Circulation. 2001;104:1894-1898
doi: 10.1161/hc4101.097519
doi: 10.1161/hc4101.097519
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(Circulation. 2001;104:1894.)
© 2001 American Heart Association, Inc.
Clinical Investigation and Reports |
Selective Serotonin Reuptake Inhibitors and Myocardial Infarction
From the Cardiovascular Division (W.H.S., S.E.K.), Department of Medicine, Hospital of the University of Pennsylvania and the Center for Clinical Epidemiology and Biostatistics and Department of Biostatistics and Epidemiology (J.A.B., S.E.K.), University of Pennsylvania School of Medicine, Philadelphia, Pa.
Correspondence to Stephen E. Kimmel, MD, MS, University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, 717 Blockley Hall, 423 Guardian Dr, Philadelphia, PA 19104-6021. E-mail skimmel{at}cceb.med.upenn.edu
Background— Depression is an independent risk factor for myocardial infarction (MI). Selective serotonin reuptake inhibitors (SSRIs) may reduce this risk through attenuation of serotonin-mediated platelet activation in addition to treatment of depression itself.
Methods and Results— A case-control study of first MI in smokers 30 to 65 years of age was conducted among all 68 hospitals in an 8-county area during a 28-month period. Cases were patients hospitalized with a first MI. Approximately 4 community control subjects per case were randomly selected from the same geographic area using random digit dialing. Detailed information regarding use of antidepressant medication as well as other clinical and demographic data were obtained by telephone interview. A total of 653 cases of first MI and 2990 control subjects participated. After adjustment, using multivariable logistic regression, for age, sex, race, education, exercise, quantity smoked per day, body mass index, aspirin use, family history of MI, number of physician encounters, and history of coronary disease, diabetes, hypertension, or hypercholesterolemia, the odds ratio for MI among current SSRI users compared with nonusers was 0.35 (95% CI 0.18, 0.68; P<0.01). Non-SSRI antidepressant users had a nonsignificant reduction in MI risk with wide confidence intervals (adjusted odds ratio 0.48, CI 0.17, 1.32; P=0.15). However, analysis of this group was limited by the small number of exposed subjects.
Conclusions— The use of SSRIs may confer a protective effect against MI. This could be attributable to the inhibitory effect SSRIs have on serotonin-mediated platelet activation or possibly amelioration of other factors associated with increased risk for MI in depression.
Key Words: serotonin uptake inhibitors • depression • epidemiology • myocardial infarction • drugs • platelets
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|
|
|
|
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|
|
|
|
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|
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|
|
|
|
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|
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|
|
|
|
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|
|
|
|
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|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
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|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
B. Ruo, J. S. Rumsfeld, M. A. Hlatky, H. Liu, W. S. Browner, and M. A. Whooley Depressive Symptoms and Health-Related Quality of Life: The Heart and Soul Study JAMA, July 9, 2003; 290(2): 215 - 221. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. H. Sauer, J. A. Berlin, and S. E. Kimmel Effect of Antidepressants and Their Relative Affinity for the Serotonin Transporter on the Risk of Myocardial Infarction Circulation, July 8, 2003; 108(1): 32 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
Writing Committee for the ENRICHD Investigators Effects of Treating Depression and Low Perceived Social Support on Clinical Events After Myocardial Infarction: The Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial JAMA, June 18, 2003; 289(23): 3106 - 3116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Danner, S. V. Kasl, J. L. Abramson, and V. Vaccarino Association Between Depression and Elevated C-Reactive Protein Psychosom Med, May 1, 2003; 65(3): 347 - 356. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
F. Fumeron, D. Betoulle, V. Nicaud, A. Evans, F. Kee, J.-B. Ruidavets, D. Arveiler, G. Luc, and F. Cambien Serotonin Transporter Gene Polymorphism and Myocardial Infarction: Etude Cas-Temoins de l'Infarctus du Myocarde (ECTIM) Circulation, June 25, 2002; 105(25): 2943 - 2945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
P. Pacher and Z. Ungvari Use of Selective Serotonin Reuptake Inhibitors and Myocardial Infarction Circulation, April 9, 2002; 105 (14): e84 - e84. [Full Text] [PDF]
|
|
|
|
 |
|
 SSRIs May Protect Against Myocardial Infarction Journal Watch Psychiatry, March 6, 2002; 2002(306): 3 - 3. [Full Text]
|
|