(Circulation. 2000;102:3053.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
From the Division of Cardiology, Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Md. Dr Spinelli is now at Guidant, St. Paul, Minn.
Correspondence to David A. Kass, MD, Halsted 500, The Johns Hopkins Hospital, 600 N. Wolfe St, Baltimore, MD 21287. E-mail dkass{at}bme.jhu.edu
BackgroundLeft ventricular or biventricular pacing/stimulation can acutely improve systolic function in patients with dilated cardiomyopathy (DCM) and intraventricular conduction delay by resynchronizing contraction. Most heart failure therapies directly enhancing systolic function do so while concomitantly increasing myocardial oxygen consumption (MVO2). We hypothesized that pacing/stimulation, in contrast, incurs systolic benefits without raising energy demand.
Methods and ResultsTen
DCM patients with left bundle-branch block (ejection fraction 20±3%,
QRS duration179±3 ms, mean±SEM) underwent cardiac
catheterization to measure ventricular and
aortic pressure, coronary blood flow,
arterialcoronary sinus oxygen difference
(
AVO2), and
M
O2. Data were measured under sinus
rhythm or with left ventricular or
biventricular pacing/stimulation at the same heart rate.
These results were then contrasted to intravenous
dobutamine (n=7) titrated to match systolic changes
during LV pacing. Systolic function rose quickly and
substantially from LV pacing (18±4% rise in arterial
pulse pressure, which correlates with cardiac output, and 43±6%
increase in dP/dtmax; both
P<0.01). However,
AVO2 and M
O2
declined -4±2% and -8±6.5%, respectively (both
P<0.05). Similar results were
obtained with biventricular activation. In contrast,
dobutamine raised dP/dtmax 37±6%,
accompanied by a 22±11% rise in per-beat
M
O2
(P<0.05 versus
pacing).
ConclusionsVentricular resynchronization by left ventricular or biventricular pacing/stimulation in DCM patients with left bundle-branch block acutely enhances systolic function while modestly lowering energy cost. This should prove valuable for treating DCM patients with basal dyssynchrony.
Key Words: heart failure bundle-branch block pacing oxygen
This article has been cited by other articles:
![]() |
I. Koniari eComment: Biventricular pacing improves cardiac function compared to univenticular pacing alone in postoperative patients Interactive CardioVascular and Thoracic Surgery, June 1, 2009; 8(6): 678 - 679. [Full Text] [PDF] |
||||
![]() |
J. Janousek Cardiac resynchronisation in congenital heart disease Heart, June 1, 2009; 95(11): 940 - 947. [Full Text] [PDF] |
||||
![]() |
S. A. Hunt, W. T. Abraham, M. H. Chin, A. M. Feldman, G. S. Francis, T. G. Ganiats, M. Jessup, M. A. Konstam, D. M. Mancini, K. Michl, et al. 2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation J. Am. Coll. Cardiol., April 14, 2009; 53(15): e1 - e90. [Full Text] [PDF] |
||||
![]() |
M. Jessup, W. T. Abraham, D. E. Casey, A. M. Feldman, G. S. Francis, T. G. Ganiats, M. A. Konstam, D. M. Mancini, P. S. Rahko, M. A. Silver, et al. 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines Developed in Collaboration With the International Society for Heart and Lung Transplantation J. Am. Coll. Cardiol., April 14, 2009; 53(15): 1343 - 1382. [Full Text] [PDF] |
||||
![]() |
2009 WRITING GROUP TO REVIEW NEW EVIDENCE AND UPDA, M. Jessup, W. T. Abraham, D. E. Casey, A. M. Feldman, G. S. Francis, T. G. Ganiats, M. A. Konstam, D. M. Mancini, P. S. Rahko, et al. 2009 Focused Update: ACCF/AHA Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the International Society for Heart and Lung Transplantation Circulation, April 14, 2009; 119(14): 1977 - 2016. [Full Text] [PDF] |
||||
![]() |
