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(Circulation. 2000;102:1611.)
© 2000 American Heart Association, Inc.
Clinical Investigation and Reports |
Elevated Troponin I Level on Admission Is Associated With Adverse Outcome of Primary Angioplasty in Acute Myocardial Infarction
From the Division of Cardiology, Cedars-Sinai Medical Center/UCLA School of Medicine, Los Angeles, Calif.
Correspondence to Bojan Cercek, Division of Cardiology, Cedars-Sinai Medical Center, Room 5314, 8700 Beverly Blvd, PO Box 48750, Los Angeles, CA 90048-1865. E-mail cercek{at}cshs.org
Background—In patients with acute myocardial infarction (AMI) undergoing thrombolytic therapy, an elevated troponin level on admission is associated with a lower reperfusion rate and a complicated clinical course. Whether an elevated troponin level on admission similarly predicts an adverse outcome in patients undergoing primary angioplasty is currently unknown and was investigated in the present study.
Methods and Results—Cardiac troponin I (cTnI) was determined on
admission in 110 consecutive patients with AMI associated with
ST-segment elevation or left bundle branch block who underwent primary
angioplasty. Fifty-four patients (49%) had an elevated cTnI (
0.4
ng/mL) on admission. In patients with elevated cTnI, primary
angioplasty was less likely to achieve TIMI 3 flow (as classified by
the Thrombolysis in Myocardial Infarction trial) in
univariate (76% versus 96%, P=0.03) or in
multivariate (odds ratio 0.1, 95% CI 0.02 to 0.54)
analysis. Patients with elevated cTnI were more likely to
develop congestive heart failure (23% versus 9%,
P<0.05) and death, heart failure, or shock (30% versus
9%, P=0.006). Elevated cTnI remained a significant
predictor of the composite end point after controlling for other
clinical data that were available early in the course, including time
to presentation and angiographic results (relative risk
5.2, 95% CI 1.03 to 26.3). During a follow-up of 426±50 days,
elevated admission cTnI was a predictor of cardiac mortality (11%
versus 0%, P=0.012), adverse cardiac events (cardiac
mortality or nonfatal reinfarction; 19% versus 5.4%,
P=0.04), and adverse cardiac events plus target vessel
revascularization (32% versus 14%,
P=0.054).
Conclusions—In patients with ST-segment elevation AMI, an elevated cTnI on admission is associated with an increased risk of primary angioplasty failure and a more complicated clinical course.
Key Words: angioplasty • myocardial infarction • reperfusion • proteins
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