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(Circulation. 2000;102:494.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Moderate Alcohol Consumption and Risk of Coronary Heart Disease Among Women With Type 2 Diabetes Mellitus
From the Division of Women’s Health (C.G.S.), Channing Laboratory (F.B.H., M.J.S., G.A.C., F.E.S., E.B.R., W.C.W., J.E.M.), Division of Preventive Medicine (J.E.M.), Department of Medicine, Brigham and Women’s Hospital and the Departments of Nutrition (F.B.H., M.J.S., E.B.R., W.C.W.) and Epidemiology (M.J.S., G.A.C., E.B.R., W.C.W., J.E.M.), Harvard School of Public Health, Boston, Mass.
Correspondence to Caren G. Solomon, Division of Women’s Health, Brigham and Women’s Hospital, 75 Francis St, Boston, MA 02115. E-mail cgsolomon{at}bics.bwh.harvard.edu
Background—Moderate alcohol consumption is associated with reduced risk for coronary heart disease (CHD) in generally healthy populations. We assessed prospectively the association between moderate alcohol intake and CHD risk in women with type 2 diabetes mellitus, a group at high risk for cardiovascular disease.
Methods and Results—We studied women in the Nurses’ Health Study
who reported a diagnosis of diabetes mellitus at 
30 years of age.
During 39 092 person-years of follow-up from 1980 to 1994, there were
295 CHD events documented among this population, including 194 cases of
nonfatal myocardial infarction and 101 cases of fatal CHD. Odds ratios
derived from logistic regression were used to estimate relative risks
(RRs) for CHD as a function of usual alcohol intake, with adjustment
for potential confounders. Compared with diabetic women reporting no
alcohol intake, the age-adjusted RR for nonfatal or fatal CHD among
diabetic women reporting usual intake of 0.1 to 4.9 g (<0.5
drinks) of alcohol daily was 0.74 (95% CI 0.56 to 0.98), and among
those reporting usual intake 5 g/d, it was 0.48 (95% CI 0.32 to
0.72) (P for trend <0.0001). Inverse associations
between alcohol intake and CHD risk remained significant in
multivariate analysis adjusting for several
other coronary risk factors (0.1 to 4.9 g/d: RR 0.72 [95% CI
0.54 to 0.96]; 5 g/d: RR 0.45 [0.29 to 0.68]).
Conclusions—Although potential risks of alcohol consumption must be considered, these data suggest that moderate alcohol consumption is associated with reduced CHD risk in women with diabetes and should not be routinely discouraged.
Key Words: diabetes mellitus • coronary disease • alcohol • risk factors
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