doi: 10.1161/hc4301.097195
(Circulation. 2001;104:2228.)
© 2001 American Heart Association, Inc.
Basic Science Reports |
Perivascular Inflammation After Balloon Angioplasty of Porcine Coronary Arteries
From the Winship Cancer Institute (E.O., T.C., H.D.L., J.N.W.), the Department of Surgery (J.V.-J.), and the Department of Medicine (N.A.S.), Emory University, Atlanta, Ga; and the Department of Medicine (R.B.G.), University of Washington, Seattle. Dr Okamoto is currently affiliated with the Second Department of Internal Medicine, Gunma University, Gunma, Japan, and Dr De Leon is currently affiliated with the Atlanta Cardiovascular Research Institute, Norcross, Ga.
Correspondence to Josiah N. Wilcox, PhD, Emory University, Division of Hematology/Oncology, 1639 Pierce Dr, Room 1115 WMRB, Atlanta, GA 30322. E-mail medjnw{at}emory.edu
Background— Inflammation has been suggested to play a role in vascular lesion formation after angioplasty. Whereas previous studies have focused on inflammatory reactions in the intima and media, less attention has been paid to adventitial and perivascular responses and their potential role in vascular remodeling.
Methods and Results— Balloon overstretch injury of porcine coronary arteries was performed with standard clinical angioplasty catheters. Vessels were examined from 0.5 hour to 14 days after injury by immunohistochemistry and in situ hybridization (ISH) for neutrophil and macrophage markers, cell adhesion molecules (P-selectin, E-selectin, and vascular cell adhesion molecule-1), and neutrophil-specific CXC chemokines (alveolar macrophage–derived neutrophil chemotactic factor [AMCF]-I/interleukin-8 and AMCF-II). Neutrophils accumulated in the adventitia surrounding the injury site from 2 hours to 3 days, followed by macrophages from 1 to 7 days after angioplasty. Inflammation was associated temporally with the expression of mRNAs encoding cell adhesion molecules and chemokines. The main inflammatory and proliferative foci were not limited to the adventitia but rather extended many millimeters away from the injured vessel throughout the surrounding adipose and myocardial tissues.
Conclusions— Inflammatory responses after angioplasty of porcine coronary arteries occurred throughout the entire perivascular tissue. We hypothesize that perivascular inflammatory cells play a role in the recruitment and/or proliferation of adventitial myofibroblasts, possibly through the release of reactive oxygen species and/or cytokines, and thus contribute to vascular remodeling associated with postangioplasty restenosis.
Key Words: angioplasty • inflammation • cell adhesion molecules • remodeling • restenosis
This article has been cited by other articles:
 |
|
 |
|
  M. Takaoka, D. Nagata, S. Kihara, I. Shimomura, Y. Kimura, Y. Tabata, Y. Saito, R. Nagai, and M. Sata Periadventitial Adipose Tissue Plays a Critical Role in Vascular Remodeling Circ. Res., October 23, 2009; 105(9): 906 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Fleenor and D. K. Bowles Exercise training decreases the size and alters the composition of the neointima in a porcine model of percutaneous transluminal coronary angioplasty (PTCA) J Appl Physiol, September 1, 2009; 107(3): 937 - 945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Fleenor and D. K. Bowles Negligible contribution of coronary adventitial fibroblasts to neointimal formation following balloon angioplasty in swine Am J Physiol Heart Circ Physiol, May 1, 2009; 296(5): H1532 - H1539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J Allan, J. Beattie, and D. J Flint Epithelial injury induces an innate repair mechanism linked to cellular senescence and fibrosis involving IGF-binding protein-5 J. Endocrinol., November 1, 2008; 199(2): 155 - 164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ding, S. B Kritchevsky, F.