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(Circulation. 2000;102:3092.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Alcohol Consumption and Risk of Intermittent Claudication in the Framingham Heart Study
From the Department of Medicine, Section of Preventive Medicine & Epidemiology (L.D., D.L., J.M.M., R.C.E.), Boston University School of Medicine, Boston, Mass; the Framingham Heart Study/NHLBI (D.L., J.M.M.), Framingham, Mass; the Section of General Internal Medicine (J.M.M.), Boston University School of Medicine, Boston, Mass; and the Department of Epidemiology and Biostatistics (L.A.C.), Boston University School of Public Health, Boston, Mass.
Correspondence to Luc Djoussé, MD, MPH, Boston University School of Medicine, Section of Preventive Medicine & Epidemiology, Department of Medicine, 715 Albany St, Room B-612, Boston, MA 02118-2526. E-mail: ldjousse{at}bu.edu
Background—Intermittent claudication (IC) is associated with an increased risk of cardiovascular disease morbidity and mortality. The relation of alcohol consumption to the risk of IC remains controversial. The purpose of this study was to assess the relation of alcohol consumption and type of beverage to the development of IC among participants in the Framingham Heart Study.
Methods and
Results—Alcohol consumption was categorized as
0, 1 to 6, 7 to 12, 13 to 24, and 
25 g/d. During a mean follow-up of
6.8 years, 414 subjects developed IC. From the lowest to the highest
category of alcohol intake, the age-standardized incidence rates of IC
were 5.3, 4.1, 4.2, 3.2, and 4.6 cases/1000 person-years for men and
3.4, 2.5, 1.5, 1.9, and 2.5, respectively, for women. A
multivariate Cox regression model demonstrated an
inverse relation, with the lowest IC risk at levels of 13 to 24 g/d for
men and 7 to 12 g/d for women compared with nondrinkers; the hazard
ratio (95% CI) was 0.67 (0.42 to 0.99) for men and 0.44 (0.23 to 0.80)
for women. This protective effect was seen mostly with wine and beer
consumption.
Conclusions—Our data are consistent with a protective effect of moderate alcohol consumption on IC risk, with lowest risk observed in men consuming 13 to 24 g/d (1 to 2 drinks/d) and in women consuming 7 to 12 g/d (0.5 to 1 drink/d).
Key Words: alcohol • smoking • peripheral vascular disease
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