2005 WRITING COMMITTEE MEMBERS, S. A. Hunt, W. T. Abraham, M. H. Chin, A. M. Feldman, G. S. Francis, T. G. Ganiats, M. Jessup, M. A. Konstam, D. M. Mancini, et al. 2009 Focused Update Incorporated Into the ACC/AHA 2005 Guidelines for the Diagnosis and Management of Heart Failure in Adults: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: Developed in Collaboration With the International Society for Heart and Lung Transplantation Circulation, April 14, 2009; 119(14): e391 - e479. [Full Text] [PDF] |
||||
![]() |
C. Parsai, B. Bijnens, G. R. Sutherland, A. Baltabaeva, P. Claus, M. Marciniak, V. Paul, M. Scheffer, E. Donal, G. Derumeaux, et al. Toward understanding response to cardiac resynchronization therapy: left ventricular dyssynchrony is only one of multiple mechanisms Eur. Heart J., April 2, 2009; 30(8): 940 - 949. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-U. Voigt, T.-M. Schneider, S. Korder, M. Szulik, E. Gurel, W. G. Daniel, F. Rademakers, and F. A. Flachskampf Apical transverse motion as surrogate parameter to determine regional left ventricular function inhomogeneities: a new, integrative approach to left ventricular asynchrony assessment Eur. Heart J., April 2, 2009; 30(8): 959 - 968. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. P. H.M. Delnoy, J. P. Ottervanger, H. O. Luttikhuis, D. H.S. Vos, A. Elvan, A. R. Ramdat Misier, W. P. Beukema, P. Steendijk, and N. M. van Hemel Pressure-volume loop analysis during implantation of biventricular pacemaker/cardiac resynchronization therapy device to optimize right and left ventricular pacing sites Eur. Heart J., April 1, 2009; 30(7): 797 - 804. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Chakir, S. K. Daya, T. Aiba, R. S. Tunin, V. L. Dimaano, T. P. Abraham, K. Jaques, E. W. Lai, K. Pacak, W.-Z. Zhu, et al. Mechanisms of Enhanced {beta}-Adrenergic Reserve From Cardiac Resynchronization Therapy Circulation, March 10, 2009; 119(9): 1231 - 1240. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Vanderheyden and J. Bartunek Cardiac Resynchronization Therapy in Dyssynchronous Heart Failure: Zooming in on Cellular and Molecular Mechanisms Circulation, March 10, 2009; 119(9): 1192 - 1194. [Full Text] [PDF] |
||||
![]() |
W. Mullens, T. Verga, R. A. Grimm, R. C. Starling, B. L. Wilkoff, and W.H. W. Tang Persistent hemodynamic benefits of cardiac resynchronization therapy with disease progression in advanced heart failure. J. Am. Coll. Cardiol., February 17, 2009; 53(7): 600 - 607. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Ukkonen, J. Sundell, and J. Knuuti Effects of CRT on myocardial innervation, perfusion and metabolism Europace, November 1, 2008; 10(suppl_3): iii114 - iii117. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. G. J. Gademan, R. J. van Bommel, C. Ypenburg, J. C. W. Haest, M. J. Schalij, E. E. van der Wall, J. J. Bax, and C. A. Swenne Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex Am J Physiol Heart Circ Physiol, August 1, 2008; 295(2): H755 - H760. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. C. Wang, A. P. Maggioni, M. A. Konstam, F. Zannad, H. B. Krasa, J. C. Burnett Jr, L. Grinfeld, K. Swedberg, J. E. Udelson, T. Cook, et al. Clinical Implications of QRS Duration in Patients Hospitalized With Worsening Heart Failure and Reduced Left Ventricular Ejection Fraction JAMA, June 11, 2008; 299(22): 2656 - 2666. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. O. Sweeney and F. W. Prinzen Ventricular Pump Function and Pacing: Physiological and Clinical Integration Circ Arrhythmia Electrophysiol, June 1, 2008; 1(2): 127 - 139. [Full Text] [PDF] |
||||
![]() |
C. Valzania, F. Gadler, R. Winter, F. Braunschweig, L.-A. Brodin, P. Gudmundsson, G. Boriani, and M. J. Eriksson Effects of cardiac resynchronization therapy on coronary blood flow: Evaluation by transthoracic Doppler echocardiography Eur J Heart Fail, May 1, 2008; 10(5): 514 - 520. [Abstract] [Full Text] [PDF] |
||||
![]() |
