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(Circulation. 1999;100:1623-1629.)
© 1999 American Heart Association, Inc.

Clinical Investigation and Reports

Preserved Endothelium-Dependent Vasodilation in Coronary Segments Previously Treated With Balloon Angioplasty and Intracoronary Irradiation

Manel Sabaté, MD; I. Patrick Kay, MBChB; Willem J. van der Giessen, MD, PhD; Angel Cequier, MD, PhD; Jurgen M. R. Ligthart, BSc; Joan Antoni Gómez-Hospital, MD; Stéphane G. Carlier, MD; Veronique L. M. A. Coen, MD; Johannes P. A. Marijnissen, PhD; Alexander J. Wardeh, MD; Peter C. Levendag, MD, PhD; Patrick W. Serruys, MD, PhD

From the Thoraxcenter, Heartcenter, Rotterdam, Dijkzigt Academisch Ziekenhuis Rotterdam, The Netherlands (M.S., I.P.K., W.J.v.d.G., J.M.R.L., S.G.C., A.J.W., P.W.S.); Daniel den Hoed Cancer Center, Rotterdam, The Netherlands (V.L.M.A.C., J.P.A.M., P.C.L.); and Hospital de Bellvitge, Universitat de Barcelona, Barcelona, Spain (A.C., J.A.G.-H.).

Correspondence to P.W. Serruys, MD, PhD, Professor of Interventional Cardiology, Head of Department of Interventional Cardiology, Bd 412, Heartcenter, Academisch Ziekenhuis Rotterdam, Erasmus University, PO Box 1738, Dr Molewaterplein 40, 3000 DR Rotterdam, Netherlands. E-mail serruys{at}card.azr.nl

Background—Abnormal endothelium-dependent coronary vasomotion has been reported after balloon angioplasty (BA), as well as after intracoronary radiation. However, the long-term effect on coronary vasomotion is not known. The aim of this study was to evaluate the long-term vasomotion of coronary segments treated with BA and brachytherapy.

Methods and Results—Patients with single de novo lesions treated either with BA followed by intracoronary ß-irradiation (according to the Beta Energy Restenosis Trial-1.5) or with BA alone were eligible. Of these groups, those patients in stable condition who returned for 6-month angiographic follow-up formed the study population (n=19, irradiated group and n=11, control group). Endothelium-dependent coronary vasomotion was assessed by selective infusion of serial doses of acetylcholine (ACh) proximally to the treated area. Mean luminal diameter was calculated by quantitative coronary angiography both in the treated area and in distal segments. Endothelial dysfunction was defined as a vasoconstriction after the maximal dose of ACh (10^-6 mol/L). Seventeen irradiated segments (89.5%) demonstrated normal endothelial function. In contrast, 10 distal nonirradiated segments (53%) and 5 control segments (45%) demonstrated endothelium-dependent vasoconstriction (-19±17% and -9.0±5%, respectively). Mean percentage of change in mean luminal diameter after ACh was significantly higher in irradiated segments (P=0.01).

Conclusions—Endothelium-dependent vasomotion of coronary segments treated with BA followed by ß-radiation is restored in the majority of stable patients at 6-month follow-up. This functional response appeared to be better than those documented both in the distal segments and in segments treated with BA alone.

Key Words: balloon • angioplasty • radioisotopes • endothelium • acetylcholine

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