This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Poulsen, S. H. Articles by Egstrup, K. Search for Related Content PubMed PubMed Citation Articles by Poulsen, S. H. Articles by Egstrup, K. Related Collections Acute myocardial infarction

(Circulation. 2000;101:1527.)
© 2000 American Heart Association, Inc.

Clinical Investigation and Reports

Relationship Between Serum Amino-Terminal Propeptide of Type III Procollagen and Changes of Left Ventricular Function After Acute Myocardial Infarction

Steen H. Poulsen, MD, PhD; Nis B. Høst, MD, PhD; Svend E. Jensen, MD; Kenneth Egstrup, MD, DMSci, FESC

From the Department of Internal Medicine, Division of Cardiology, Haderslev Hospital, Haderslev, and the Laboratory of Rheumatology, Hvidovre Hospital (N.B.H.), Copenhagen, Denmark.

Correspondence to Steen Hvitfeldt Poulsen, MD, PhD, Birkhøjen 53, 8382 Hinnerup, Denmark. E-mail steen.hvitfeldt{at}dadlnet.dk

Background—The amino-terminal propeptide of type III procollagen (PIIINP) is a marker of type III collagen synthesis, which has previously been shown to correlate with infarct size in nonthrombolyzed myocardial infarction (MI) and to provide prognostic information after MI.

Methods and Results—The relationship between PIIINP and changes of left ventricular (LV) function was studied in 47 consecutive patients with first acute MI and 16 control subjects. Serum PIIINP analysis was measured daily during hospitalization and on days 90, 180, and 360. LV function was assessed by echocardiography on days 1, 5, 90, and 360. Patients with MI were stratified according to their serum PIIINP value at day 4 (group A, 5.0 µg/L; group B, >5.0 µg/L). On arrival, LV function and size were comparable between groups A (n=31) and B (n=16). LV ejection fraction, initially depressed (day 1: group A, 47±7% versus group B, 47±8%; P=NS), increased significantly in group A (day 360: 54±8%, P<0.001) but was unchanged in group B (day 360: 43±8%, P=NS). LV volumes increased significantly in group B (P<0.05) but not in group A. Furthermore, patients in group B developed signs of restrictive LV diastolic filling. Multivariate regression analysis identified PIIINP >5.0 µg/L and deceleration 140 ms as independent predictors of cardiac death or complicating heart failure during follow-up.

Conclusions—PIIINP assessed in the subacute phase of MI relates to long-term changes of LV function and provides clinical prognostic information.

Key Words: myocardial infarction • remodeling • collagen • systole • diastole

This article has been cited by other articles:

				H. Su, F. G. Spinale, L. W. Dobrucki, J. Song, J. Hua, S. Sweterlitsch, D. P. Dione, P. Cavaliere, C. Chow, B. N. Bourke, et al. Noninvasive Targeted Imaging of Matrix Metalloproteinase Activation in a Murine Model of Postinfarction Remodeling Circulation, November 15, 2005; 112(20): 3157 - 3167. [Abstract] [Full Text] [PDF]

				L. Anderson Candidate-based proteomics in the search for biomarkers of cardiovascular disease J. Physiol., February 15, 2005; 563(1): 23 - 60. [Abstract] [Full Text] [PDF]

				A Rossi, M Cicoira, G Golia, L Zanolla, L Franceschini, P Marino, M Graziani, and P Zardini Amino-terminal propeptide of type III procollagen is associated with restrictive mitral filling pattern in patients with dilated cardiomyopathy: a possible link between diastolic dysfunction and prognosis Heart, June 1, 2004; 90(6): 650 - 654. [Abstract] [Full Text] [PDF]

				M. Hayashi, T. Tsutamoto, A. Wada, T. Tsutsui, C. Ishii, K. Ohno, M. Fujii, A. Taniguchi, T. Hamatani, Y. Nozato, et al. Immediate Administration of Mineralocorticoid Receptor Antagonist Spironolactone Prevents Post-Infarct Left Ventricular Remodeling Associated With Suppression of a Marker of Myocardial Collagen Synthesis in Patients With First Anterior Acute Myocardial Infarction Circulation, May 27, 2003; 107(20): 2559 - 2565. [Abstract] [Full Text] [PDF]

				M. Hayashi, T. Tsutamoto, A. Wada, K. Maeda, N. Mabuchi, T. Tsutsui, T. Matsui, M. Fujii, T. Matsumoto, T. Yamamoto, et al. Relationship between transcardiac extraction of aldosterone and left ventricular remodeling in patients with first acute myocardial infarction: extracting aldosterone through the heart promotes ventricular remodeling after acute myocardial infarction J. Am. Coll. Cardiol., November 1, 2001; 38(5): 1375 - 1382. [Abstract] [Full Text] [PDF]

				F. Zannad, B. Dousset, and F. Alla Treatment of Congestive Heart Failure: Interfering the Aldosterone-Cardiac Extracellular Matrix Relationship Hypertension, November 1, 2001; 38(5): 1227 - 1232. [Abstract] [Full Text] [PDF]

				S H Poulsen, S E Jensen, J E Moller, and K Egstrup Prognostic value of left ventricular diastolic function and association with heart rate variability after a first acute myocardial infarction Heart, October 1, 2001; 86(4): 376 - 380. [Abstract] [Full Text] [PDF]