K. Chakir, S. K. Daya, R. S. Tunin, R. H. Helm, M. J. Byrne, V. L. Dimaano, A. C. Lardo, T. P. Abraham, G. F. Tomaselli, and D. A. Kass Reversal of Global Apoptosis and Regional Stress Kinase Activation by Cardiac Resynchronization Circulation, March 18, 2008; 117(11): 1369 - 1377. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Milliez, O. Thomas, A. Haggui, P. Schurando, P. Squara, A. Cohen-Solal, A. Mebazaa, and A. Leenhardt Cardiac resynchronisation as a rescue therapy in patients with catecholamine-dependent overt heart failure: Results from a short and mid-term study Eur J Heart Fail, March 1, 2008; 10(3): 291 - 297. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Vanderheyden, W. Mullens, L. Delrue, M. Goethals, B. de Bruyne, W. Wijns, P. Geelen, S. Verstreken, F. Wellens, and J. Bartunek Myocardial Gene Expression in Heart Failure Patients Treated With Cardiac Resynchronization Therapy: Responders Versus Nonresponders J. Am. Coll. Cardiol., January 15, 2008; 51(2): 129 - 136. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Stockburger, S. Fateh-Moghadam, A. Nitardy, O. Celebi, A. Krebs, D. Habedank, and R. Dietz Baseline Doppler parameters are useful predictors of chronic left ventricular reduction in size by cardiac resynchronization therapy Europace, January 1, 2008; 10(1): 69 - 74. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Butter and G. Hindricks Cardiac resynchronization therapy: haemodynamic background and perspectives Eur. Heart J. Suppl., December 1, 2007; 9(suppl_I): I87 - I93. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Sirker, M. Thomas, S. Baker, J. Shrimpton, S. Jewell, L. Lee, R. Rankin, V. Griffiths, N. Cooter, R. James, et al. Cardiac resynchronization therapy: left or left-and-right for optimal symptomatic effect the LOLA ROSE study Europace, October 1, 2007; 9(10): 862 - 868. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Ashrafian, M. P. Frenneaux, and L. H. Opie Metabolic Mechanisms in Heart Failure Circulation, July 24, 2007; 116(4): 434 - 448. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Valzania, F. Gadler, M. J. Eriksson, A. Olsson, G. Boriani, and F. Braunschweig Electromechanical effects of cardiac resynchronization therapy during rest and stress in patients with heart failure Eur J Heart Fail, June 1, 2007; 9(6-7): 644 - 650. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Imai, S. Rastogi, R. C. Gupta, S. Mishra, V. G. Sharov, W. C. Stanley, Y. Mika, B. Rousso, D. Burkhoff, S. Ben-Haim, et al. Therapy With Cardiac Contractility Modulation Electrical Signals Improves Left Ventricular Function and Remodeling in Dogs With Chronic Heart Failure J. Am. Coll. Cardiol., May 29, 2007; 49(21): 2120 - 2128. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. H. Helm, M. Byrne, P. A. Helm, S. K. Daya, N. F. Osman, R. Tunin, H. R. Halperin, R. D. Berger, D. A. Kass, and A. C. Lardo Three-Dimensional Mapping of Optimal Left Ventricular Pacing Site for Cardiac Resynchronization Circulation, February 27, 2007; 115(8): 953 - 961. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Knaapen, T. Germans, J. Knuuti, W. J. Paulus, P. A. Dijkmans, C. P. Allaart, A. A. Lammertsma, and F. C. Visser Myocardial Energetics and Efficiency: Current Status of the Noninvasive Approach Circulation, February 20, 2007; 115(7): 918 - 927. [Full Text] [PDF] |
||||
![]() |
