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(Circulation. 2000;102:748.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Randomized Comparison of Antiarrhythmic Drug Therapy With Implantable Defibrillators in Patients Resuscitated From Cardiac Arrest
The Cardiac Arrest Study Hamburg (CASH)
From St Georg Hospital, Hamburg, Germany.
Correspondence to Karl-Heinz Kuck, MD, AK St Georg, Lohmühlenstrasse 5, 20099 Hamburg, Germany. E-mail kuck{at}uke.uni-hamburg.de
Background—We conducted a prospective, multicenter, randomized comparison of implantable cardioverter-defibrillator (ICD) versus antiarrhythmic drug therapy in survivors of cardiac arrest secondary to documented ventricular arrhythmias.
Methods and Results—From 1987, eligible patients were randomized to an ICD, amiodarone, propafenone, or metoprolol (ICD versus antiarrhythmic agents randomization ratio 1:3). Assignment to propafenone was discontinued in March 1992, after an interim analysis conducted in 58 patients showed a 61% higher all-cause mortality rate than in 61 ICD patients during a follow-up of 11.3 months. The study continued to recruit 288 patients in the remaining 3 study groups; of these, 99 were assigned to ICDs, 92 to amiodarone, and 97 to metoprolol. The primary end point was all-cause mortality. The study was terminated in March 1998, when all patients had concluded a minimum 2-year follow-up. Over a mean follow-up of 57±34 months, the crude death rates were 36.4% (95% CI 26.9% to 46.6%) in the ICD and 44.4% (95% CI 37.2% to 51.8%) in the amiodarone/metoprolol arm. Overall survival was higher, though not significantly, in patients assigned to ICD than in those assigned to drug therapy (1-sided P=0.081, hazard ratio 0.766, [97.5% CI upper bound 1.112]). In ICD patients, the percent reductions in all-cause mortality were 41.9%, 39.3%, 28.4%, 27.7%, 22.8%, 11.4%, 9.1%, 10.6%, and 24.7% at years 1 to 9 of follow-up.
Conclusions—During long-term follow-up of cardiac arrest survivors, therapy with an ICD is associated with a 23% (nonsignificant) reduction of all-cause mortality rates when compared with treatment with amiodarone/metoprolol. The benefit of ICD therapy is more evident during the first 5 years after the index event.
Key Words: heart arrest • defibrillation • cardioversion • antiarrhythmia agents • resuscitation
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|
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|
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|
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|
|
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|
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|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
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|
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|
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|
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|
|
|
|
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|
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|
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|
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|
|
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|
|
|
|
|
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|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
K.-H. Kuck and S. Nisam ICD therapy: 'the sickest benefit the most...': what about the less sick? Europace, July 1, 2006; 8(7): 508 - 511. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Nisam and G. Breithardt Lessons learned from neutral ICD trials Europace, June 1, 2006; 8(6): 393 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Goldberger and R. Lampert Implantable Cardioverter-Defibrillators: Expanding Indications and Technologies JAMA, February 15, 2006; 295(7): 809 - 818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Paisey, A. M. Yue, F. Bessoule, P. R. Roberts, and J. M. Morgan Passive electrode effect reduces defibrillation threshold in bi-filament middle cardiac vein defibrillation. Europace, February 1, 2006; 8(2): 113 - 117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M C S Hall and D M Todd Modern management of arrhythmias Postgrad. Med. J., February 1, 2006; 82(964): 117 - 125. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Abello, J. L. Merino, R. Peinado, M. Gnoatto, M. A. Arias, M. Gonzalez-Vasserot, and J. A. Sobrino Syncope following cardioverter defibrillator implantation in patients with spontaneous syncopal monomorphic ventricular tachycardia Eur. Heart J., January 1, 2006; 27(1): 89 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Part 4: Advanced Life Support Circulation, November 29, 2005; 112(22_suppl): III-25 - III-54. [Full Text] [PDF]
|
|
|
|
|
|
