Donate Help Contact The AHA Sign In Home
American Heart Association
Circulation
Search: search_blue_button Advanced Search
Circulation. 2001;103:820-825

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Collis, T.
Right arrow Articles by Welty, T. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Collis, T.
Right arrow Articles by Welty, T. K.
Related Collections
Right arrow Obesity
Right arrow Epidemiology

(Circulation. 2001;103:820.)
© 2001 American Heart Association, Inc.


Clinical Investigation and Reports

Relations of Stroke Volume and Cardiac Output to Body Composition

The Strong Heart Study

Tarquin Collis, MD; Richard B. Devereux, MD; Mary J. Roman, MD; Giovanii de Simone, MD; Jeun-Liang Yeh, PhD; Barbara V. Howard, PhD; Richard R. Fabsitz, MA; Thomas K. Welty, MD

From Cornell Medical Center, New York, NY (T.C., R.B.D., M.J.R., G.d.S.); University of Oklahoma Health Sciences Center, Oklahoma City (J.-L.Y.); MedStar Research Institute, Washington, DC (B.V.H.); National Heart, Lung, and Blood Institute, Bethesda, Md (R.R.F.); and Aberdeen Area Tribal Chairmen’s Health Board, Rapid City, SD (T.K.W.).

Correspondence to Richard B. Devereux, MD, Division of Cardiology, Box 222, Cornell Medical Center, 525 E 68th St, New York, NY 10021. E-mail rbdevere{at}med.cornell.edu

Background—Although cardiac output (CO) plays the vital role of delivering nutrients to body tissues, few data are available concerning the relations of stroke volume (SV) and CO to body composition in large population samples.

Methods and Results—Doppler and 2D echocardiography and bioelectric impedance in 2744 Strong Heart Study participants were used to calculate SV and CO and to relate them to fat-free body mass (FFM), adipose mass, and demographic variables. Both SV and CO were higher in men than women and in overweight than normal-weight individuals, but these differences were diminished or even reversed by normalization for FFM or body surface area. In both sexes, SV and CO were more strongly related to FFM than adipose mass, other body habitus measures, arterial pressure, diabetes, or age. In multivariate analyses using the average of Doppler and left ventricular SV to minimize measurement variability, FFM was the strongest correlate of SV and CO; other independent correlates were adipose mass, systolic pressure, diabetes, age, and use of digoxin and calcium channel and {beta}-blockers.

Conclusions—In a population-based sample, SV and CO are more strongly related to FFM than other variables; increased FFM may be the primary determinant of increased SV and CO in obesity.


Key Words: American Indians • diabetes mellitus • echocardiography • ventricles




This article has been cited by other articles:


Home page
Obstet GynecolHome page
C. De Paco, N. Kametas, G. Rencoret, I. Strobl, and K. H. Nicolaides
Maternal Cardiac Output Between 11 and 13 Weeks of Gestation in the Prediction of Preeclampsia and Small for Gestational Age
Obstet. Gynecol., February 1, 2008; 111(2): 292 - 300.
[Abstract] [Full Text] [PDF]


Home page
J. Nutr.Home page
S. Eilat-Adar, J. Xu, C. Loria, C. Mattil, U. Goldbourt, B. V. Howard, and H. E. Resnick
Dietary Calcium Is Associated with Body Mass Index and Body Fat in American Indians
J. Nutr., August 1, 2007; 137(8): 1955 - 1960.
[Abstract] [Full Text] [PDF]


Home page
Arterioscler. Thromb. Vasc. Bio.Home page
P. Poirier, T. D. Giles, G. A. Bray, Y. Hong, J. S. Stern, F. X. Pi-Sunyer, and R. H. Eckel
Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss.
Arterioscler. Thromb. Vasc. Biol., May 1, 2006; 26(5): 968 - 976.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
P. Poirier, T. D. Giles, G. A. Bray, Y. Hong, J. S. Stern, F. X. Pi-Sunyer, and R. H. Eckel
Obesity and Cardiovascular Disease: Pathophysiology, Evaluation, and Effect of Weight Loss: An Update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease From the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism
Circulation, February 14, 2006; 113(6): 898 - 918.
[Abstract] [Full Text] [PDF]


Home page
Anesth. Analg.Home page
F. X. Whalen, O. Gajic, G. B. Thompson, M. L. Kendrick, F. L. Que, B. A. Williams, M. J. Joyner, R. D. Hubmayr, D. O. Warner, and J. Sprung
The Effects of the Alveolar Recruitment Maneuver and Positive End-Expiratory Pressure on Arterial Oxygenation During Laparoscopic Bariatric Surgery
Anesth. Analg., January 1, 2006; 102(1): 298 - 305.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Physiol. Heart Circ. Physiol.Home page
P. D. Chantler, R. E. Clements, L. Sharp, K. P. George, L.-B. Tan, and D. F. Goldspink
The influence of body size on measurements of overall cardiac function
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2059 - H2065.
[Abstract] [Full Text] [PDF]


Home page
CirculationHome page
G. de Simone, K. Wachtell, V. Palmieri, D. A. Hille, G. Beevers, B. Dahlof, U. de Faire, F. Fyhrquist, H. Ibsen, S. Julius, et al.
Body Build and Risk of Cardiovascular Events in Hypertension and Left Ventricular Hypertrophy: The LIFE (Losartan Intervention For Endpoint reduction in hypertension) Study
Circulation, April 19, 2005; 111(15): 1924 - 1931.
[Abstract] [Full Text] [PDF]


Home page
Am. J. Clin. Nutr.Home page
G. de Simone, R. B Devereux, J. R Kizer, M. Chinali, J. N Bella, A. Oberman, D. W Kitzman, P. N Hopkins, D. Rao, and D. K Arnett
Body composition and fat distribution influence systemic hemodynamics in the absence of obesity: the HyperGEN Study
Am. J. Clinical Nutrition, April 1, 2005; 81(4): 757 - 761.
[Abstract] [Full Text] [PDF]


Home page
J Am Coll CardiolHome page
G. A. Whalley and R. N. Doughty
Definition of physiological hypertrophy in ultramarathon athletes
J. Am. Coll. Cardiol., July 21, 2004; 44(2): 469 - 469.
[Full Text] [PDF]