This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Hilgers, K. F. Articles by Schmieder, R. E. Search for Related Content PubMed PubMed Citation Articles by Hilgers, K. F. Articles by Schmieder, R. E. Related Collections ACE/Angiotension receptors Other hypertension Genetics of cardiovascular disease

(Circulation. 1999;100:1394-1399.)
© 1999 American Heart Association, Inc.

Clinical Investigation and Reports

1166 A/C Polymorphism of the Angiotensin II Type 1 Receptor Gene and the Response to Short-Term Infusion of Angiotensin II

Karl F. Hilgers, MD; Matthias R. W. Langenfeld, MD; Markus Schlaich, MD; Roland Veelken, MD; Roland E. Schmieder, MD

From the Department of Medicine/Nephrology, University of Erlangen-Nürnberg, Germany.

Correspondence to Prof Dr Roland E. Schmieder, Medizinische Klinik IV der Universität Erlangen-Nürnberg, Breslauer Strasse 201, D-90471 Nürnberg, Germany.

Background—Previous studies reported an association of the 1166 A/C polymorphism of the angiotensin II (Ang II) type 1 receptor gene with high blood pressure and cardiovascular disease. We tested the hypothesis that this polymorphism affects the blood-pressure, renal hemodynamic, and aldosterone response to infused Ang II.

Methods and Results—Young, male, white volunteers (n=116) with normal (n=65) or mildly elevated (n=51) blood pressure on a high salt intake were genotyped for the 1166 A/C polymorphism. Two doses of Ang II (0.5 and 3 ng · kg^-1 · min^-1 over 30 minutes each) increased blood pressure, plasma aldosterone, glomerular filtration rate, and filtration fraction and decreased renal blood flow. The blood-pressure, renal hemodynamic, and aldosterone responses were not significantly different between subjects homozygous for the A allele (n=56) and heterozygous subjects (n=47) or subjects homozygous for the C allele (n=13). Comparison of A allele homozygotes with all C allele carriers pooled (n=60) or restriction of the analysis to normotensive volunteers also revealed no significant differences between genotypes.

Conclusions—The 1166 C variant of the Ang II type 1 receptor does not lead to a greater blood-pressure, aldosterone, or renal vascular response to infused Ang II in young, male, white subjects. We conclude that the 1166 A/C polymorphism does not have a major effect on these actions of Ang II.

Key Words: angiotensin • genes • kidney • blood pressure

This article has been cited by other articles:

				D. N. Muller, B. Klanke, S. Feldt, N. Cordasic, A. Hartner, R. E. Schmieder, F. C. Luft, and K. F. Hilgers (Pro)Renin Receptor Peptide Inhibitor "Handle-Region" Peptide Does Not Affect Hypertensive Nephrosclerosis in Goldblatt Rats Hypertension, March 1, 2008; 51(3): 676 - 681. [Abstract] [Full Text] [PDF]

				J. Jacobi, R. Maas, N. Cordasic, K. Koch, R. E. Schmieder, R. H. Boger, and K. F. Hilgers Role of asymmetric dimethylarginine for angiotensin II-induced target organ damage in mice Am J Physiol Heart Circ Physiol, February 1, 2008; 294(2): H1058 - H1066. [Abstract] [Full Text] [PDF]

				M. E. A. Spaanderman, T. H. A. Ekhart, P. W. de Leeuw, and L. L. H. Peeters Angiotensin II Sensitivity in Nonpregnant Formerly Preeclamptic Women and Halthy Parous Contorls Reproductive Sciences, September 1, 2004; 11(6): 416 - 422. [Abstract] [PDF]

				C.-T. Tsai, L.-P. Lai, J.-L. Lin, F.-T. Chiang, J.-J. Hwang, M. D. Ritchie, J. H. Moore, K.-L. Hsu, C.-D. Tseng, C.-S. Liau, et al. Renin-Angiotensin System Gene Polymorphisms and Atrial Fibrillation Circulation, April 6, 2004; 109(13): 1640 - 1646. [Abstract] [Full Text] [PDF]

				C.-T. Tsai, D. Fallin, F.-T. Chiang, J.-J. Hwang, L.-P. Lai, K.-L. Hsu, C.-D. Tseng, C.-S. Liau, and Y.-Z. Tseng Angiotensinogen Gene Haplotype and Hypertension: Interaction With ACE Gene I Allele Hypertension, January 1, 2003; 41(1): 9 - 15. [Abstract] [Full Text] [PDF]

				K. F. Hilgers, C. Delles, R. Veelken, and R. E. Schmieder Angiotensinogen Gene Core Promoter Variants and Non-Modulating Hypertension Hypertension, December 1, 2001; 38(6): 1250 - 1254. [Abstract] [Full Text] [PDF]

				R. E. Schmieder, J. Erdmann, C. Delles, J. Jacobi, E. Fleck, K. Hilgers, and V. Regitz-Zagrosek Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans J. Am. Coll. Cardiol., January 1, 2001; 37(1): 175 - 182. [Abstract] [Full Text] [PDF]

				W. Spiering, A. A. Kroon, M. M. J. J. Fuss-Lejeune, M. J. A. P. Daemen, and P. W. de Leeuw Angiotensin II Sensitivity Is Associated With the Angiotensin II Type 1 Receptor A1166C Polymorphism in Essential Hypertensives on a High Sodium Diet Hypertension, September 1, 2000; 36(3): 411 - 416. [Abstract] [Full Text] [PDF]