C M C van Campen, F C Visser, C C de Cock, H S Vos, O Kamp, and C A Visser Comparison of the haemodynamics of different pacing sites in patients undergoing resynchronisation treatment: need for individualisation of lead localisation Heart, December 1, 2006; 92(12): 1795 - 1800. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z I Whinnett, J E R Davies, K Willson, C H Manisty, A W Chow, R A Foale, D Wyn Davies, A D Hughes, J Mayet, and D P Francis Haemodynamic effects of changes in atrioventricular and interventricular delay in cardiac resynchronisation therapy show a consistent pattern: analysis of shape, magnitude and relative importance of atrioventricular and interventricular delay Heart, November 1, 2006; 92(11): 1628 - 1634. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Al-Hesayen and J. D. Parker Adverse effects of atrioventricular synchronous right ventricular pacing on left ventricular sympathetic activity, efficiency, and hemodynamic status Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2377 - H2379. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Stockburger, S. Fateh-Moghadam, A. Nitardy, H. Langreck, W. Haverkamp, and R. Dietz Optimization of cardiac resynchronization guided by Doppler echocardiography: haemodynamic improvement and intraindividual variability with different pacing configurations and atrioventricular delays Europace, October 1, 2006; 8(10): 881 - 886. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Knaapen, C. P. Allaart, C. C. de Cock, and J. G.F. Bronzwaer Letter by Knaapen et al Regarding Article, "Hemodynamic Effects of Long-Term Cardiac Resynchronization Therapy: Analysis by Pressure-Volume Loops" Circulation, August 29, 2006; 114(9): e371 - e371. [Full Text] [PDF] |
||||
![]() |
D. Schlosshan, D. Barker, C. Pepper, G. Williams, C. Morley, and L.-B. Tan CRT improves the exercise capacity and functional reserve of the failing heart through enhancing the cardiac flow- and pressure-generating capacity Eur J Heart Fail, August 1, 2006; 8(5): 515 - 521. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. A. Jarcho Biventricular pacing. N. Engl. J. Med., July 20, 2006; 355(3): 288 - 294. [Full Text] [PDF] |
||||
![]() |
C. Ermis and D. G. Benditt Cardiac resynchronization pacing without defibrillator capability: is this a viable option? Europace, July 1, 2006; 8(7): 499 - 501. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Steendijk, S. A. Tulner, J. J. Bax, P. V. Oemrawsingh, G. B. Bleeker, L. van Erven, H. Putter, H. F. Verwey, E. E. van der Wall, and M. J. Schalij Hemodynamic Effects of Long-Term Cardiac Resynchronization Therapy: Analysis by Pressure-Volume Loops Circulation, March 14, 2006; 113(10): 1295 - 1304. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Lindner, J. Sorensen, J. Vogt, E. Fricke, D. Baller, D. Horstkotte, and W. Burchert Cardiac Efficiency and Oxygen Consumption Measured with 11C-Acetate PET After Long-Term Cardiac Resynchronization Therapy J. Nucl. Med., March 1, 2006; 47(3): 378 - 383. [Abstract] [Full Text] [PDF] |
||||
![]() |
H. Wieneke, K. Sattler, C. von Birgelen, D. Bose, M. Haude, W. Rechenberg, S. Sack, N. Dagres, and R. Erbel Impact of intraventricular conduction delay on coronary haemodynamics: a study with intracoronary Doppler in patients with bundle branch blocks and normal coronary arteries. Europace, March 1, 2006; 8(3): 151 - 156. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. Kass Cardiac Resynchronization Therapy and Cardiac Reserve: How You Climb a Staircase May Alter Its Steepness Circulation, February 21, 2006; 113(7): 923 - 925. [Full Text] [PDF] |
||||
![]() |
M. G. St John Sutton, T. Plappert, K. E. Hilpisch, W. T. Abraham, D. L. Hayes, and E. Chinchoy Sustained Reverse Left Ventricular Structural Remodeling With Cardiac Resynchronization at One Year Is a Function of Etiology: Quantitative Doppler Echocardiographic Evidence From the Multicenter InSync Randomized Clinical Evaluation (MIRACLE) Circulation, January 17, 2006; 113(2): 266 - 272. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Flevari, G. Theodorakis, I. Paraskevaidis, F. Kolokathis, A. Kostopoulou, D. Leftheriotis, C. Kroupis, E. Livanis, and D. T. Kremastinos Coronary and peripheral blood flow changes following biventricular pacing and their relation to heart failure improvement. Europace, January 1, 2006; 8(1): 44 - 50. [Abstract] [Full Text] [PDF] |
