Published online before print October 21, 2002, doi: 10.1161/01.CIR.0000040584.91836.0D
(Circulation. 2002;106:2530.)
© 2002 American Heart Association, Inc.
Brief Rapid Communications |
Effect of Diet and Exercise Intervention on Blood Pressure, Insulin, Oxidative Stress, and Nitric Oxide Availability
From the Department of Physiological Science, University of California, Los Angeles (C.K.R., R.J.B.), and the Division of Nephrology and Hypertension, Department of Medicine, University of California, Irvine (C.K.R., N.D.V.).
Correspondence to R. James Barnard, Department of Physiological Science, UCLA, P.O. 951527, Los Angeles, CA 90095-1527. E-mail jbarnard{at}physci.ucla.edu
Background— Diet and exercise can affect blood pressure and atherosclerotic risk.
Methods and Results— The present study was designed to examine the effects of a short-term, rigorous diet and exercise intervention on blood pressure, hyperinsulinemia, and nitric oxide (NO) availability. Men (n=11) were placed on a low-fat, high-fiber diet combined with daily exercise for 45 to 60 minutes for 3 weeks. Pre- and post fasting blood was drawn for serum lipid, insulin, 8-isoprostaglandin F2
(8-iso-PGF2), and glucose measurements. Anthropometric parameters, blood pressure (BP), and 24-hour urinary NO metabolite excretion (NOX), a marker of NO bioavailability, were measured. Systolic (P<0.01) and diastolic BP (P<0.01) and 8-iso-PGF2 decreased (P<0.05), whereas urinary NOX increased (P<0.05). There was a significant reduction in fasting insulin (P<0.01) and a significant correlation between the decrease in serum insulin and the increase in urinary NOX (r2=0.68, P<0.05). All fasting lipids decreased significantly, and the total cholesterol to high-density lipoprotein cholesterol ratio improved. Although body weight and body mass index (P<0.01) decreased, obesity was still present and there were no correlations between the change in body mass index and the change in insulin, BP, or urinary NOX.
Conclusions— This intervention resulted in dramatic improvements in BP, oxidative stress, NO availability, and the metabolic profile within 3 weeks, mitigating the risk for atherosclerosis progression and its clinical sequelae.
Key Words: hypertension • free radicals • oxygen • insulin
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