A. Elhendy, S. Chapman, T. R. Porter, and J. Windle Association of Myocardial Ischemia With Mortality and Implantable Cardioverter-Defibrillator Therapy in Patients With Coronary Artery Disease at Risk of Arrhythmic Death J. Am. Coll. Cardiol., November 1, 2005; 46(9): 1721 - 1726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Al-Khatib, F. L. Lucas, J. G. Jollis, D. J. Malenka, and D. E. Wennberg The Relation Between Patients' Outcomes and the Volume of Cardioverter-Defibrillator Implantation Procedures Performed by Physicians Treating Medicare Beneficiaries J. Am. Coll. Cardiol., October 18, 2005; 46(8): 1536 - 1540. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. G. Manios, E. M. Kallergis, E. M. Kanoupakis, H. E. Mavrakis, D. C. Kambouraki, D. A. Arfanakis, and P. E. Vardas Amino-Terminal Pro-Brain Natriuretic Peptide Predicts Ventricular Arrhythmogenesis in Patients With Ischemic Cardiomyopathy and Implantable Cardioverter-Defibrillators Chest, October 1, 2005; 128(4): 2604 - 2610. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gehi, D. Haas, and V. Fuster Primary Prophylaxis With the Implantable Cardioverter-Defibrillator: The Need for Improved Risk Stratification JAMA, August 24, 2005; 294(8): 958 - 960. [Full Text] [PDF]
|
|
|
|
|
|
A. Kadish and M. Mehra Heart Failure Devices: Implantable Cardioverter-Defibrillators and Biventricular Pacing Therapy Circulation, June 21, 2005; 111(24): 3327 - 3335. [Full Text] [PDF]
|
|
|
|
|
|
M. O. Sweeney, M. S. Wathen, K. Volosin, I. Abdalla, P. J. DeGroot, M. F. Otterness, and A. J. Stark Appropriate and Inappropriate Ventricular Therapies, Quality of Life, and Mortality Among Primary and Secondary Prevention Implantable Cardioverter Defibrillator Patients: Results From the Pacing Fast VT REduces Shock ThErapies (PainFREE Rx II) Trial Circulation, June 7, 2005; 111(22): 2898 - 2905. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Buxton, A. J. Moss, A. E. Buxton, and A. J. Moss Should everyone with an ejection fraction less than or equal to 30% receive an implantable cardioverter-defibrillator? Circulation, May 17, 2005; 111(19): 2537 - 2549. [Full Text] [PDF]
|
|
|
|
|
|
P. S. Chan and R. A. Hayward Mortality Reduction by Implantable Cardioverter-Defibrillators in High-Risk Patients With Heart Failure, Ischemic Heart Disease, and New-Onset Ventricular Arrhythmia: An Effectiveness Study J. Am. Coll. Cardiol., May 3, 2005; 45(9): 1474 - 1481. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sukhija, W. S. Aronow, C. Sorbera, K. Yalamanchili, and M. Cohen Patients, Mean Age 70 Years, With Automatic Implantable Cardioverter-Defibrillators Treated With Dual-Chamber Rate Responsive Pacing (DDDR-70) Have a Higher Mortality Than Patients With Backup Ventricular Pacing (VVI-40) at 3.7-Year Follow-Up J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2005; 60(5): 603 - 604. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A Y Patwala and D J Wright Device based treatment of heart failure Postgrad. Med. J., May 1, 2005; 81(955): 286 - 291. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. S Spector Diagnosis and management of sudden cardiac death Heart, March 1, 2005; 91(3): 408 - 413. [Full Text] [PDF]
|
|
|
|
|
|
P. W. Groeneveld, P. A. Heidenreich, and A. M. Garber Trends in implantable cardioverter-defibrillator racial disparity: The importance of geography J. Am. Coll. Cardiol., January 4, 2005; 45(1): 72 - 78. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Plummer, R. J. Irving, and J. M. McComb The incidence of implantable cardioverter defibrillator indications in patients admitted to all coronary care units in a single district Europace, January 1, 2005; 7(3): 266 - 272. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Hlatky, G. D. Sanders, and D. K. Owens Evidence-Based Medicine And Policy: The Case Of The Implantable Cardioverter Defibrillator Health Aff., January 1, 2005; 24(1): 42 - 51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. S. Desai, J. C. Fang, W. H. Maisel, and K. L. Baughman Implantable Defibrillators for the Prevention of Mortality in Patients With Nonischemic Cardiomyopathy: A Meta-analysis of Randomized Controlled Trials JAMA, December 15, 2004; 292(23): 2874 - 2879. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Parkash, A. Tang, G. Wells, J. Blackburn, I. Stiell, C. Simpson, P. Dorian, R. Yee, D. Cameron, S. Connolly, et al. Use of implantable cardioverter defibrillators after out-of-hospital cardiac arrest: a prospective follow-up study Can. Med. Assoc. J., October 26, 2004; 171(9): 1053 - 1056. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. J.J. Wellens Cardiac arrhythmias: The quest for a cure: A historical perspective J. Am. Coll. Cardiol., September 15, 2004; 44(6): 1155 - 1163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Voigt, R. Ezzeddine, W. Barrington, O. Obiaha-Ngwu, L. I. Ganz, B. London, and S. Saba Utilization of implantable cardioverter-defibrillators in survivors of cardiac arrest in the United States from 1996 to 2001 J. Am. Coll. Cardiol., August 18, 2004; 44(4): 855 - 858. [Abstract] [Full Text] [PDF]
|
|