||||
![]() |
Z. I. Whinnett, J. E.R. Davies, K. Willson, A. W. Chow, R. A. Foale, D. W. Davies, A. D. Hughes, D. P. Francis, and J. Mayet Determination of optimal atrioventricular delay for cardiac resynchronization therapy using acute non-invasive blood pressure. Europace, January 1, 2006; 8(5): 358 - 366. [Abstract] [Full Text] [PDF] |
||||
![]() |
S Ellery, L Williams, and M Frenneaux Role of resynchronisation therapy and implantable cardioverter defibrillators in heart failure Postgrad. Med. J., January 1, 2006; 82(963): 16 - 23. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. J. Bax, T. Abraham, S. S. Barold, O. A. Breithardt, J. W.H. Fung, S. Garrigue, J. Gorcsan III, D. L. Hayes, D. A. Kass, J. Knuuti, et al. Cardiac Resynchronization Therapy: Part 2--Issues During and After Device Implantation and Unresolved Questions J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2168 - 2182. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Ermis, R. Seutter, A. X. Zhu, L. C. Benditt, L. VanHeel, S. Sakaguchi, K. G. Lurie, F. Lu, and D. G. Benditt Impact of Upgrade to Cardiac Resynchronization Therapy on Ventricular Arrhythmia Frequency in Patients With Implantable Cardioverter-Defibrillators J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2258 - 2263. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. M. Dubin, J. Janousek, E. Rhee, M. J. Strieper, F. Cecchin, I. H. Law, K. M. Shannon, J. Temple, E. Rosenthal, F. J. Zimmerman, et al. Resynchronization Therapy in Pediatric and Congenital Heart Disease Patients: An International MultiCenter Study J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2277 - 2283. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. R. Leon, W. T. Abraham, S. Brozena, J. P. Daubert, W. G. Fisher, J. C. Gurley, C. S. Liang, G. Wong, and for the InSync III Clinical Study Investigators Cardiac Resynchronization With Sequential Biventricular Pacing for the Treatment of Moderate-to-Severe Heart Failure J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2298 - 2304. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. M. van Gelder, F. A. Bracke, A. Meijer, and N. H.J. Pijls The Hemodynamic Effect of Intrinsic Conduction During Left Ventricular Pacing as Compared to Biventricular Pacing J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2305 - 2310. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. M. Feldman, G. de Lissovoy, M. R. Bristow, L. A. Saxon, T. De Marco, D. A. Kass, J. Boehmer, S. Singh, D. J. Whellan, P. Carson, et al. Cost Effectiveness of Cardiac Resynchronization Therapy in the Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Trial J. Am. Coll. Cardiol., December 20, 2005; 46(12): 2311 - 2321. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Burkhoff and S. A. Ben-Haim Nonexcitatory electrical signals for enhancing ventricular contractility: rationale and initial investigations of an experimental treatment for heart failure Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2550 - H2556. [Full Text] [PDF] |
||||
![]() |
D. L. Mann and M. R. Bristow Mechanisms and Models in Heart Failure: The Biomechanical Model and Beyond Circulation, May 31, 2005; 111(21): 2837 - 2849. [Full Text] [PDF] |
||||
![]() |
R. H. Helm, C. Leclercq, O. P. Faris, C. Ozturk, E. McVeigh, A. C. Lardo, and D. A. Kass Cardiac Dyssynchrony Analysis Using Circumferential Versus Longitudinal Strain: Implications for Assessing Cardiac Resynchronization Circulation, May 31, 2005; 111(21): 2760 - 2767. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Bernheim, P. Ammann, C. Sticherling, P. Burger, B. Schaer, H. P. Brunner-La Rocca, J. Eckstein, S. Kiencke, C. Kaiser, A. Linka, et al. Right Atrial Pacing Impairs Cardiac Function During Resynchronization Therapy: Acute Effects of DDD Pacing Compared to VDD Pacing J. Am. Coll. Cardiol., May 3, 2005; 45(9): 1482 - 1487. [Abstract] [Full Text] [PDF] |
