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Circulation. 1999;100:14-20

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(Circulation. 1999;100:14-20.)
© 1999 American Heart Association, Inc.

Clinical Investigation and Reports

Relationship Between Delay in Performing Direct Coronary Angioplasty and Early Clinical Outcome in Patients With Acute Myocardial Infarction

Results From the Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes (GUSTO-IIb) Trial

Peter B. Berger, MD; Stephen G. Ellis, MD; David R. Holmes, Jr, MD; Christopher B. Granger, MD; Douglas A. Criger, MPH; Amadeo Betriu, MD; Eric J. Topol, MD; Robert M. Califf, MD; for the GUSTO-II Investigators

From the Division of Cardiovascular Diseases, Mayo Clinic (P.B.B., D.R.H.), Rochester, Minn; the Department of Cardiology, Cleveland Clinic (S.G.E., E.J.T.), Cleveland, Ohio; the Division of Cardiology, Duke University (C.B.G., D.A.C., R.M.C.), Durham, NC; and Hospital Clinic 1, Provincial de Barcelona (A.B.), Barcelona, Spain.

Correspondence to Peter B. Berger, MD, Division of Cardiovascular Diseases, Mayo Clinic, 200 First St SW, Rochester, MN 55905. E-mail berger.peter{at}mayo.edu

Background—Time to treatment with thrombolytic therapy is a critical determinant of mortality in acute myocardial infarction. Little is known about the relationship between the time to treatment with direct coronary angioplasty and clinical outcome. The objectives of this study were to determine both the time required to perform direct coronary angioplasty in the Global Use of Strategies to Open Occluded Arteries in Acute Coronary Syndromes (GUSTO-IIb) trial and its relationship to clinical outcome.

Methods and Results—Patients randomized to direct coronary angioplasty (n=565) were divided into groups based on the time between study enrollment and first balloon inflation. Patients randomized to angioplasty who did not undergo the procedure were also analyzed. The median time from study enrollment to first balloon inflation was 76 minutes; 19% of patients assigned to angioplasty did not undergo an angioplasty procedure. The 30-day mortality rate of patients who underwent balloon inflation <=60 minutes after study enrollment was 1.0%; 61 to 75 minutes after enrollment, 3.7%; 76 to 90 minutes after enrollment, 4.0%; and >=91 minutes after enrollment, 6.4%. The mortality rate of patients assigned to angioplasty who never underwent the procedure was 14.1% (P=0.001). Logistic regression analysis revealed that the time from enrollment to first balloon inflation was a significant predictor of mortality within 30 days; after adjustment for differences in baseline characteristics, the odds of death increased 1.6 times (P=0.008) for a movement from each time interval to the next.

Conclusions—The time to treatment with direct PTCA, as with thrombolytic therapy, is a critical determinant of mortality.


Key Words: reperfusion • myocardial infarction • angioplasty • mortality • survival




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