This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hehrlein, C. Articles by Fischell, T. A. Search for Related Content PubMed PubMed Citation Articles by Hehrlein, C. Articles by Fischell, T. A. Related Collections Restenosis Restenosis Catheter-based coronary interventions: stents

(Circulation. 2001;104:2358.)
© 2001 American Heart Association, Inc.

Basic Science Reports

Failure of a Novel Balloon-Expandable -Emitting (¹⁰³Pd) Stent to Prevent Edge Effects

Christoph Hehrlein, MD; Jennifer J. DeVries, LATG; Amina Arab, MD; Scott D. Haller, BS; Klaus Schloesser, PhD; Ferman O. Tio, MD; Tim A. Fischell, MD

From the Department of Cardiology, University of Freiburg (C.H., A.A.), and the Forschungszentrum Karlsruhe (K.S.), Germany; the Department of Pathology, University of San Antonio, Tex (F.O.T.); and the Heart Institute, Cardiovascular Research, Borgess Medical Center, Kalamazoo, Mich (J.J.D., S.D.H., T.A.F.).

Correspondence to Christoph Hehrlein, MD, Associate Professor of Medicine, Department of Cardiology, University Hospital Freiburg, Hugstetterstraße 55, 79106 Freiburg im Breisgau, Germany. E-mail hehrlein{at}med1.ukl.uni-freiburg.de

Background— Balloon-expandable ß-particle–emitting (³²P) stents inhibit within-stent neointimal hyperplasia but induce lumen narrowing beyond the stent margins, ie, the so-called "edge effects."

Methods and Results— We prospectively investigated the performance of novel stents impregnated with the -emitting isotope ¹⁰³Pd, designed to reduce edge effects, in 24 rabbits. The stents had a length of 18 mm and were mounted on 20-mm-long delivery balloons for deployment. Angiograms were obtained immediately and 1 month after direct implantation of control and 1-, 2-, and 4-mCi ¹⁰³Pd stents into the iliac arteries without predilatation or postdilatation. Late lumen loss was measured with quantitative angiography. Neointimal hyperplasia and vascular remodeling were evaluated by histomorphometry. Late lumen loss was inhibited within ¹⁰³Pd stents (control 0.18 mm, 1 mCi 0.08 mm, 2 mCi 0.05 mm, and 4 mCi -0.03 mm, P<0.05 all activities versus control). Conversely, late lumen loss occurred at the edges of ¹⁰³Pd stents, correlating with areas of high balloon/artery ratios and vessel overstretch injury. Edge effects were primarily due to neointimal hyperplasia but were also caused by negative vessel remodeling at high stent activities.

Conclusions— Edge effects after implantation of radioisotope stents can occur independently of the isotope chosen for stent impregnation.

Key Words: radioisotopes • remodeling • restenosis • stents

This article has been cited by other articles:

				C. Haller Percutaneous coronary interventions in patients with renal failure: overcoming in-stent restenosis? Nephrol. Dial. Transplant., May 1, 2002; 17(5): 701 - 703. [Full Text] [PDF]