||||
![]() |
A Y Patwala and D J Wright Device based treatment of heart failure Postgrad. Med. J., May 1, 2005; 81(955): 286 - 291. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. A. Strickberger, J. Conti, E. G. Daoud, E. Havranek, M. R. Mehra, I. L. Pina, J. Young, and Endorsed by the American College of Cardiology Fou Patient Selection for Cardiac Resynchronization Therapy: From the Council on Clinical Cardiology Subcommittee on Electrocardiography and Arrhythmias and the Quality of Care and Outcomes Research Interdisciplinary Working Group, in Collaboration With the Heart Rhythm Society Circulation, April 26, 2005; 111(16): 2146 - 2150. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Lindner, J. Vogt, D. Baller, A. Kammeier, P. Wielepp, J. Holzinger, B. Lamp, D. Horstkotte, and W. Burchert Global and regional myocardial oxygen consumption and blood flow in severe cardiomyopathy with left bundle branch block Eur J Heart Fail, March 2, 2005; 7(2): 225 - 230. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Y. Vanagt, X. A. Verbeek, T. Delhaas, M. Gewillig, L. Mertens, P. Wouters, B. Meyns, W. J. Daenen, and F. W. Prinzen Acute Hemodynamic Benefit of Left Ventricular Apex Pacing in Children Ann. Thorac. Surg., March 1, 2005; 79(3): 932 - 936. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. Lindner, J. Vogt, A. Kammeier, P. Wielepp, J. Holzinger, D. Baller, B. Lamp, B. Hansky, R. Korfer, D. Horstkotte, et al. Effect of cardiac resynchronization therapy on global and regional oxygen consumption and myocardial blood flow in patients with non-ischaemic and ischaemic cardiomyopathy Eur. Heart J., January 1, 2005; 26(1): 70 - 76. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. Heinke, R. Surber, H. Kühnert, G. Dannberg, G. Schwarz, and H. R. Figulla Transoesophageal left ventricular pacing in heart failure patients with permanent right ventricular pacing Europace, January 1, 2005; 7(6): 617 - 620. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-B. Thambo, P. Bordachar, S. Garrigue, S. Lafitte, P. Sanders, S. Reuter, R. Girardot, D. Crepin, P. Reant, R. Roudaut, et al. Detrimental Ventricular Remodeling in Patients With Congenital Complete Heart Block and Chronic Right Ventricular Apical Pacing Circulation, December 21, 2004; 110(25): 3766 - 3772. [Abstract] [Full Text] [PDF] |
||||
![]() |
P Schuster, S Faerestrand, and O J Ohm Reverse remodelling of systolic left ventricular contraction pattern by long term cardiac resynchronisation therapy: colour Doppler shows resynchronisation Heart, December 1, 2004; 90(12): 1411 - 1416. [Abstract] [Full Text] [PDF] |
||||
![]() |
R E Lane, A W C Chow, D Chin, and J Mayet Selection and optimisation of biventricular pacing: the role of echocardiography Heart, December 1, 2004; 90(suppl_6): vi10 - vi16. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Janousek, V. Tomek, V. Chaloupecky, O. Reich, R. A. Gebauer, J. Kautzner, and B. Hucin Cardiac resynchronization therapy: A novel adjunct to the treatment and prevention of systemic right ventricular failure J. Am. Coll. Cardiol., November 2, 2004; 44(9): 1927 - 1931. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. A. Bacha, F. J. Zimmerman, V. Mor-Avi, L. Weinert, J. P. Starr, L. Sugeng, and R. M. Lang Ventricular Resynchronization by Multisite Pacing Improves Myocardial Performance in the Postoperative Single-Ventricle Patient Ann. Thorac. Surg., November 1, 2004; 78(5): 1678 - 1683. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Knaapen, L. M.C. van Campen, C. C. de Cock, M. J.W. Gotte, C. A. Visser, A. A. Lammertsma, and F. C. Visser Effects of Cardiac Resynchronization Therapy on Myocardial Perfusion Reserve Circulation, August 10, 2004; 110(6): 646 - 651. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. Faber, B. Lamp, J. Vogt, and D. Horstkotte Tissue Doppler imaging in patients with congestive heart failure and conduction disorders Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D10 - D15. [Abstract] [Full Text] [PDF] |
