, A. M. Wallace, et al. Plasma Leptin Levels and Coronary Heart Disease * Response Circulation, August 27, 2002; 106 (9): e42 - e42. [Full Text] [PDF]
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F. Corica, A. Corsonello, F. Perticone, P. F. Bodary, and D. T. Eitzman Effects of Leptin on Platelet Function in Obese Patients JAMA, July 17, 2002; 288(3): 313 - 314. [Full Text] [PDF]
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M. Winnicki, V. K. Somers, V. Accurso, B. G. Phillips, M. Puato, P. Palatini, and P. Pauletto Fish-Rich Diet, Leptin, and Body Mass Circulation, July 16, 2002; 106(3): 289 - 291. [Abstract] [Full Text] [PDF]
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C. Bernal-Mizrachi, S. Weng, B. Li, L. A. Nolte, C. Feng, T. Coleman, J. O. Holloszy, and C. F. Semenkovich Respiratory Uncoupling Lowers Blood Pressure Through a Leptin-Dependent Mechanism in Genetically Obese Mice Arterioscler Thromb Vasc Biol, June 1, 2002; 22(6): 961 - 968. [Abstract] [Full Text] [PDF]
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P. F. Bodary, R. J. Westrick, K. J. Wickenheiser, Y. Shen, and D. T. Eitzman Effect of Leptin on Arterial Thrombosis Following Vascular Injury in Mice JAMA, April 3, 2002; 287(13): 1706 - 1709. [Abstract] [Full Text] [PDF]
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