-C. Hsu, T. B Harris, G. L Burke, R. C Detrano, M. Szklo, M. H Criqui, M. Allison, P. Ouyang, et al. Association between non-subcutaneous adiposity and calcified coronary plaque: a substudy of the Multi-Ethnic Study of Atherosclerosis Am. J. Clinical Nutrition, September 1, 2008; 88(3): 645 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kido, K. Ando, M. L. Onozato, A. Tojo, M. Yoshikawa, T. Ogita, and T. Fujita Protective Effect of Dietary Potassium Against Vascular Injury in Salt-Sensitive Hypertension Hypertension, February 1, 2008; 51(2): 225 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gossl, L. O. Lerman, and A. Lerman Frontiers in Nephrology: Early Atherosclerosis A View Beyond the Lumen J. Am. Soc. Nephrol., November 1, 2007; 18(11): 2836 - 2842. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Maiellaro and W. R. Taylor The role of the adventitia in vascular inflammation Cardiovasc Res, September 1, 2007; 75(4): 640 - 648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-B. Michel, O. Thaunat, X. Houard, O. Meilhac, G. Caligiuri, and A. Nicoletti Topological Determinants and Consequences of Adventitial Responses to Arterial Wall Injury Arterioscler Thromb Vasc Biol, June 1, 2007; 27(6): 1259 - 1268. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xing, W. Feng, A. P. Miller, N. M. Weathington, Y.-F. Chen, L. Novak, J. E. Blalock, and S. Oparil Estrogen modulates TNF-{alpha}-induced inflammatory responses in rat aortic smooth muscle cells through estrogen receptor-beta activation Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2607 - H2612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. J. Wu, N. Di Girolamo, K. Beck, C. G. Hanratty, K. Choy, J. Y. Hou, M. R. Ward, and R. Stocker Probucol [4,4'-[(1-Methylethylidene)bis(thio)]bis-[2,6-bis(1,1-dimethylethyl)phenol]] Inhibits Compensatory Remodeling and Promotes Lumen Loss Associated with Atherosclerosis in Apolipoprotein E-Deficient Mice J. Pharmacol. Exp. Ther., May 1, 2007; 321(2): 477 - 484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Liu, J. Hou, X. Hu, X. Wang, Y. Xiao, Y. Mou, and H. De Leon Neuronal Chemorepellent Slit2 Inhibits Vascular Smooth Muscle Cell Migration by Suppressing Small GTPase Rac1 Activation Circ. Res., March 3, 2006; 98(4): 480 - 489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Alvarez Jr and N. K. Kapur Drug Eluting Stent Technology: A Paradigm Shift in the Treatment and Prevention of Restenosis Journal of Pharmacy Practice, December 1, 2005; 18(6): 461 - 478. [Abstract] [PDF]
|
|
|
|
|
|
E. Henrichot, C. E. Juge-Aubry, A. Pernin, J.-C. Pache, V. Velebit, J.-M. Dayer, P. Meda, C. Chizzolini, and C. A. Meier Production of Chemokines by Perivascular Adipose Tissue: A Role in the Pathogenesis of Atherosclerosis? Arterioscler Thromb Vasc Biol, December 1, 2005; 25(12): 2594 - 2599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Engeli Is there a pathophysiological role for perivascular adipocytes? Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H1794 - H1795. [Full Text] [PDF]
|
|
|
|
|
|
J. E. Barbato, B. S. Zuckerbraun, M. Overhaus, K. G. Raman, and E. Tzeng Nitric oxide modulates vascular inflammation and intimal hyperplasia in insulin resistance and the metabolic syndrome Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H228 - H236. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. Yaghini, C. Zhang, J.-H. Parmentier, A. M. Estes, N. Jafari, S. A. Schaefer, and K. U. Malik Contribution of Arachidonic Acid Metabolites Derived Via Cytochrome P4504A to Angiotensin II-Induced Neointimal Growth Hypertension, June 1, 2005; 45(6): 1182 - 1187. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Toutouzas, A. Colombo, and C. Stefanadis Inflammation and restenosis after percutaneous coronary interventions Eur. Heart J., October 1, 2004; 25(19): 1679 - 1687. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Frosen, A. Piippo, A. Paetau, M. Kangasniemi, M. Niemela, J. Hernesniemi, and J. Jaaskelainen Remodeling of Saccular Cerebral Artery Aneurysm Wall Is Associated With Rupture: Histological Analysis of 24 Unruptured and 42 Ruptured Cases Stroke, October 1, 2004; 35(10): 2287 - 2293. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Miller, W. Feng, D. Xing, N. M. Weathington, J. E. Blalock, Y.-F. Chen, and S. Oparil Estrogen Modulates Inflammatory Mediator Expression and Neutrophil Chemotaxis in Injured Arteries Circulation, September 21, 2004; 110(12): 1664 - 1669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Okada, N. Hasebe, Y. Aizawa, K. Izawa, J.-i. Kawabe, and K. Kikuchi Thermal Treatment Attenuates Neointimal Thickening With Enhanced Expression of Heat-Shock Protein 72 and Suppression of Oxidative Stress Circulation, April 13, 2004; 109(14): 1763 - 1768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kawai, K. Ando, A. Tojo, T. Shimosawa, K. Takahashi, M. L. Onozato, M. Yamasaki, T. Ogita, T. Nakaoka, and T. Fujita Endogenous Adrenomedullin Protects Against Vascular Response to Injury in Mice Circulation, March 9, 2004; 109(9): 1147 - 1153. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schillinger, W. Mlekusch, R. M. Wolfram, A. C. Budinsky, M. Exner, H. Rumpold, O. Wagner, B. Pokrajac, R. Potter, and E. Minar Endovascular Brachytherapy: Effect on Acute Inflammatory Response after Percutaneous Femoropopliteal Arterial Interventions Radiology, February 1, 2004; 230(2): 556 - 560. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Xing, A. Miller, L. Novak, R. Rocha, Y.-F. Chen, and S. Oparil Estradiol and Progestins Differentially Modulate Leukocyte Infiltration After Vascular Injury Circulation, January 20, 2004; 109(2): 234 - 241. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. Danenberg, G. Golomb, A. Groothuis, J. Gao, H. Epstein, R. V. Swaminathan, P. Seifert, and E. R. Edelman Liposomal Alendronate Inhibits Systemic Innate Immunity and Reduces In-Stent Neointimal Hyperplasia in Rabbits Circulation, December 2, 2003; 108(22): 2798 - 2804. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Bauriedel, A. Jabs, D. Skowasch, R. Hutter, J. J. Badimon, V. Fuster, U. Welsch, and B. Luderitz Dendritic cells in neointima formation after rat carotid balloon injury: coordinated expression withanti-apoptotic Bcl-2 and HSP47 in arterial repair J. Am. Coll. Cardiol., September 3, 2003; 42(5): 930 - 938. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C.M Siow, C. M Mallawaarachchi, and P. L Weissberg Migration of adventitial myofibroblasts following vascular balloon injury: insights from in vivo gene transfer to rat carotid arteries Cardiovasc Res, July 1, 2003; 59(1): 212 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Takeuchi, K. Ohmori, I. Kondo, A. Oshita, K. Shinomiya, Y. Yu, Y. Takagi, K. Mizushige, K. Kangawa, and M. Kohno Potentiation of C-type natriuretic peptide with ultrasound and microbubbles to prevent neointimal formation after vascular injury in rats Cardiovasc Res, April 1, 2003; 58(1): 231 - 238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D. Danenberg, F. G. P. Welt, M. Walker III, P. Seifert, G. S. Toegel, and E. R. Edelman Systemic Inflammation Induced by Lipopolysaccharide Increases Neointimal Formation After Balloon and Stent Injury in Rabbits Circulation, June 18, 2002; 105(24): 2917 - 2922. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Hay, C. Micko, M. F. Prescott, G. Liau, K. Robinson, and H. De Leon Differential Cell Cycle Progression Patterns of Infiltrating Leukocytes and Resident Cells After Balloon Injury of the Rat Carotid Artery Arterioscler Thromb Vasc Biol, December 1, 2001; 21(12): 1948 - 1954. [Abstract] [Full Text] [PDF]
|
|