||||
![]() |
O. A. Breithardt, L. Herbots, J. D'Hooge, P. Claus, B. Bijnens, C. Stellbrink, A. Franke, and G. R. Sutherland Strain rate imaging in CRT candidates Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D16 - D24. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Vogt, J. Heintze, B. Lamp, B. Hansky, and D. Horstkotte Standard haemodynamic measurements Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D29 - D34. [Abstract] [Full Text] [PDF] |
||||
![]() |
P. Steendijk, S. A.F. Tulner, M. Wiemer, R. A. Bleasdale, J. J. Bax, E. E. van der Wall, J. Vogt, and M. J. Schalij Pressure-volume measurements by conductance catheter during cardiac resynchronization therapy Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D35 - D42. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. P Boehmer CRT only or CRT plus ICD? Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D83 - D87. [Abstract] [Full Text] [PDF] |
||||
![]() |
D Baller, J Vogt, O Lindner, B Lamp, J Holzinger, A Kammeier, P Wielepp, W Burchert, and D Horstkotte Myocardial oxygen consumption and perfusion before and after cardiac resynchronization therapy: experimental observations and clinical implications Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D91 - D97. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. Gras, J. P. Cebron, P. Brunel, B. Leurent, and Y. Banus The selection of patients for cardiac resynchronization therapy Eur. Heart J. Suppl., August 1, 2004; 6(suppl_D): D98 - D100. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. G. Rabkin, L. J. Curtis, S. E. Cabreriza, A. D. Weinberg, and H. M. Spotnitz Load dependence of cardiac output in biventricular pacing: Right ventricular volume overload in pigs J. Thorac. Cardiovasc. Surg., July 1, 2004; 128(1): 98 - 102. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. J. Magner and D. Royston Heart failure Br. J. Anaesth., July 1, 2004; 93(1): 74 - 85. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. A. Nikolaidis, D. Trumble, T. Hentosz, A. Doverspike, R. Huerbin, M. A. Mathier, Y.-T. Shen, and R. P. Shannon Catecholamines restore myocardial contractility in dilated cardiomyopathy at the expense of increased coronary blood flow and myocardial oxygen consumption (MvO2 cost of catecholamines in heart failure) Eur J Heart Fail, June 1, 2004; 6(4): 409 - 419. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. R. Bristow, L. A. Saxon, J. Boehmer, S. Krueger, D. A. Kass, T. De Marco, P. Carson, L. DiCarlo, D. DeMets, B. G. White, et al. Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure N. Engl. J. Med., May 20, 2004; 350(21): 2140 - 2150. [Abstract] [Full Text] [PDF] |
||||
![]() |
P D. Bella and C Carbucicchio Non-contact left ventricular endocardial mapping for cardiac resynchronisation therapy: a "slow conduction" towards the fast solution Heart, May 1, 2004; 90(5): 483 - 484. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. J. M. Zwanenburg, M. J. W. Gotte, J. P. A. Kuijer, R. M. Heethaar, A. C. van Rossum, and J. T. Marcus Timing of cardiac contraction in humans mapped by high-temporal-resolution MRI tagging: early onset and late peak of shortening in lateral wall Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1872 - H1880. [Abstract] [Full Text] [PDF] |
||||
![]() |
