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(Circulation. 2000;101:553.)
© 2000 American Heart Association, Inc.

Basic Science Reports

Antihypertensive Effect of 0.1-Hz Blood Pressure Oscillations to the Kidney

Benno Nafz, MD; Jens Stegemann; Morton H. Bestle, MD; Nadja Richter, PhD; Erdmann Seeliger, MD; Ingolf Schimke, PhD; H. Wolfgang Reinhardt, MD; Pontus B. Persson, MD

From the Institut für Physiologie (B.N., J.S., E.S., H.W.R., P.B.P.) and the Institut für klinische Chemie (N.R., I.S.) der Humboldt Universität Berlin, Berlin, Germany, and the Department of Medical Physiology, University of Copenhagen Panum Institute, Copenhagen, Denmark (M.H.B.).

Correspondence to Dr Benno Nafz, Physiologisches Institut der Charité, Humboldt Universität Berlin, Tucholskystraße 2, 10117 Berlin, Germany. E-mail b.nafz{at}gmx.de

Background—Physiological blood pressure (BP) fluctuations with frequencies >0.1 Hz can override renal blood flow autoregulation. The influence of such immediate changes in renal perfusion pressure (RPP) on daily BP regulation, eg, via shear stress–stimulated liberation of renal endothelial NO, however, is unknown. Thus, we studied the effects of such RPP oscillations on renal function and on systemic BP during the onset of renal hypertension.

Methods and Results—Seven beagles (randomly assigned to each of the following protocols) were chronically instrumented for the measurement of systemic BP, RPP, and renal excretory function. An inflatable cuff was used to reduce and to oscillate RPP over 24 hours in the freely moving dog. Reducing RPP to 87±2 mm Hg diminished excretion of sodium and water and doubled plasma renin activity (PRA, n=7, P<0.01) but had no significant effect on urinary nitrate excretion (n=6), a marker of NO generation. Superimposing 0.1-Hz oscillations (±10 mm Hg) onto the reduced RPP blunted hypertension, returned fluid excretion almost to control levels, and doubled renal sodium elimination. Nitrate excretion peaked at 8 hours, only to return to control values shortly thereafter. PRA, conversely, was significantly reduced during the last third of the experimental protocols.

Conclusions—BP fluctuations transiently stimulate NO liberation and induce a reduction in PRA, which enhances 24-hour sodium and water excretion and markedly attenuates the acute development of renovascular hypertension.

Key Words: hemodynamics • hypertension • kidney • Fourier analysis • renin

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