(Circulation. 2001;103:820.)
© 2001 American Heart Association, Inc.
Clinical Investigation and Reports |
Relations of Stroke Volume and Cardiac Output to Body Composition
The Strong Heart Study
From Cornell Medical Center, New York, NY (T.C., R.B.D., M.J.R., G.d.S.); University of Oklahoma Health Sciences Center, Oklahoma City (J.-L.Y.); MedStar Research Institute, Washington, DC (B.V.H.); National Heart, Lung, and Blood Institute, Bethesda, Md (R.R.F.); and Aberdeen Area Tribal Chairmen’s Health Board, Rapid City, SD (T.K.W.).
Correspondence to Richard B. Devereux, MD, Division of Cardiology, Box 222, Cornell Medical Center, 525 E 68th St, New York, NY 10021. E-mail rbdevere{at}med.cornell.edu
Background—Although cardiac output (CO) plays the vital role of delivering nutrients to body tissues, few data are available concerning the relations of stroke volume (SV) and CO to body composition in large population samples.
Methods and
Results—Doppler and 2D echocardiography and
bioelectric impedance in 2744 Strong Heart Study participants were used
to calculate SV and CO and to relate them to fat-free body mass (FFM),
adipose mass, and demographic variables. Both SV and CO were higher in
men than women and in overweight than normal-weight individuals, but
these differences were diminished or even reversed by normalization for
FFM or body surface area. In both sexes, SV and CO were more strongly
related to FFM than adipose mass, other body habitus measures, arterial
pressure, diabetes, or age. In multivariate analyses using the average
of Doppler and left ventricular SV to minimize measurement variability,
FFM was the strongest correlate of SV and CO; other independent
correlates were adipose mass, systolic pressure, diabetes, age, and use
of digoxin and calcium channel and
-blockers.
Conclusions—In a population-based sample, SV and CO are more strongly related to FFM than other variables; increased FFM may be the primary determinant of increased SV and CO in obesity.
Key Words: American Indians • diabetes mellitus • echocardiography • ventricles
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