J.-J. Blanc, V. Bertault-Valls, M. Fatemi, M. Gilard, P.-Y. Pennec, and Y. Etienne Midterm Benefits of Left Univentricular Pacing in Patients With Congestive Heart Failure Circulation, April 13, 2004; 109(14): 1741 - 1744. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. Sundell, E. Engblom, J. Koistinen, A. Ylitalo, A. Naum, K. Q. Stolen, R. Kalliokoski, S. G. Nekolla, K. E. J. Airaksinen, J. J. Bax, et al. The effects of cardiac resynchronization therapy on left ventricular function, myocardial energetics, and metabolic reserve in patients with dilated cardiomyopathy and heart failure J. Am. Coll. Cardiol., March 17, 2004; 43(6): 1027 - 1033. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. Leclercq and J. M. Hare Ventricular Resynchronization: Current State of the Art Circulation, January 27, 2004; 109(3): 296 - 299. [Full Text] [PDF] |
||||
![]() |
H. Bader, S. Garrigue, S. Lafitte, S. Reuter, P. Jais, M. Haissaguerre, J. Bonnet, J. Clementy, and R. Roudaut Intra-left ventricular electromechanical asynchrony: A new independent predictor of severe cardiac events in heart failure patients J. Am. Coll. Cardiol., January 21, 2004; 43(2): 248 - 256. [Abstract] [Full Text] [PDF] |
||||
![]() |
V.ér. Valls-Bertault, M. Fatemi, M. Gilard, P. Y. Pennec, Y. Etienne, and J.-J. Blanc Assessment of upgrading to biventricular pacing in patients with right ventricular pacing and congestive heart failure after atrioventricular junctional ablation for chronic atrial fibrillation Europace, January 1, 2004; 6(5): 438 - 443. [Abstract] [Full Text] [PDF] |
||||
![]() |
P D Lambiase, A Rinaldi, J Hauck, M Mobb, D Elliott, S Mohammad, J S Gill, and C A Bucknall Non-contact left ventricular endocardial mapping in cardiac resynchronisation therapy Heart, January 1, 2004; 90(1): 44 - 51. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. Auricchio, C. Stellbrink, C. Butter, S. Sack, J. Vogt, A. R. Misier, D. Bocker, M. Block, J. H. Kirkels, Pacing Therapies in Congestive Heart Failure (PATH, et al. Clinical efficacy of cardiac resynchronization therapy using left ventricular pacing in heart failure patients stratified by severity of ventricular conduction delay J. Am. Coll. Cardiol., December 17, 2003; 42(12): 2109 - 2116. [Abstract] [Full Text] [PDF] |
||||
![]() |
D. A. Kass Predicting cardiac resynchronization response by qrs duration: The long and short of it J. Am. Coll. Cardiol., December 17, 2003; 42(12): 2125 - 2127. [Full Text] [PDF] |
||||
![]() |
Y. Yu, A. Kramer, J. Spinelli, J. Ding, W. Hoersch, and A. Auricchio Biventricular mechanical asynchrony predicts hemodynamic effect of uni- and biventricular pacing Am J Physiol Heart Circ Physiol, December 1, 2003; 285(6): H2788 - H2796. [Abstract] [Full Text] [PDF] |
||||
![]() |
L. A. Saxon and K. A. Ellenbogen Resynchronization Therapy for the Treatment of Heart Failure Circulation, September 2, 2003; 108(9): 1044 - 1048. [Full Text] [PDF] |
||||
![]() |
O.-A. Breithardt, C. Stellbrink, L. Herbots, P. Claus, A. M. Sinha, B. Bijnens, P. Hanrath, and G. R. Sutherland Cardiac resynchronization therapy can reverse abnormal myocardial strain distribution in patients with heart failure and left bundle branch block J. Am. Coll. Cardiol., August 6, 2003; 42(3): 486 - 494. [Abstract] [Full Text] [PDF] |
||||
![]() |
X. A. A. M. Verbeek, K. Vernooy, M. Peschar, R. N. M. Cornelussen, and F. W. Prinzen Intra-ventricular resynchronization for optimal left ventricular function during pacing in experimental left bundle branch block J. Am. Coll. Cardiol., August 6, 2003; 42(3): 558 - 567. [Abstract] [Full Text] [PDF] |
||||
![]() |
P Schuster, S Faerestrand, and O-J Ohm Colour tissue velocity imaging can show resynchronisation of longitudinal left ventricular contraction pattern by biventricular pacing in patients with severe heart failure Heart, August 1, 2003; 89(8): 859 - 864. [Abstract] [Full Text] [PDF] |
||||
|
Circulation Home | Subscriptions | Archives | Feedback | Authors | Help | AHA Journals Home | Search Copyright © 2000 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. |