(Circulation. 2000;102:506.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Noninvasive In Vivo Human Coronary Artery Lumen and Wall Imaging Using Black-Blood Magnetic Resonance Imaging
From the Zena and Michael A. Wiener Cardiovascular Institute (Z.A.F., V.F., J.T.F., T.J., S.G.W., G.H., J.G.A., J.J.B., S.S.) and the Departments of Radiology (Z.A.F.), Medicine (V.F., J.T.F., J.J.B., S.S.), and Pathology (J.T.F.), Mount Sinai School of Medicine, New York, NY.
Correspondence to Zahi A. Fayad, PhD, Mount Sinai School of Medicine, Box 1234, New York, NY 10029. E-mail zahi.fayad{at}mssm.edu
Background—High-resolution MRI has the potential to noninvasively image the human coronary artery wall and define the degree and nature of coronary artery disease. Coronary artery imaging by MR has been limited by artifacts related to blood flow and motion and by low spatial resolution.
Methods and Results—We used a noninvasive black-blood (BB) MRI
(BB-MR) method, free of motion and blood-flow artifacts, for
high-resolution (down to 0.46 mm in-plane resolution and 3-mm
slice thickness) imaging of the coronary artery lumen and wall.
In vivo BB-MR of both normal and atherosclerotic human coronary
arteries was performed in 13 subjects: 8 normal subjects and 5 patients
with coronary artery disease. The average coronary wall
thickness for each cross-sectional image was 0.75±0.17 mm (range,
0.55 to 1.0 mm) in the normal subjects. MR images of
coronary arteries in patients with 
40% stenosis as
assessed by x-ray angiography showed localized wall thickness of
4.38±0.71 mm (range, 3.30 to 5.73 mm). The difference in
maximum wall thickness between the normal subjects and patients was
statistically significant (P<0.0001).
Conclusions—In vivo high-spatial-resolution BB-MR provides a unique new method to noninvasively image and assess the morphological features of human coronary arteries. This may allow the identification of atherosclerotic disease before it is symptomatic. Further studies are necessary to identify the different plaque components and to assess lesions in asymptomatic patients and their outcomes.
Key Words: atherosclerosis • magnetic resonance imaging • coronary disease
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