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(Circulation. 2001;104:2269.)
© 2001 American Heart Association, Inc.

Brief Rapid Communications

n-3 Polyunsaturated Fatty Acids, Fish, and Nonfatal Acute Myocardial Infarction

Alessandra Tavani, SciD; Claudio Pelucchi, SciD; Eva Negri, SciD; Michaela Bertuzzi, SciD; Carlo La Vecchia, MD

From the Istituto di Ricerche Farmacologiche "Mario Negri" (A.T., C.P., E.N., M.B., C.L.V.) and the Istituto di Statistica Medica e Biometria, Università degli Studi di Milano (C.L.V.), Milan, Italy.

Correspondence to Alessandra Tavani, Istituto di Ricerche Farmacologiche "Mario Negri", Via Eritrea 62, 20157 Milano, Italy. E-mail tavani{at}marionegri.it

Background— The relation between n-3 polyunsaturated fatty acids (PUFAs), fish intake, and risk of coronary heart disease is controversial.

Methods and Results— An Italian case-control study including 507 patients with nonfatal acute myocardial infarction (AMI) and 478 hospital controls found a multivariate odds ratio (OR) of 0.67 (95% CI, 0.47 to 0.95) for the highest n-3 PUFA intake and 0.68 (95% CI, 0.47 to 0.98) for an intake of >1 portion of fish per week compared with 2 portions per week.

Conclusions— Small amounts of n-3 PUFAs may be inversely related to AMI risk in this low-risk population.

Key Words: myocardial infarction • epidemiology • diet • fatty acids • risk factors

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