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(Circulation. 2001;104:1978.)
© 2001 American Heart Association, Inc.

Current Perspective

High-Density Lipoproteins and Endothelial Function

Brian J. O’Connell, BA; Jacques Genest, Jr, MD

From the Cardiovascular Genetics Laboratory, McGill University Health Center, Royal Victoria Hospital, Montreal, Quebec, Canada.

Correspondence to Jacques Genest, MD, FRCP(C), Director, Division of Cardiology, McGill University Health Center/Royal Victoria Hospital, 687 Pine Ave West, Montreal, QC, Canada H3A 1A1. E-mail jacques.genest{at}muhc.mcgill.ca

Abstract— Elevated plasma levels of HDL cholesterol or apolipoprotein A-I, the major protein moiety of HDL particles, are protective against coronary artery disease. HDL particles remove cholesterol from peripheral cells and transfer it to the liver for bile acid synthesis. The interaction between lipoproteins is not mediated through simple contact between 2 phospholipid membranes but involves specific protein-receptor interactions, charged phospholipid-phospholipid contact, and activation of cellular signaling pathways. These lead to regulation of genes or the modification of proteins involved in vasomotor function, platelet activation, thrombosis and thrombolysis, cell adhesion, apoptosis and cell proliferation, and cellular cholesterol homeostasis.

Key Words: endothelium • lipoproteins • atherosclerosis

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