(Circulation. 2000;102:2169.)
© 2000 American Heart Association, Inc.
Brief Rapid Communications |
Olive Phenol Hydroxytyrosol Prevents Passive Smoking–Induced Oxidative Stress
From the University of Milan, Institute of Pharmacological Sciences, Milan, Italy.
Correspondence to Francesco Visioli, PhD, Institute of Pharmacological Sciences, Via Balzaretti 9, 20133 Milan, Italy. E-mail francesco.visioli{at}unimi.it
Background—Oxidative stress is
involved in the onset of several degenerative disorders, and
epidemiological studies indicate that a high intake of dietary
antioxidants, as in the case of the Mediterranean basin, is protective.
Olive mill waste waters (OMWWs) are a byproduct of olive oil
production rich in phenolic antioxidants, such as
hydroxytyrosol. We tested the effects of a low dose of an OMWW extract
in a model of sidestream smoke–induced oxidative stress in rats by
evaluating the urinary excretion of 8-iso-prostaglandin
(PG) F2
(iPF2-III).
Methods and Results—An OMWW extract (5 mg/kg, providing 414
µg/kg of hydroxytyrosol) was administered to rats daily for 4 days,
during which time the animals were exposed to sidestream smoke for 20
minutes once a day. Daily urines were collected, and the urinary
excretion of 8-iso-PGF2 was evaluated as an index of
oxidative stress–induced in vivo lipid peroxidation. The exposure of
rats to passive smoking increased the urinary excretion of
8-iso-PGF2 by 44±4.2% at 48 hours and by 55±10% at
96 hours. Treatment with the OMWW extract was able to completely
prevent the increase at 48 hours and resulted in lower increments
(34±18% versus 55±10%) of 8-iso-PGF2 excretion at
96 hours.
Conclusions—A low dose of hydroxytyrosol, administered through OMWW, reduces the consequences of sidestream smoke–induced oxidative stress in rats.
Key Words: hydroxytyrosol • isoprostanes • atherosclerosis • smoking • lipids
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